Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Leilani A. Ramos"'
Autor:
Maria Tomasz, Arunangshu Das, Leilani A. Ramos, Cristina C. Clement, Ashis K. Basu, Christopher Utzat
Publikováno v:
Chemical Research in Toxicology. 18:213-223
Mitomycin C (MC) is a cytotoxic and mutagenic antitumor agent that alkylates and cross-links DNA. These effects are dependent on reductive bioactivation of MC. 2,7-Diaminomitosene (2,7-DAM) is the major metabolite of MC in tumor cells, generated by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bed3b0772893160e3f237a60e7af8e7
https://doi.org/10.1021/tx049813h
https://doi.org/10.1021/tx049813h
Autor:
Govind Kalena, Jane M. Sayer, Anthony Dipple, Ingrid Ponten, Haruhiko Yagi, Leilani A. Ramos, Subodh Kumar, Heiko Kroth, Donald M. Jerina
Publikováno v:
Chemical Research in Toxicology. 15:1619-1626
Although there have been numerous studies of site-specific mutagenesis by dGuo adducts of benzo[a]pyrene diol epoxides (B[a]P DEs), the present study represents the first example of site-specific mutagenesis by dGuo adducts of the highly carcinogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1030e7c93fe8c6a3b97955fada38320
https://doi.org/10.1021/tx020073r
https://doi.org/10.1021/tx020073r
Autor:
Jane M. Sayer, Ingrid Pontén, Myron F. Goodman, Anthony Dipple, Leilani A. Ramos, Govind Kalena, Heiko Kroth, Haruhiko Yagi, Donald M. Jerina
Publikováno v:
Polycyclic Aromatic Compounds. 22:871-879
Eight isomeric dGuo and eight dAdo adducts resulting from cis and trans opening of each of the four optically active diol epoxides (DEs) derived from benzo[ a ]pyrene (B a P) and benzo[ c ]phenanthrene (B c Ph) were placed in each of two 16-mer DNA s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de13f0efaa7037755500c7395f49d318
https://doi.org/10.1080/10406630290104022
https://doi.org/10.1080/10406630290104022
Publikováno v:
Chemical Research in Toxicology. 11:64-69
To determine the mutagenic and genotoxic properties of the major guanine N2-adduct formed by the antitumor drug mitomycin C, we have synthesized a decanucleotide, d(TTACGMCTATCT), containing the adduct, which was inserted into a gapped bacteriophage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5158596bbfc898fcb40b1813634b74f0
https://doi.org/10.1021/tx970163+
https://doi.org/10.1021/tx970163+
Publikováno v:
Biochemistry. 32:12793-12801
The mutagenic and genotoxic properties of 1,N6-ethenoadenine (epsilon Ade), 3,N4-ethenocytosine (epsilon Cyt), and 4-amino-5-(imidazol-2-yl)imidazole (beta) were investigated in vivo. The former two modified bases are known DNA adducts formed by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c54b5741b91bb23614310e360c327f6
https://doi.org/10.1021/bi00210a031
https://doi.org/10.1021/bi00210a031
Autor:
Haruhiko Yagi, Jamshed H. Shah, Leilani A. Ramos, Anthony Dipple, Donald M. Jerina, Jane M. Sayer
Publikováno v:
Chemical research in toxicology. 14(8)
We have previously investigated the mutations induced on replication in Escherichia coli of the M13mp7L2 genome containing each of the eight possible adducts derived from the four optically active 7,8-diol 9,10-epoxide metabolites of benzo[a]pyrene (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4b616d438f218fbf83f6c981447ee7
https://pubmed.ncbi.nlm.nih.gov/11511182
https://pubmed.ncbi.nlm.nih.gov/11511182