Direct modulation of TRPM4 and TRPM3 channels by the phospholipase C inhibitor U73122

Autor: Leitner, MG, Michel, N, Behrendt, M, Dierich, M, Dembla, S, Wilke, BU, Konrad, M, Lindner, M, Oberwinkler, J, Oliver, D

BACKGROUND AND PURPOSE: Signalling through phospholipase C (PLC) controls many cellular processes. Much information on the relevance of this important pathway has been derived from pharmacological inhibition of the enzymatic activity of PLC. We found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4b88175b072fe70175135f09f9ce45d1
https://europepmc.org/articles/PMC4959952/

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Localization of the tubby domain, a PI(4,5)P2 biosensor, to E-Syt3-rich endoplasmic reticulum-plasma membrane junctions.

Autor: Thallmair V; Department of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps University Marburg, 35037 Marburg, Germany.; DFG Research Training Group, Membrane Plasticity in Tissue Development and Remodeling, GRK 2213, Philipps University Marburg, 35037 Marburg, Germany., Schultz L; Department of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps University Marburg, 35037 Marburg, Germany., Evers S; Department of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps University Marburg, 35037 Marburg, Germany., Jolie T; Department of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps University Marburg, 35037 Marburg, Germany., Goecke C; Department of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps University Marburg, 35037 Marburg, Germany., Leitner MG; Department of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps University Marburg, 35037 Marburg, Germany.; Institute of Physiology, Department of Physiology and Medical Physics, Medical University of Innsbruck, 6020 Innsbruck, Austria.; Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH&Co.KG, Birkendorfer Str. 65, 88400 Biberach an der Riß, Germany., Thallmair S; Frankfurt Institute for Advanced Studies, 60438 Frankfurt am Main, Germany.; Groningen Biomolecular Sciences and Biotechnology Institute and The Zernike Institute for Advanced Material, University of Groningen, 9747 AG Groningen, The Netherlands., Oliver D; Department of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps University Marburg, 35037 Marburg, Germany.; DFG Research Training Group, Membrane Plasticity in Tissue Development and Remodeling, GRK 2213, Philipps University Marburg, 35037 Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), Universities of Marburg and Giessen, 35032 Marburg, Germany.

Publikováno v: Journal of cell science [J Cell Sci] 2023 Aug 01; Vol. 136 (15). Date of Electronic Publication: 2023 Aug 04.

Optimized Tuning of Auditory Inner Hair Cells to Encode Complex Sound through Synergistic Activity of Six Independent K ⁺ Current Entities.

Autor: Dierich M; Department of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps-University Marburg, 35037 Marburg, Germany., Altoè A; Caruso Department of Otolaryngology, University of Southern California, Los Angeles, 90033 CA, USA., Koppelmann J; Department of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps-University Marburg, 35037 Marburg, Germany., Evers S; Department of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps-University Marburg, 35037 Marburg, Germany., Renigunta V; Department of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps-University Marburg, 35037 Marburg, Germany., Schäfer MK; Institute of Anatomy and Cell Biology, Philipps-University Marburg, 35037 Marburg, Germany; Center for Mind, Brain, and Behavior (CMBB), Universities of Marburg and Giessen, Marburg and Giessen, Germany., Naumann R; Max-Planck-Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany., Verhulst S; Hearing Technology at WAVES, Department of Information Technology, Ghent University, Technologiepark 126, 9052 Zwijnaarde, Belgium., Oliver D; Department of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps-University Marburg, 35037 Marburg, Germany; Center for Mind, Brain, and Behavior (CMBB), Universities of Marburg and Giessen, Marburg and Giessen, Germany; DFG Research Training Group, Membrane Plasticity in Tissue Development and Remodelling, GRK 2213, Philipps University, Marburg, Germany., Leitner MG; Institute of Physiology, Department of Physiology and Medical Physics, Medical University of Innsbruck, 6020 Innsbruck, Austria. Electronic address: michael.leitner@i-med.ac.at.

Publikováno v: Cell reports [Cell Rep] 2020 Jul 07; Vol. 32 (1), pp. 107869.

β-Secretase BACE1 Is Required for Normal Cochlear Function.

Autor: Dierich M; Institute of Physiology and Pathophysiology, Department of Neurophysiology, Philipps-University Marburg, 35037 Marburg, Germany., Hartmann S; Institut für Physiologie und Pathophysiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany., Dietrich N; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany., Moeser P; Institut für Physiologie und Pathophysiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany., Brede F; Institut für Physiologie und Pathophysiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany., Johnson Chacko L; Department of Otorhinolaryngology, Medical University of Innsbruck, 6020 Innsbruck, Austria., Tziridis K; Experimental Otolaryngology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany., Schilling A; Experimental Otolaryngology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany., Krauss P; Experimental Otolaryngology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany., Hessler S; Institut für Physiologie und Pathophysiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany., Karch S; Institut für Physiologie und Pathophysiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany., Schrott-Fischer A; Department of Otorhinolaryngology, Medical University of Innsbruck, 6020 Innsbruck, Austria., Blumer M; Division Clinical and Functional Anatomy, Medical University of Innsbruck, 6020 Innsbruck, Austria., Birchmeier C; Developmental Biology/Signal Transduction, Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany., Oliver D; Institute of Physiology and Pathophysiology, Department of Neurophysiology, Philipps-University Marburg, 35037 Marburg, Germany.; DFG Research Training Group, Membrane Plasticity in Tissue Development and Remodeling, GRK 2213, Philipps University, Germany.; Center for Mind, Brain and Behavior (CMBB), Universities of Marburg and Giessen, Germany, and., Moser T; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany., Schulze H; Experimental Otolaryngology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany., Alzheimer C; Institut für Physiologie und Pathophysiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany., Leitner MG; Institute of Physiology and Pathophysiology, Department of Neurophysiology, Philipps-University Marburg, 35037 Marburg, Germany, Michael.Leitner@i-med.ac.at Tobias.Huth@fau.de.; Institute of Physiology, Department of Physiology and Medical Physics, Medical University of Innsbruck, 6020 Innsbruck, Austria., Huth T; Institut für Physiologie und Pathophysiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany, Michael.Leitner@i-med.ac.at Tobias.Huth@fau.de.

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2019 Nov 06; Vol. 39 (45), pp. 9013-9027. Date of Electronic Publication: 2019 Sep 16.