Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Leilei Zhong"'
Autor:
Lue FANG, Sitao ZHU, Shidong LI, Fangfang WANG, Zhen KONG, Guangfei ZHOU, Tengfei YUAN, Leilei ZHONG, Guanglin PENG
Publikováno v:
Meikuang Anquan, Vol 55, Iss 7, Pp 110-117 (2024)
Based on the rock burst occurrence of the south water sump connecting roadway in the seventh mining area of Zhaolou Coal Mine, the mechanism of creep instability rock burst of high stress isolated coal immersed in water was studied by means of theore
Externí odkaz:
https://doaj.org/article/1028f9c48bfc4a7689eacfd534901c61
Autor:
Lutian Yao, Jiawei Lu, Leilei Zhong, Yulong Wei, Tao Gui, Luqiang Wang, Jaimo Ahn, Joel D Boerckel, Danielle Rux, Christina Mundy, Ling Qin, Maurizio Pacifici
Publikováno v:
eLife, Vol 12 (2023)
Insufficient bone fracture repair represents a major clinical and societal burden and novel strategies are needed to address it. Our data reveal that the transforming growth factor-β superfamily member Activin A became very abundant during mouse and
Externí odkaz:
https://doaj.org/article/e2afbc82a06e4e92a58094be629da842
Autor:
Leilei Zhong, Jiawei Lu, Jiankang Fang, Lutian Yao, Wei Yu, Tao Gui, Michael Duffy, Nicholas Holdreith, Catherine A Bautista, Xiaobin Huang, Shovik Bandyopadhyay, Kai Tan, Chider Chen, Yongwon Choi, Jean X Jiang, Shuying Yang, Wei Tong, Nathanial Dyment, Ling Qin
Publikováno v:
eLife, Vol 12 (2023)
Colony-stimulating factor 1 (Csf1) is an essential growth factor for osteoclast progenitors and an important regulator for bone resorption. It remains elusive which mesenchymal cells synthesize Csf1 to stimulate osteoclastogenesis. We recently identi
Externí odkaz:
https://doaj.org/article/bb1b12b6a7ed4afd8c68a366c9066d9a
Autor:
Leilei Zhong, Lutian Yao, Nicholas Holdreith, Wei Yu, Tao Gui, Zhen Miao, Yehuda Elkaim, Mingyao Li, Yanqing Gong, Maurizio Pacifici, Amit Maity, Theresa M. Busch, Kyu Sang Joeng, Keith Cengel, Patrick Seale, Wei Tong, Ling Qin
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
Radiation causes a collapse of bone marrow cells and elimination of microvasculature. To understand how bone marrow recovers after radiation, we focused on mesenchymal lineage cells that provide a supportive microenvironment for hematopoiesis and ang
Externí odkaz:
https://doaj.org/article/3e4aca805ba8470286d4476776986427
Autor:
Sakshi Khurana, Stefano Schivo, Jacqueline R. M. Plass, Nikolas Mersinis, Jetse Scholma, Johan Kerkhofs, Leilei Zhong, Jaco van de Pol, Rom Langerak, Liesbet Geris, Marcel Karperien, Janine N. Post
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
A fundamental question in cartilage biology is: what determines the switch between permanent cartilage found in the articular joints and transient hypertrophic cartilage that functions as a template for bone? This switch is observed both in a subset
Externí odkaz:
https://doaj.org/article/7987b8cda5b64370984e24d6236274bd
Autor:
Yulong Wei, Hao Sun, Tao Gui, Lutian Yao, Leilei Zhong, Wei Yu, Su-Jin Heo, Lin Han, Nathaniel A Dyment, Xiaowei Sherry Liu, Yejia Zhang, Eiki Koyama, Fanxin Long, Miltiadis H Zgonis, Robert L Mauck, Jaimo Ahn, Ling Qin
Publikováno v:
eLife, Vol 10 (2021)
Meniscal tears are associated with a high risk of osteoarthritis but currently have no disease-modifying therapies. Using a Gli1 reporter line, we found that Gli1+ cells contribute to the development of meniscus horns from 2 weeks of age. In adult mi
Externí odkaz:
https://doaj.org/article/f623562d2d094d8fa2bb24d452a21fa8
Autor:
Leilei Zhong, Lutian Yao, Robert J Tower, Yulong Wei, Zhen Miao, Jihwan Park, Rojesh Shrestha, Luqiang Wang, Wei Yu, Nicholas Holdreith, Xiaobin Huang, Yejia Zhang, Wei Tong, Yanqing Gong, Jaimo Ahn, Katalin Susztak, Nathanial Dyment, Mingyao Li, Fanxin Long, Chider Chen, Patrick Seale, Ling Qin
Publikováno v:
eLife, Vol 9 (2020)
Bone marrow mesenchymal lineage cells are a heterogeneous cell population involved in bone homeostasis and diseases such as osteoporosis. While it is long postulated that they originate from mesenchymal stem cells, the true identity of progenitors an
Externí odkaz:
https://doaj.org/article/e1bde3bf4480496eb8cd45466e510294
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 8, Pp 19225-19247 (2015)
Hypertrophic differentiation of chondrocytes is a main barrier in application of mesenchymal stem cells (MSCs) for cartilage repair. In addition, hypertrophy occurs occasionally in osteoarthritis (OA). Here we provide a comprehensive review on recent
Externí odkaz:
https://doaj.org/article/38007833d64144b48b4d21b31924f562
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 2, p 561 (2018)
Mesenchymal stem cells (MSCs) are multipotent cells, mainly from bone marrow, and an ideal source of cells in bone and cartilage tissue engineering. A study of the chondrogenic differentiation of MSCs is of particular interest for MSCs-based cartilag
Externí odkaz:
https://doaj.org/article/ac82510bbc5c4b54ba661dd98f9ca07d
Autor:
Leilei Zhong, Stefano Schivo, Xiaobin Huang, Jeroen Leijten, Marcel Karperien, Janine N. Post
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 11, p 2491 (2017)
Interleukin 1 beta (IL1β) and Wingless-Type MMTV Integration Site Family (WNT) signaling are major players in Osteoarthritis (OA) pathogenesis. Despite having a large functional overlap in OA onset and development, the mechanism of IL1β and WNT cro
Externí odkaz:
https://doaj.org/article/524d3cc51bb44d3cb5d76651d109413a