Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Leire Borrega-Roman"'
Autor:
Jon Egaña-Huguet, Itziar Bonilla-Del Río, Sonia M. Gómez-Urquijo, Amaia Mimenza, Miquel Saumell-Esnaola, Leire Borrega-Roman, Gontzal García del Caño, Joan Sallés, Nagore Puente, Inmaculada Gerrikagoitia, Izaskun Elezgarai, Pedro Grandes
Publikováno v:
Frontiers in Neuroanatomy, Vol 15 (2021)
The transient receptor potential vanilloid 1 (TRPV1) is a non-selective ligand-gated cation channel involved in synaptic transmission, plasticity, and brain pathology. In the hippocampal dentate gyrus, TRPV1 localizes to dendritic spines and dendrite
Externí odkaz:
https://doaj.org/article/044de77a0285457c8e1802d58a4f5680
Autor:
Maider López de Jesús, Susana Mato, Sergio Barrondo, Xabier Aretxabala, Miquel Saumell-Esnaola, Catherine Ledent, Leire Borrega-Roman, Carlos Matute, Leyre Echeazarra, M.A. Goicolea, Imanol González-Burguera, Gontzal García del Caño, Joan Sallés
Publikováno v:
Histochemistry and Cell Biology
Specific and selective anti-CB1 antibodies are among the most powerful research tools to unravel the complex biological processes mediated by the CB1 receptor in both physiological and pathological conditions. However, low performance of antibodies r
Autor:
Thais Gazzi, Bradley L. Hoare, Stephen J. Hill, Stephen J. Briddon, Leire Borrega-Roman, David A. Sykes, Marc Nazaré, Clare R. Harwood, Steven J. Charlton, Uwe Grether, Jack M. Lochray, Dmitry B. Veprintsev
Publikováno v:
Biophysical and Computational Tools in Drug Discovery ISBN: 9783030852801
GPCR drug discovery medicinal chemistry programs are often driven by simple metrics such as affinity in the case of antagonists or efficacy in the case of agonists. Kinetic selectivity has been linked to fewer off-target side effects and improved eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41317745cdf575626660f6eac407f12e
https://doi.org/10.1007/7355_2021_120
https://doi.org/10.1007/7355_2021_120
Autor:
Miquel Saumell-Esnaola, Ainhoa Elejaga-Jimeno, Leyre Echeazarra, Leire Borrega-Román, Sergio Barrondo, Maider López de Jesús, Imanol González-Burguera, Alberto Gómez-Caballero, María Aranzazu Goicolea, Joan Sallés, Gontzal García del Caño
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-18 (2022)
Abstract Background Replacement of radioligand binding assays with antibody-antigen interaction-based approaches for quantitative analysis of G protein-coupled receptor (GPCR) levels requires the use of purified protein standards containing the antig
Externí odkaz:
https://doaj.org/article/f211edb5792742e6b82bbb1f53d75237
Autor:
Mireia Jiménez‐Rosés, Bradley Angus Morgan, Maria Jimenez Sigstad, Thuy Duong Zoe Tran, Rohini Srivastava, Asuman Bunsuz, Leire Borrega‐Román, Pattarin Hompluem, Sean A. Cullum, Clare R. Harwood, Eline J. Koers, David A. Sykes, Iain B. Styles, Dmitry B. Veprintsev
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 5, Pp n/a-n/a (2022)
Abstract G protein‐coupled receptors (GPCRs) are valuable therapeutic targets for many diseases. A central question of GPCR drug discovery is to understand what determines the agonism or antagonism of ligands that bind them. Ligands exert their act
Externí odkaz:
https://doaj.org/article/8c395ffb80f645bb9233171b8236b0df