Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Leiling Pan"'
Autor:
Leiling Pan, Medhanie A. Mulaw, Johann Gout, Min Guo, Hina Zarrin, Peggy Schwarz, Bernd Baumann, Thomas Seufferlein, Martin Wagner, Franz Oswald
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 5, Pp 783-807 (2023)
Background and Aims: Development of pancreatic ductal adenocarcinoma (PDAC) is a multistep process intensively studied; however, precocious diagnosis and effective therapy still remain unsatisfactory. The role for Notch signaling in PDAC has been dis
Externí odkaz:
https://doaj.org/article/04e3fa24650a4a80b4d92d4f238b50c0
Autor:
Francesca Ferrante, Benedetto Daniele Giaimo, Tobias Friedrich, Toshiya Sugino, Daniel Mertens, Sabrina Kugler, Bernd Martin Gahr, Steffen Just, Leiling Pan, Marek Bartkuhn, Michael Potente, Franz Oswald, Tilman Borggrefe
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-9 (2022)
Abstract Notch signaling plays a pivotal role in the development and, when dysregulated, it contributes to tumorigenesis. The amplitude and duration of the Notch response depend on the posttranslational modifications (PTMs) of the activated NOTCH rec
Externí odkaz:
https://doaj.org/article/e94caf3b118449feae916a319b8e5115
Autor:
Hartmut Döhner, Stephan Stilgenbauer, Sabrina Kugler, Eugen Tausch, Deyan Y. Yosifov, Johannes Bloehdorn, Mike-Andrew Westhoff, Michaela Reichenzeller, Franz Oswald, Daniel Mertens, Viola Close, William Close, Leiling Pan
Publikováno v:
Blood. 133:830-839
NOTCH1 is mutated in 10% of chronic lymphocytic leukemia (CLL) patients and is associated with poor outcome. However, NOTCH1 activation is identified in approximately one-half of CLL cases even in the absence of NOTCH1 mutations. Hence, there appear
Autor:
Kerstin Hein, Benedetto Daniele Giaimo, Franz Oswald, Tilman Borggrefe, Bradley D. VanderWielen, Rhett A. Kovall, Aleksandra Turkiewicz, Zhenyu Yuan, Leiling Pan, Courtney E. Collins
The Notch pathway is a conserved signaling mechanism that is essential for cell fate decisions during pre and postnatal development. Dysregulated signaling underlies the pathophysiology of numerous human diseases, most notably T-cell acute lymphoblas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b900510db34ae166c3938d9c76e06b7d
Autor:
Tilman Borggrefe, Leiling Pan, Bradley D. VanderWielen, Zhenyu Yuan, Franz Oswald, Kerstin Hein, Rhett A. Kovall, Aleksandra Turkiewicz, Courtney E. Collins, Benedetto Daniele Giaimo
Publikováno v:
Cell reports
SUMMARY Notch is a conserved signaling pathway that is essential for metazoan development and homeostasis; dysregulated signaling underlies the pathophysiology of numerous human diseases. Receptor-ligand interactions result in gene expression changes
Autor:
Mike-Andrew Westhoff, Deyan Y. Yosifov, Sabrina Kugler, William Close, Leiling Pan, Viola Close, Michaela Reichenzeller, Franz Oswald, Johannes Bloehdorn, Daniel Mertens, Eugen Tausch, Stephan Stilgenbauer, Hartmut Döhner
Publikováno v:
Blood. 132:946-946
Background Oncogenic proteins can be stabilized either via genetic mutations or via defects in the ubiquitin ligating- and degradation machinery. NOTCH1 protein stability is affected by genetic mutations in approximately 10% of chronic lymphocytic le