Protein Tyrosine Phosphatases in Neuroblastoma: Emerging Roles as Biomarkers and Therapeutic Targets

Autor: Caroline E. Nunes-Xavier, Laura Zaldumbide, Lorena Mosteiro, Ricardo López-Almaraz, Nagore García de Andoin, Pablo Aguirre, Maite Emaldi, Leire Torices, José I. López, Rafael Pulido

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Neuroblastoma is a type of cancer intimately related with early development and differentiation of neuroendocrine cells, and constitutes one of the pediatric cancers with higher incidence and mortality. Protein tyrosine phosphatases (PTPs) are key re

Externí odkaz: https://doaj.org/article/ccca9838366a46f59182a2fbaa809b6e

Modeling human disease in yeast: recreating the PI3K-PTEN-Akt signaling pathway in Saccharomyces cerevisiae

Autor: Víctor J. Cid, Julia María Coronas-Serna, Marta Valenti, Elba del Val, Teresa Fernández-Acero, Isabel Rodríguez-Escudero, Rafael Pulido, Janire Mingo, María Molina, Leire Torices, Sandra Luna

Publikováno v: International Microbiology. 23:75-87

The yeast Saccharomyces cerevisiae is a model organism that has been thoroughly exploited to understand the universal mechanisms that govern signaling pathways. Due to its ease of manipulation, humanized yeast models that successfully reproduce the f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0b24c93bd8e82d34cd0909ab185fe8
https://doi.org/10.1007/s10123-019-00082-4

MMADHC premature termination codons in the pathogenesis of cobalamin D disorder: Potential of translational readthrough reconstitution

Autor: Javier de las Heras, Caroline E. Nunes-Xavier, Jesus M. Cortes, Juan Carlos Arango-Lasprilla, Rafael Pulido, Leire Torices

Publikováno v: Molecular Genetics and Metabolism Reports
Addi. Archivo Digital para la Docencia y la Investigación
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Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Molecular Genetics and Metabolism Reports, Vol 26, Iss, Pp 100710-(2021)

Mutations in the MMADHC gene cause cobalamin D disorder (cblD), an autosomal recessive inborn disease with defects in intracellular cobalamin (cbl, vitamin B12) metabolism. CblD patients present methylmalonic aciduria (MMA), homocystinuria (HC), or c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d723c7b1b4b30ae358c4a265c828e1b
https://pubmed.ncbi.nlm.nih.gov/33552904

Precise Immunodetection of PTEN Protein in Human Neoplasia

Autor: Ayman Gaafar, José I. López, Janire Mingo, Leire Torices, Caroline E. Nunes-Xavier, Sandra Luna, Javier C. Angulo, Rafael Pulido

Publikováno v: Cold Spring Harb Perspect Med

PTEN is a major tumor-suppressor protein whose expression and biological activity are frequently diminished in sporadic or inherited cancers. PTEN gene deletion or loss-of-function mutations favor tumor cell growth and are commonly found in clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1583ccc2961a36e7ee810f84dd5150b
https://europepmc.org/articles/PMC6886455/