Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Leiping Zeng"'
Autor:
Leiping Zeng, Yanxia Liu, Xammy Huu Nguyenla, Timothy R. Abbott, Mengting Han, Yanyu Zhu, Augustine Chemparathy, Xueqiu Lin, Xinyi Chen, Haifeng Wang, Draven A. Rane, Jordan M. Spatz, Saket Jain, Arjun Rustagi, Benjamin Pinsky, Adrianna E. Zepeda, Anastasia P. Kadina, John A. Walker, Kevin Holden, Nigel Temperton, Jennifer R. Cochran, Annelise E. Barron, Michael D. Connolly, Catherine A. Blish, David B. Lewis, Sarah A. Stanley, Marie F. La Russa, Lei S. Qi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
A major challenge in coronavirus vaccination and treatment is to counteract rapid viral evolution and mutations. Here the authors show that CRISPR-Cas13d can be used as a broad-spectrum antiviral to inhibit human coronaviruses, including new SARS-CoV
Externí odkaz:
https://doaj.org/article/b19524c1f85b4105af7741efdca8ff41
Autor:
Xuelian Cui, Chao Zhang, Zhifang Xu, Shuaibin Wang, Xin Li, Erica Stringer-Reasor, Sejong Bae, Leiping Zeng, Dehua Zhao, Runhua Liu, Lei S. Qi, Lizhong Wang
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-8 (2022)
Abstract Background Unlike autosomal tumor suppressors, X-linked tumor suppressors can be inactivated by a single hit due to X-chromosome inactivation (XCI). Here, we argue that targeted reactivation of the non-mutated allele from XCI offers a potent
Externí odkaz:
https://doaj.org/article/dea985c9f6d341e8bdb5741fc637b3d9
Autor:
Madeline J. Lee, Michelle W. Leong, Arjun Rustagi, Aimee Beck, Leiping Zeng, Susan Holmes, Lei S. Qi, Catherine A. Blish
Publikováno v:
Cell reports.
SummaryNatural killer (NK) cells are cytotoxic effector cells that target and lyse virally-infected cells; many viruses therefore encode mechanisms to escape such NK cell killing. Here, we interrogated the ability of SARS-CoV-2 to modulate NK cell re
Autor:
Anish R. Roy, Jiarui Wang, Mengting Han, Haifeng Wang, Leonhard Möckl, Leiping Zeng, William E. Moerner, Lei S. Qi
Publikováno v:
Biophysical Journal. 122:16a
Autor:
Lei S. Qi, Zhifang Xu, Xuelian Cui, Lizhong Wang, Dehua Zhao, Shuaibin Wang, Erica Stringer-Reasor, Runhua Liu, Sejong Bae, Xin Li, Leiping Zeng
Unlike autosomal tumor suppressors, which must be inactivated by a two-hit Knudson mechanism, X-linked tumor suppressors can be inactivated by a single hit due to X-chromosome inactivation (XCI). Here, we argue that targeted reactivation of the non-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0a825b6a2f6671a61b313099cd5c256
https://doi.org/10.1101/2021.08.14.456310
https://doi.org/10.1101/2021.08.14.456310
Autor:
Xuelian Cui, Chao Zhang, Zhifang Xu, Shuaibin Wang, Xin Li, Erica Stringer-Reasor, Sejong Bae, Leiping Zeng, Dehua Zhao, Runhua Liu, Lei S. Qi, Lizhong Wang
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-8 (2022)
Background Unlike autosomal tumor suppressors, X-linked tumor suppressors can be inactivated by a single hit due to X-chromosome inactivation (XCI). Here, we argue that targeted reactivation of the non-mutated allele from XCI offers a potential thera
Autor:
Mengting Han, Lei S. Qi, Jiarui Wang, Leiping Zeng, Haifeng Wang, Leonhard K. R. Moeckl, W. E. Moerner
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
Cell Reports Methods
article-version (status) pre
article-version (number) 1
Cell Reports Methods
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third human coronavirus within 20 years that gave rise to a life-threatening disease and the first to reach pandemic spread. To make therapeutic headway against current and futur
The Chinese horseshoe bat (Rhinolophus sinicus), reservoir host of severe acute respiratory syndrome coronavirus (SARS-CoV), carries many bat SARS-related CoVs (SARSr-CoVs) with high genetic diversity, particularly in the spike gene. Despite these va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797032b5f2bd4266a124bc96194b0eba
https://doi.org/10.1101/2020.05.13.093658
https://doi.org/10.1101/2020.05.13.093658
Publikováno v:
Journal of Virology
Evolutionary arms race dynamics shape the diversity of viruses and their receptors. Identification of key residues which are involved in interspecies transmission is important to predict potential pathogen spillover from wildlife to humans. Previousl
Autor:
Nicholas S. Heaton, Robert J. Debs, Girija Dhamdhere, Leiping Zeng, Drew Endy, Tara Pande, Marie La Russa, David B. Lewis, Lei S. Qi, Laine E. Goudy, Augustine Chemparathy, Yanxia Liu, Stephen Chmura, Timothy R. Abbott, Xueqiu Lin
The outbreak of the coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), has infected more than 100,000 people worldwide with over 3,000 deaths since December 2019. There is no cure for COVI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d72f63d2187eb900abad2055862ecf