Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Lekha, Sleno"'
Publikováno v:
ACS Omega, Vol 8, Iss 34, Pp 31168-31177 (2023)
Externí odkaz:
https://doaj.org/article/cea7d4eed2a449c1a8f05b0b9a22a1e1
Autor:
Farzaneh Tamnanloo, Rafael Ochoa-Sanchez, Mariana M. Oliveira, Carina Lima, Maggy Lépine, Karine Dubois, Cristina Bosoi, Mélanie Tremblay, Lekha Sleno, Christopher F. Rose
Publikováno v:
JHEP Reports, Vol 5, Iss 12, Pp 100904- (2023)
Background & Aims: Hepatic encephalopathy (HE) is defined as a reversible syndrome and therefore should resolve following liver transplantation (LT). However, neurological complications have been reported in up to 47% of LT recipients, which have bee
Externí odkaz:
https://doaj.org/article/9f380f9bd62344ed8542861c498b393c
Autor:
Makan Golizeh, John Nam, Eric Chatelain, Yves Jackson, Leanne B. Ohlund, Asieh Rasoolizadeh, Fabio Vasquez Camargo, Louiza Mahrouche, Alexandra Furtos, Lekha Sleno, Momar Ndao
Publikováno v:
Heliyon, Vol 8, Iss 12, Pp e12380- (2022)
The causative agent of Chagas disease (CD), Trypanosoma cruzi, claims thousands of lives each year. Current diagnostic tools are insufficient to ensure parasitological detection in chronically infected patients has been achieved. A host-derived metab
Externí odkaz:
https://doaj.org/article/7e214d3ca7c3400e91be2e560fb097d5
Autor:
Kahina Chabi, Lekha Sleno
Publikováno v:
Metabolites, Vol 12, Iss 10, p 931 (2022)
Biotransformation reactions that xenobiotics undergo during their metabolism are crucial for their proper excretion from the body, but can also be a source of toxicity, especially in the case of reactive metabolite formation. Unstable, reactive metab
Externí odkaz:
https://doaj.org/article/7984e17a82a8402a89aae1201262004b
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Acetaminophen (APAP) is a mild analgesic and antipyretic used commonly worldwide. Although considered a safe and effective over-the-counter medication, it is also the leading cause of drug-induced acute liver failure. Its hepatotoxicity has been link
Externí odkaz:
https://doaj.org/article/06fd36888ef24557a5ac94525ff7c92c
Autor:
Ons Ousji, Lekha Sleno
Publikováno v:
Antioxidants, Vol 11, Iss 9, p 1635 (2022)
Synthetic gallic acid derivatives are employed as additives in food, personal care products, and pharmaceutical formulations. Despite their widespread use, little is known about their human exposure, health effects, and metabolism. Green tea catechin
Externí odkaz:
https://doaj.org/article/f81001e546ff4367bb3d2d36fc3e2731
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Acetaminophen (APAP)-induced hepatotoxicity is the most common cause of acute liver failure in the Western world. APAP is bioactivated to N-acetyl p-benzoquinone imine (NAPQI), a reactive metabolite, which can subsequently covalently bind to glutathi
Externí odkaz:
https://doaj.org/article/dc3964aa6e7c41cfaab652753cffc587
Autor:
Rym Boulfekhar, Leanne Ohlund, Kathrina Mae Kumaresan, Meriem Megoura, Thomas D. Warkentin, Pompilia Ispas-Szabo, Lekha Sleno, Mircea Alexandru Mateescu
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 5
Pages: 4625
Volume 24
Issue 5
Pages: 4625
Vegetal diamine oxidase (vDAO), an enzyme proposed to relieve symptoms of histaminosis, shows better reactivity with histamine and aliphatic diamines, as well as higher enzymatic activity than DAO of animal origin. The objective of this study was to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d68d5323e0e311c85c0e23c0021e38
Publikováno v:
Metabolites, Vol 10, Iss 1, p 26 (2020)
Bile acids represent a large class of steroid acids synthesized in the liver and further metabolized by many bacterial and mammalian enzymes. Variations in bile acid levels can be used as a measure of liver function. There still exists, however, a ne
Externí odkaz:
https://doaj.org/article/2847b6505899429dba6a1488fbc18772
Autor:
Andrew J. Percy, Jessica Tamura-Wells, Juan Pablo Albar, Kerman Aloria, Ardeshir Amirkhani, Gabriel D.T. Araujo, Jesus M. Arizmendi, Francisco J. Blanco, Francesc Canals, Jin-Young Cho, Núria Colomé-Calls, Fernando J. Corrales, Gilberto Domont, Guadalupe Espadas, Patricia Fernandez-Puente, Concha Gil, Paul A. Haynes, Maria Luisa Hernáez, Jin Young Kim, Arthur Kopylov, Miguel Marcilla, Mathew J. McKay, Mehdi Mirzaei, Mark P. Molloy, Leanne B. Ohlund, Young-Ki Paik, Alberto Paradela, Mark Raftery, Eduard Sabidó, Lekha Sleno, Daniel Wilffert, Justina C. Wolters, Jong Shin Yoo, Victor Zgoda, Carol E. Parker, Christoph H. Borchers
Publikováno v:
EuPA Open Proteomics, Vol 8, Iss C, Pp 6-15 (2015)
The reproducibility of plasma protein quantitation between laboratories and between instrument types was examined in a large-scale international study involving 16 laboratories and 19 LC–MS/MS platforms, using two kits designed to evaluate instrume
Externí odkaz:
https://doaj.org/article/3a68a7c1edbe473fa3c4d7fa483f95d3