Výsledky vyhledávání - "Leina Lunasco"

Akademický článek

OCT-Derived Radiomic Features Predict Anti–VEGF Response and Durability in Neovascular Age-Related Macular Degeneration

Autor: Sudeshna Sil Kar, PhD, Hasan Cetin, MD, Leina Lunasco, BA, Thuy K. Le, BA, Robert Zahid, PharmD, Xiangyi Meng, PhD, Sunil K. Srivastava, MD, Anant Madabhushi, PhD, Justis P. Ehlers, MD

Publikováno v: Ophthalmology Science, Vol 2, Iss 4, Pp 100171- (2022)

Purpose: No established biomarkers currently exist for therapeutic efficacy and durability of anti–VEGF therapy in neovascular age-related macular degeneration (nAMD). This study evaluated radiomic-based quantitative OCT biomarkers that may be pred

Externí odkaz: https://doaj.org/article/6dbdac2e90124dd9821541509e5e2592

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Akademický článek

Computational Imaging Biomarker Correlation with Intraocular Cytokine Expression in Diabetic Macular Edema

Autor: Sudeshna Sil Kar, PhD, Joseph Abraham, MD, Charles C. Wykoff, MD, PhD, Duriye Damla Sevgi, MD, Leina Lunasco, BS, David M. Brown, MD, Sunil K. Srivastava, MD, Anant Madabhushi, PhD, Justis P. Ehlers, MD

Publikováno v: Ophthalmology Science, Vol 2, Iss 2, Pp 100123- (2022)

Purpose: Various pathways and cytokines are implicated in pathogenesis of diabetic macular edema (DME). Computational imaging biomarkers (CIBs) of vessel tortuosity from ultra-widefield fluorescein angiography (UWFA) and texture patterns from OCT ima

Externí odkaz: https://doaj.org/article/b1f9b7e001b1400987697cf9fe886866

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Risk Classification for Progression to Subfoveal Geographic Atrophy in Dry Age-Related Macular Degeneration Using Machine Learning–Enabled Outer Retinal Feature Extraction

Autor: Kubra Sarici, Joseph R. Abraham, Duriye Damla Sevgi, Leina Lunasco, Sunil K. Srivastava, Jon Whitney, Hasan Cetin, Annapurna Hanumanthu, Jordan M. Bell, Jamie L. Reese, Justis P. Ehlers

Publikováno v: Ophthalmic Surgery, Lasers and Imaging Retina. 53:31-39

BACKGROUND AND OBJECTIVE: To evaluate the utility of spectral-domain optical coherence tomography biomarkers to predict the development of subfoveal geographic atrophy (sfGA). PATIENTS AND METHODS: This was a retrospective cohort analysis including 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3c75afd1be87ef1059b08d9eefa366
https://doi.org/10.3928/23258160-20211210-01

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Exploring the angiographic-biologic phenotype in the IMAGINE study: quantitative UWFA and cytokine expression

Autor: Charles C. Wykoff, Jamie Reese, Sruthi Arepalli, Joseph R Abraham, Hannah J. Yu, Ming Hu, Justis P. Ehlers, Sunil K. Srivastava, Alison Martin, Leina Lunasco, Christopher J. Mugnaini, David M. Brown

Publikováno v: British Journal of Ophthalmology. 106:1444-1449

BackgroundThis study investigates the association of intraocular cytokine expression and ultrawide-field fluorescein angiography (UWFA) quantitative imaging biomarkers and their association with angiographical feature response after antivascular endo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01690abbab6022a2a34718a5f90e056e
https://doi.org/10.1136/bjophthalmol-2020-318726

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Aqueous Cytokine Expression and Higher Order OCT Biomarkers: Assessment of the Anatomic-Biologic Bridge in the IMAGINE DME Study

Autor: Sunil K. Srivastava, Leina Lunasco, Sruthi Arepalli, Jamie Reese, Hannah J. Yu, Joseph R Abraham, Justis P. Ehlers, David M. Brown, Charles C. Wykoff, Ming Hu

Publikováno v: Am J Ophthalmol

Purpose To identify biomarkers for predicting response to anti−vascular endothelial growth factor (VEGF) therapy in diabetic macular edema (DME) and evaluate any links between cytokine expression and optical coherence tomography (OCT) phenotype. De

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781d613ad2336ddfab38d09f14d52b28
https://doi.org/10.1016/j.ajo.2020.08.047

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Machine Learning-Based Automated Detection and Quantification of Geographic Atrophy and Hypertransmission Defects Using Spectral Domain Optical Coherence Tomography

Autor: Gagan Kalra, Hasan Cetin, Jon Whitney, Sari Yordi, Yavuz Cakir, Conor McConville, Victoria Whitmore, Michelle Bonnay, Leina Lunasco, Antoine Sassine, Kevin Borisiak, Daniel Cohen, Jamie Reese, Sunil K. Srivastava, Justis. P. Ehlers

Publikováno v: Journal of Personalized Medicine; Volume 13; Issue 1; Pages: 37

The current study describes the development and assessment of innovative, machine learning (ML)-based approaches for automated detection and pixel-accurate measurements of regions with geographic atrophy (GA) in late-stage age-related macular degener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c272974f508f9714010e683910d074
https://doi.org/10.3390/jpm13010037

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Longitudinal analysis of aqueous humour cytokine expression and OCT-based imaging biomarkers in retinal vein occlusions treated with anti-vascular endothelial growth factor therapy in the IMAGINE study

Autor: Sruthi, Arepalli, Charles C, Wykoff, Joseph R, Abraham, Leina, Lunasco, Hannah, Yu, Ming, Hu, Sunil K, Srivastava, Jamie L, Reese, David, Brown, Justis P, Ehlers

Publikováno v: Eye (London, England).

Retinal vein occlusion (RVO) is the second most common retinal vascular disorder. Despite promising advances with anti-VEGF therapy, select patients are unresponsive to therapy. A precision medicine-based approach for therapeutic decision-making base

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2d3d8b9a3f36c5835330487c327c878e
https://pubmed.ncbi.nlm.nih.gov/36220884

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Quantitative Ultra-Widefield Angiography and Diabetic Retinopathy Severity

Autor: Thuy K Le, Jenna Hach, Katherine Talcott, Amy Babiuch, Alison Rogozinski, Sunil K. Srivastava, Joseph Boss, Leina Lunasco, Natalia Figueiredo, Sumit Sharma, Justis P. Ehlers, Jamie Reese, Alice C. Jiang, Ming Hu

Publikováno v: Ophthalmology. 126:1527-1532

Purpose To investigate the relationship between the diabetic retinopathy (DR) severity and quantitative ultra-widefield angiographic metrics, including leakage index, ischemic index, and microaneurysm count. Design Retrospective image analysis study.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c38679091911197185b746daea0d062
https://doi.org/10.1016/j.ophtha.2019.05.034

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