Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Leisa A. Glantz"'
Autor:
Dianne A. Cruz, Leisa A. Glantz, Kara D. McGaughey, Gillian Parke, Lawrence J. Shampine, Jason D. Kilts, Jennifer C. Naylor, Christine E. Marx, Douglas E. Williamson
Publikováno v:
Chronic Stress, Vol 3 (2019)
Background Neurosteroids mediate stress signaling and have been implicated in the pathogenesis of post-traumatic stress disorder (PTSD) in both preclinical and clinical studies. Compared to controls, subjects with PTSD exhibit altered neurosteroid le
Externí odkaz:
https://doaj.org/article/0c40ba6bded543bba18c7360d88a14c0
Publikováno v:
Neuroscience. 149:582-591
Previous studies of postnatal synaptic development in human frontal cortex have shown that synaptic density rises after birth, reaches a plateau in childhood and then decreases to adult levels by late adolescence. A similar pattern has been seen in n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdb507420cc4fc17e67a5421ebd6668e
https://doi.org/10.1016/j.neuroscience.2007.06.036
https://doi.org/10.1016/j.neuroscience.2007.06.036
Autor:
Thomas T. German, John H. Gilmore, Karissa L. Gable, Jeffrey A. Lieberman, L. Fredrik Jarskog, Leisa A. Glantz, Ruth I Tong
Publikováno v:
Neuropsychopharmacology. 32:95-102
In schizophrenia, studies indicate that apoptotic susceptibility in cortex may be increased. A role for apoptosis in schizophrenia could potentially contribute to post-mortem evidence of reduced cortical neuropil and neuroimaging studies showing prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060d5cb95a2e7162643aa2c383fafa8a
https://doi.org/10.1038/sj.npp.1301074
https://doi.org/10.1038/sj.npp.1301074
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 29:846-858
While schizophrenia is generally considered a neurodevelopmental disorder, evidence for progressive clinical deterioration and subtle neurostructural changes following the onset of psychosis has led to the hypothesis that apoptosis may contribute to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de7f8b5f77415706dfdc6111efa8af61
https://doi.org/10.1016/j.pnpbp.2005.03.010
https://doi.org/10.1016/j.pnpbp.2005.03.010
Publikováno v:
Annals of the New York Academy of Sciences. 1003:102-112
Multiple lines of evidence from pharmacological, neuroimaging, and postmortem studies implicate disturbances in cortical glutamate neurotransmission in the pathophysiology of schizophrenia. Given that pyramidal neurons are the principal source of cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::186481ddbb0fbea104cc74c2dbb87039
https://doi.org/10.1196/annals.1300.007
https://doi.org/10.1196/annals.1300.007
Publikováno v:
Biological Psychiatry. 48:389-397
Background: Previous studies have reported that the 38-kd synaptic vesicle-associated protein, synaptophysin, is decreased in the prefrontal cortex of subjects with schizophrenia. Methods: To determine whether the decreased protein levels reflect dim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f9c478b20e2944c84fb245c7e69dd8
https://doi.org/10.1016/s0006-3223(00)00923-9
https://doi.org/10.1016/s0006-3223(00)00923-9
Autor:
David H. Overstreet, John H. Gilmore, Leisa A. Glantz, L. Fredrik Jarskog, Jeffrey A. Lieberman, Kayvon Salimi
Although the etiology of schizophrenia remains unknown, diverse neuropathological evidence suggests a disorder of synaptic connectivity. Apoptosis is a form of cell death that helps determine synaptic circuitry during neurodevelopment and altered reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2342b741854c18d4d10eb015080fe3ad
Autor:
Kayvon Salimi, L. Fredrik Jarskog, Leisa A. Glantz, Robert M. Hamer, Thomas T. German, John H. Gilmore
Publikováno v:
Synapse (New York, N.Y.). 62(4)
Complexin 1 (CX1) and complexin 2 (CX2) are presynaptic proteins that modulate neurotransmitter release and are used as markers of inhibitory and excitatory synapses, respectively. The aim of this study was to gain insight into the development of inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2b47c15c691ccc486b058b483ffbe8
https://pubmed.ncbi.nlm.nih.gov/18240322
https://pubmed.ncbi.nlm.nih.gov/18240322
Publikováno v:
Schizophrenia research. 81(1)
The cortical neuropathology of schizophrenia includes neuronal atrophy, decreased neuropil, and alterations in neuronal density. Taken together with evidence of decreased synaptic markers and dendritic spines, the data suggest that synaptic circuitry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad848ac538e083a8b3447e04b7f96db
https://pubmed.ncbi.nlm.nih.gov/16226876
https://pubmed.ncbi.nlm.nih.gov/16226876
Publikováno v:
Annals of the New York Academy of Sciences. 1003
Multiple lines of evidence from pharmacological, neuroimaging, and postmortem studies implicate disturbances in cortical glutamate neurotransmission in the pathophysiology of schizophrenia. Given that pyramidal neurons are the principal source of cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b5112fb372c0d1a7ffabed1bb16fbe7e
https://pubmed.ncbi.nlm.nih.gov/14684438
https://pubmed.ncbi.nlm.nih.gov/14684438