Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-β-lactamases

Autor: Muhammad, Zeeshan, Skagseth, Susann, Boomgaren, Marc, Akhter, Sundus, Fröhlich, Christopher, Ismael, Aya, Christopeit, Tony, Bayer, Annette, Leiros, Hanna-Kirsti S.

Publikováno v: In Bioorganic & Medicinal Chemistry 1 August 2020 28(15)

Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase

Autor: Frøhlich, Christopher, Bunzel, H. Adrian, Buda, Karol, Mulholland, Adrian J., van der Kamp, Marc W., Johnsen, Pål Jarle, Leiros, Hanna-Kirsti S., Tokuriki, Nobuhiko

Publikováno v: Frøhlich, Bunzel, Buda, Mulholland, van der Kamp, Johnsen, Leiros, Tokuriki. Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase. Nature Catalysis. 2024

Externí odkaz: https://hdl.handle.net/10037/35166

A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design

Autor: Akhter, Sundus, Lund, Bjarte Aarmo, Ismael, Aya, Langer, Manuel, Isaksson, Johan, Christopeit, Tony, Leiros, Hanna-Kirsti S., Bayer, Annette

Publikováno v: In European Journal of Medicinal Chemistry 10 February 2018 145:634-648

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Metallo-β-lactamase inhibitors by bioisosteric replacement: Preparation, activity and binding

Autor: Skagseth, Susann, Akhter, Sundus, Paulsen, Marianne H., Muhammad, Zeeshan, Lauksund, Silje, Samuelsen, Ørjan, Leiros, Hanna-Kirsti S., Bayer, Annette

Publikováno v: In European Journal of Medicinal Chemistry 28 July 2017 135:159-173