Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Leire Aguado"'
1
Akademický článek
Binding of glutathione to enterovirus capsids is essential for virion morphogenesis.
Autor: Hendrik Jan Thibaut, Lonneke van der Linden, Ping Jiang, Bert Thys, María-Dolores Canela, Leire Aguado, Bart Rombaut, Eckard Wimmer, Aniko Paul, María-Jesús Pérez-Pérez, Frank J M van Kuppeveld, Johan Neyts
Publikováno v: PLoS Pathogens, Vol 10, Iss 4, p e1004039 (2014)
Enteroviruses (family of the Picornaviridae) cover a large group of medically important human pathogens for which no antiviral treatment is approved. Although these viruses have been extensively studied, some aspects of the viral life cycle, in parti
Externí odkaz: https://doaj.org/article/3a31551959154d10b2a8714b46cf2715
Zobrazit plný text záznamu
2
Targeting HIV Entry through Interaction with Envelope Glycoprotein 120 (gp120): Synthesis and Antiviral Evaluation of 1,3,5-Triazines with Aromatic Amino Acids
Autor: Leire Aguado, Ana San-Félix, María-José Camarasa, Bart Hoorelbeke, Marleen Renders, Jan Balzarini, Dominique Schols, Virginia Lozano, María-Jesús Pérez-Pérez
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
On the basis of the interesting inhibitory properties that lectins show against HIV-replication through their interaction with glycoprotein 120 (gp120), we here describe the design, synthesis, and anti-HIV evaluation of three series of 1,3,5-triazine
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a3606792ea58bcce6201d63acf8871
https://doi.org/10.1021/jm200560r
Zobrazit plný text záznamu
5
9-Arylpurines as a novel class of enterovirus inhibitors
Autor: Johan Neyts, María-Luisa Jimeno, Leire Aguado, Hendrik Jan Thibaut, María-Jesús Pérez-Pérez, María-José Camarasa, Eva María Priego
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Here wereporton a novel class ofenterovirus inhibitors thatcan bestructurallydescribedas9-arylpurines. These compounds elicit activityagainst a varietyof enteroviruse s in the low μMrange including Coxsackie virus A16, A21, A24, Coxsackie virus B3,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802d9979b6d241fd8820c06cad22f1ee
https://pubmed.ncbi.nlm.nih.gov/19924996
Zobrazit plný text záznamu
7
Intramolecular Cation-π Interactions As the Driving Force To Restrict the Conformation of Certain Nucleosides
Autor: María-Jesús Pérez-Pérez, Leire Aguado, Elena Casanova, Andrea Negri, Eva-María Priego, María-Luisa Jimeno, Federico Gago, María-José Camarasa
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Despite the well-established importance of intermolecular cation-π interactions in molecular recognition, intramolecular cation-π interactions have been less studied. Here we describe how the simultaneous presence of an aromatic ring at the 50-posi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd7d3603c31389696e09d7f8d9ee548
http://hdl.handle.net/10261/34086
Zobrazit plný text záznamu
8
Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule 'crystallization chaperone' 5'-O-tritylinosine (KIN59)
Autor: Sandra Liekens, Jan Balzarini, Annelies Bronckaers, M-J Pérez-Pérez, Andrea Negri, Leire Aguado, M J Camarasa, Federico Gago
Publikováno v: e_Buah Biblioteca Digital Universidad de Alcalá
instname
Digital.CSIC. Repositorio Institucional del CSIC
Thymidine phosphorylase (TP) is a catabolic enzyme in thymidine metabolism that is frequently upregulated in many solid tumors. Elevated TP levels are associated with tumor angiogenesis, metastasis and poor prognosis. Therefore, the use of TP inhibit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace380339f1ecb08c2ec2a0a080aad8f
https://hdl.handle.net/10017/5046
Zobrazit plný text záznamu
10
7,5'-O-dibenzylinosines: synthesis and studies on their conformational properties
Autor: Federico Gago, Leire Aguado, María-Jesús Pérez-Pérez, Elena Casanova, María-Luisa Jimeno, María-José Camarasa
Publikováno v: Nucleosides, nucleotidesnucleic acids. 26(6-7)
Reaction of 2′,3′-O-isopropylidene inosine with benzyl bromide (1 h, rt) led to the 1,5′-O-dibenzylderivative 4, but by increasing the reaction time or the temperature, compound 4 is further transformed into the 1,7,5′-O-tribenzylinosine deri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5492fb40900fdaed7b61a222d126c64
https://pubmed.ncbi.nlm.nih.gov/18066882
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje