Design and synthesis of naphthylchalcones as novel anti-leukaemia agents.

Autor: Leitão EPT; Process Chemistry Development, HovioneFarmaCiencia S.A., Estrada do Passo do Lumiar, Campus do Lumiar, Edificio S, 1649-038 Lisboa, Portugal. Electronic address: eleitao@hovione.com., Ascenso OS; Instituto de Tecnologia Química e Biológica, António Xavier, Universidade Nova de Lisboa, Apartado 127, 2780-901 Oeiras, Portugal., Santos de Almeida T; CBIOS - Universidade Lusófona's Research Center for Biosciences and Health Technologies, Campo Grande 376, 1749-024 Lisboa, Portugal., González I; Department of Biochemistry and Molecular Biology, Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), University of Las Palmas de Gran Canaria, Spain., Hernández I; Department of Biochemistry and Molecular Biology, Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), University of Las Palmas de Gran Canaria, Spain., Quintana J; Department of Biochemistry and Molecular Biology, Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), University of Las Palmas de Gran Canaria, Spain., Estévez F; Department of Biochemistry and Molecular Biology, Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), University of Las Palmas de Gran Canaria, Spain., Rijo P; CBIOS - Universidade Lusófona's Research Center for Biosciences and Health Technologies, Campo Grande 376, 1749-024 Lisboa, Portugal; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon (ULisboa), Lisbon, Portugal. Electronic address: patricia.rijo@ulusofona.pt.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2021 Dec; Vol. 117, pp. 105348. Date of Electronic Publication: 2021 Sep 21.