Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Leiyun Weng"'
Autor:
Yuichi Hirata, Kazutaka Ikeda, Masayuki Sudoh, Yuko Tokunaga, Akemi Suzuki, Leiyun Weng, Masatoshi Ohta, Yoshimi Tobita, Ken Okano, Kazuhisa Ozeki, Kenichi Kawasaki, Takuo Tsukuda, Asao Katsume, Yuko Aoki, Takuya Umehara, Satoshi Sekiguchi, Tetsuya Toyoda, Kunitada Shimotohno, Tomoyoshi Soga, Masahiro Nishijima, Ryo Taguchi, Michinori Kohara
Publikováno v:
PLoS Pathogens, Vol 8, Iss 8, p e1002860 (2012)
Lipids are key components in the viral life cycle that affect host-pathogen interactions. In this study, we investigated the effect of HCV infection on sphingolipid metabolism, especially on endogenous SM levels, and the relationship between HCV repl
Externí odkaz:
https://doaj.org/article/f10c2408107f4af7ab3f1235190d2446
Autor:
Asako Murayama, Leiyun Weng, Tomoko Date, Daisuke Akazawa, Xiao Tian, Tetsuro Suzuki, Takanobu Kato, Yasuhito Tanaka, Masashi Mizokami, Takaji Wakita, Tetsuya Toyoda
Publikováno v:
PLoS Pathogens, Vol 6, Iss 4, p e1000885 (2010)
We have previously reported that the NS3 helicase (N3H) and NS5B-to-3'X (N5BX) regions are important for the efficient replication of hepatitis C virus (HCV) strain JFH-1 and viral production in HuH-7 cells. In the current study, we investigated the
Externí odkaz:
https://doaj.org/article/f6a9c9653b934510a177740b306138f2
Autor:
Junji Xing, Hongbo Lu, Li Jia, Yong-Jun Liu, Leiyun Weng, Zhuo Wang, Zhiqiang Zhang, Xian Chang Li, Rui Jin, Bin Yuan
Publikováno v:
Nature Immunology. 17:1373-1380
The respiratory tract is heavily populated with innate immune cells, but the mechanisms that control such cells are poorly defined. Here we found that the E3 ubiquitin ligase TRIM29 was a selective regulator of the activation of alveolar macrophages,
Autor:
Zhiqiang Zhang, Coline Tricot, Musheng Bao, Hiroki Mitoma, Yong-Jun Liu, Leiyun Weng, Ying Liu
Publikováno v:
The Journal of Immunology. 193:3676-3682
NLRP3 is a key component of caspase-activating macromolecular protein complexes called inflammasomes. It has been found that DHX33 is a cytosolic dsRNA sensor for the NLRP3 inflammasome, which induces caspase-1–dependent production of IL-1β and IL
Autor:
Murayama, Asako1, Leiyun Weng2, Date, Tomoko1, Akazawa, Daisuke1,3, Xiao Tian2, Suzuki, Tetsuro1, Kato, Takanobu1, Tanaka, Yasuhito4, Mizokami, Masashi5, Wakita, Takaji1 wakita@nih.go.jp, Toyoda, Tetsuya2 ttoyoda@sibs.ac.cn
Publikováno v:
PLoS Pathogens. Apr2010, Vol. 6 Issue 4, p1-11. 11p. 4 Graphs.
Autor:
Hongbo Lu, Musheng Bao, Joel Plumas, Peiqing Shi, Yong-Jun Liu, Shino Hanabuchi, York Wang, Ying Liu, Leiyun Weng, Zhiqiang Zhang, Laurence Chaperot, Wenwen Sha, Jun Qin
Publikováno v:
The Journal of Experimental Medicine
The transcription factor NFATC3 binds to IRF7 and to type 1 IFN promoters, regulating IRF7-mediated IFN expression in pDCs.
Plasmacytoid dendritic cells (pDCs) rapidly produce large amounts of type 1 interferon (IFN) after Toll-like receptor 7 a
Plasmacytoid dendritic cells (pDCs) rapidly produce large amounts of type 1 interferon (IFN) after Toll-like receptor 7 a
Effect of the methyltransferase domain of Japanese encephalitis virus NS5 on the polymerase activity
Autor:
Xiao Tian, Hidechika Okada, Jin Sun, Leiyun Weng, Vincent Deubel, Tetsuya Toyoda, Yingying Mao, Qiang Wang, Dorian Counor
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1819:411-418
Japanese encephalitis virus (JEV) NS5 consists of an N-terminal guanylyltransferase/methyltransferase (MTase) domain and a C-terminal RNA-dependent RNA polymerase (RdRp) domain. We purified JEV NS5 from bacteria and examined its RdRp activity in vitr
Publikováno v:
Gene. 496:79-87
Recently, we found that sphingomyelin bound and activated hepatitis C virus (HCV) 1b RNA polymerase (RdRp), thereby recruiting the HCV replication complex into lipid raft structures. Detergents are commonly used for resolving lipids and purifying pro
Publikováno v:
Virology. 422:214-223
The N-terminal amphipathic helix α 0 of hepatitis C virus (HCV) NS3 protein is an essential structural determinant for the protein membrane association. Here, we performed functional analysis to probe the role of this helix α 0 in the HCV life cycl
Autor:
Yves Jacob, Hongxing Hu, Shijian Zhang, Yidong Xu, Li Li, Hongbing Jiang, Qiang Wang, Tetsuya Toyoda, Leiyun Weng, Ying He, Baosen Jia
Publikováno v:
Antiviral Chemistry and Chemotherapy
Antiviral Chemistry and Chemotherapy, International Medical Press, 2011, 22 (3), pp.119-30. ⟨10.3851/IMP1902⟩
Antiviral Chemistry and Chemotherapy, 2011, 22 (3), pp.119-30. ⟨10.3851/IMP1902⟩
Antiviral Chemistry and Chemotherapy, International Medical Press, 2011, 22 (3), pp.119-30. ⟨10.3851/IMP1902⟩
Antiviral Chemistry and Chemotherapy, 2011, 22 (3), pp.119-30. ⟨10.3851/IMP1902⟩
Background: Because of high mutation rates, new drug-resistant viruses are rapidly evolving, thus making the necessary control of influenza virus infection difficult. Methods: We screened a constrained cysteine-rich peptide library mimicking μ-conot