Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: Example lists & criteria for their selection & use

Autor: Aschner, M, Ceccatelli, S, Daneshian, M, Fritsche, E, Hasiwa, N, Hartung, T, Hogberg, HT, Leist, M, Li, A, Mundy, WR, Padilla, S, Piersma, AH, Bal-Price, A, Seiler, A, Westerink, RH, Zimmer, B, Lein, PJ

Publikováno v: Aschner, M; Ceccatelli, S; Daneshian, M; Fritsche, E; Hasiwa, N; Hartung, T; et al.(2017). Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: Example lists & criteria for their selection & use. Altex, 34(1), 49-74. doi: 10.14573/altex.1604201. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/6b40t0t5

There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard posed by industrial and environmental chemicals. New testing approaches will most likely be based on batteries of alternative and complementary (non-Animal) tes

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Mechanisms of Reduced Astrocyte Surface Coverage in Cortical Neuron-Glia Co-cultures on Nanoporous Gold Surfaces

Autor: Chapman, CAR, Chen, H, Stamou, M, Lein, PJ, Seker, E

Publikováno v: Chapman, Christopher A. R; Chen, Hao; Stamou, Marianna; Lein, Pamela J; & Seker, Erkin. (2016). Mechanisms of Reduced Astrocyte Surface Coverage in Cortical Neuron-Glia Co-cultures on Nanoporous Gold Surfaces. Cellular and Molecular Bioengineering. doi: 10.1007/s12195-016-0449-4. UC Office of the President: UC Lab Fees Research Program (LFRP); a funding opportunity through UC Research Initiatives (UCRI). Retrieved from: http://www.escholarship.org/uc/item/4qh7j3hd
Chapman, CAR; Chen, H; Stamou, M; Lein, PJ; & Seker, E. (2016). Mechanisms of Reduced Astrocyte Surface Coverage in Cortical Neuron-Glia Co-cultures on Nanoporous Gold Surfaces. Cellular and Molecular Bioengineering, 9(3), 433-442. doi: 10.1007/s12195-016-0449-4. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/7t9393p2

© 2016, Biomedical Engineering Society. Nanoporous gold (np-Au) is a promising multifunctional material for neural electrodes. We have previously shown that np-Au nanotopography reduces astrocyte surface coverage (linked to undesirable gliosis) whil

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Tetramethylenedisulfotetramine

Autor: Banks, CN, Yang, D, Lein, PJ, Rogawski, MA

Tetramethylenedisulfotetramine (CAS 80-12-6), commonly referred to as TETS, was first synthesized in 1933 as a condensation product of sulfamide and formaldehyde. TETS was subsequently used as a rodenticide until banned worldwide in 1991. TETS is, ho

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Fetal Alcohol Spectrum Disorder: Targeted Effects of Ethanol on Cell Proliferation and Survival

Autor: Mooney, SM, Lein, PJ, Miller, MW

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Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons

Autor: Beck, HN, Drahushuk, K, Jacoby, DB, Higgins, D, Lein, PJ

Publikováno v: BMC neuroscience, vol 2, iss 1
Beck, HN; Drahushuk, K; Jacoby, DB; Higgins, D; & Lein, PJ. (2001). Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons.. BMC neuroscience, 2(1), 12. doi: 10.1186/1471-2202-2-12. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/58s0p5qc

BackgroundBMP-5 is expressed in the nervous system throughout development and into adulthood. However its effects on neural tissues are not well defined. BMP-5 is a member of the 60A subgroup of BMPs, other members of which have been shown to stimula

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