Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Leire Aguinagalde"'
Autor:
Stian Foss, Siri A. Sakya, Leire Aguinagalde, Marta Lustig, Jutamas Shaughnessy, Ana Rita Cruz, Lisette Scheepmaker, Line Mathiesen, Fulgencio Ruso-Julve, Aina Karen Anthi, Torleif Tollefsrud Gjølberg, Simone Mester, Malin Bern, Mitchell Evers, Diane B. Bratlie, Terje E. Michaelsen, Tilman Schlothauer, Devin Sok, Jayanta Bhattacharya, Jeanette Leusen, Thomas Valerius, Sanjay Ram, Suzan H. M. Rooijakkers, Inger Sandlie, Jan Terje Andersen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Monoclonal IgG antibodies constitute the fastest growing class of therapeutics. Thus, there is an intense interest to design more potent antibody formats, where long plasma half-life is a commercially competitive differentiator affecting dos
Externí odkaz:
https://doaj.org/article/e2bf31ade1774fb9ab1a7bfa70490845
Autor:
Leire Aguinagalde Salazar, Maurits A den Boer, Suzanne M Castenmiller, Seline A Zwarthoff, Carla de Haas, Piet C Aerts, Frank J Beurskens, Janine Schuurman, Albert JR Heck, Kok van Kessel, Suzan HM Rooijakkers
Publikováno v:
eLife, Vol 12 (2023)
Streptococcus pneumoniae is the leading cause of community-acquired pneumonia and an important cause of childhood mortality. Despite the introduction of successful vaccines, the global spread of both non-vaccine serotypes and antibiotic-resistant str
Externí odkaz:
https://doaj.org/article/8d74be0a69284980be16130f15cd03bf
Autor:
Roberto Fuentes, Leire Aguinagalde, Carlo Pifferi, Adrián Plata, Nagore Sacristán, Donatello Castellana, Juan Anguita, Alberto Fernández-Tejada
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Vaccine adjuvants are key for optimal vaccine efficacy, increasing the immunogenicity of the antigen and potentiating the immune response. Saponin adjuvants such as the carbohydrate-based QS-21 natural product are among the most promising candidates
Externí odkaz:
https://doaj.org/article/018e92f40a3a4cb9a97640b50ff5af60
Publikováno v:
Vaccines, Vol 9, Iss 2, p 186 (2021)
The emergence of non-vaccine serotypes of Streptococcus pneumoniae after the use of vaccines based in capsular polysaccharides demonstrates the need of a broader protection vaccine based in protein antigens and widely conserved. In this study, we cha
Externí odkaz:
https://doaj.org/article/3706e1efafe149f4a277332a9cca1989
Autor:
Leire Aguinagalde, Bruno Corsini, Arnau Domenech, Mirian Domenech, Jordi Cámara, Carmen Ardanuy, Ernesto García, Josefina Liñares, Asunción Fenoll, Jose Yuste
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137565 (2015)
Capsular switching allows pre-existing clones of Streptococcus pneumoniae expressing vaccine serotypes to escape the vaccine-induced immunity by acquisition of capsular genes from pneumococci of a non-vaccine serotype. Here, we have analysed the clon
Externí odkaz:
https://doaj.org/article/a3d70285bff44e9883e3c3521c80bdd1
Autor:
Carlo Pifferi, Leire Aguinagalde, Ane Ruiz-de-Angulo, Nagore Sacristán, Priscila Tonon Baschirotto, Ana Poveda, Jesús Jiménez-Barbero, Juan Anguita, Alberto Fernández-Tejada
Publikováno v:
Chemical Science. 14:3501-3513
The overexpression of aberrantly glycosylated tumor-associated mucin-1 (TA-MUC1) in human cancers makes it a major target for the development of anticancer vaccines derived from synthetic MUC1-(glyco) peptide antigens. However, glycopeptide-based sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e1253a26a9d866cb63c83f9c0ce595
https://doi.org/10.1039/d2sc05639a
https://doi.org/10.1039/d2sc05639a
Akademický článek
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Autor:
Leire Aguinagalde Salazar, Maurits A den Boer, Suzanne M Castenmiller, Seline A Zwarthoff, Carla de Haas, Piet C Aerts, Frank J Beurskens, Janine Schuurman, Albert JR Heck, Kok van Kessel, Suzan HM Rooijakkers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02ffd4c65b9327092833fc86caac632e
https://doi.org/10.7554/elife.80669.sa2
https://doi.org/10.7554/elife.80669.sa2
Autor:
Josefina Liñares, Ernesto García, Arnau Domenech, Mirian Domenech, Asunción Fenoll, Jordi Càmara, Jose Yuste, Leire Aguinagalde, Carmen Ardanuy, Bruno Corsini
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Repisalud
Instituto de Salud Carlos III (ISCIII)
PLoS ONE, Vol 10, Iss 9, p e0137565 (2015)
PLoS ONE
Digital.CSIC. Repositorio Institucional del CSIC
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Repisalud
Instituto de Salud Carlos III (ISCIII)
PLoS ONE, Vol 10, Iss 9, p e0137565 (2015)
PLoS ONE
Digital.CSIC. Repositorio Institucional del CSIC
12 p.-5 fig.-1 tab.
Capsular switching allows pre-existing clones of Streptococcus pneumoniae expressing vaccine serotypes to escape the vaccine-induced immunity by acquisition of capsular genes from pneumococci of a non-vaccine serotype. Here,
Capsular switching allows pre-existing clones of Streptococcus pneumoniae expressing vaccine serotypes to escape the vaccine-induced immunity by acquisition of capsular genes from pneumococci of a non-vaccine serotype. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744b0be8530ee70c12c19cccbd495ef4
https://hdl.handle.net/20.500.12105/6988
https://hdl.handle.net/20.500.12105/6988
Publikováno v:
Chemical Communications (Cambridge, England)
We report the first synthesis and immunological evaluation of a new glycoconjugate design based on streamlined saponin adjuvants and the Tn carbohydrate antigen. While the novel synthetic constructs induced moderate antibody responses in mice, the ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e6a200df56088c43b1e917e6799adc