PMEL Amyloid Fibril Formation: The Bright Steps of Pigmentation

Autor: Christin Bissig, Leila Rochin, Guillaume van Niel

Publikováno v: International Journal of Molecular Sciences, Vol 17, Iss 9, p 1438 (2016)

In pigment cells, melanin synthesis takes place in specialized organelles, called melanosomes. The biogenesis and maturation of melanosomes is initiated by an unpigmented step that takes place prior to the initiation of melanin synthesis and leads to

Externí odkaz: https://doaj.org/article/fef7aa4b825c43459ad82097c123a6fe

ORP5/8 and MIB/MICOS link ER-mitochondria and intra-mitochondrial contacts for non-vesicular transport of phosphatidylserine

Autor: David Tareste, Vera F Monteiro-Cardoso, Francesca Giordano, Audrey Houcine, Annukka M. Kivelä, Eyra Marien, Romain Le Bars, Naima El Khallouki, Elena Santonico, Eeva Jääskeläinen, Leila Rochin, Vesa M. Olkkonen, Johannes V. Swinnen, Jonas Dehairs, Amita Arora, Julie Neveu, Cécile Sauvanet

Publikováno v: Cell reports. 40(12)

Mitochondria are dynamic organelles essential for cell survival whose structural and functional integrity rely on selective and regulated transport of lipids from/to the endoplasmic reticulum (ER) and across the mitochondrial intermembrane space. As

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec2dd8377eb2330ee8ffe7582425684
https://pubmed.ncbi.nlm.nih.gov/36130504

Chemical targeting of NEET proteins reveals their function in mitochondrial morphodynamics

Autor: Ahmed Hamaï, Nivea Dias Amoedo, Francesca Giordano, Yang Sung Sohn, Peter Machin, Benoît de Chassey, Diana Molino, Patrice Codogno, Ola Karmi, Henri-Baptiste Marjault, Laetitia Lines, Irene Pila-Castellanos, Alessia Ruggieri, Damien Arnoult, Pauline Radreau, Rodrigue Rossignol, Etienne Morel, Eric Meldrum, Leila Rochin, Jacky Vonderscher, Rachel Nechushtai, Stéphane Joly, Katja Kopp

Publikováno v: EMBO Rep
EMBO Reports
EMBO Reports, EMBO Press, 2020, 21 (12), ⟨10.15252/embr.201949019⟩
EMBO Reports, EMBO Press, 2020, ⟨10.15252/embr.201949019⟩

International audience; Several human pathologies including neurological, cardiac, infectious , cancerous, and metabolic diseases have been associated with altered mitochondria morphodynamics. Here, we identify a small organic molecule, which we name

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05b0954eedbb6d731ad6194e35c1b2c
https://pubmed.ncbi.nlm.nih.gov/33180995

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

Autor: Ragna, Sannerud, Cary, Esselens, Paulina, Ejsmont, Rafael, Mattera, Leila, Rochin, Arun Kumar, Tharkeshwar, Greet, De Baets, Veerle, De Wever, Roger, Habets, Veerle, Baert, Wendy, Vermeire, Christine, Michiels, Arjan J, Groot, Rosanne, Wouters, Katleen, Dillen, Katlijn, Vints, Pieter, Baatsen, Sebastian, Munck, Rita, Derua, Etienne, Waelkens, Guriqbal S, Basi, Mark, Mercken, Marc, Vooijs, Mathieu, Bollen, Joost, Schymkowitz, Frederic, Rousseau, Juan S, Bonifacino, Guillaume, Van Niel, Bart, De Strooper, Wim, Annaert

γ-Secretases are a family of intramembrane-cleaving proteases involved in various signaling pathways and diseases, including Alzheimer's disease (AD). Cells co-express differing γ-secretase complexes, including two homologous presenilins (PSENs). W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c5c028d17b3d033e77b773331674704a
https://lirias.kuleuven.be/handle/123456789/544673

BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells

Autor: Michael S. Marks, Guillaume van Niel, Ilse Hurbain, Bart De Strooper, Leila Rochin, Cecile Fort, Graça Raposo, Brenda Watt, Pascal Leblanc, Lutgarde Serneels

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2013, 110 (26), pp.10658-10663. ⟨10.1073/pnas.1220748110⟩

Amyloids are often associated with pathologic processes such as in Alzheimer’s disease (AD), but can also underlie physiological processes such as pigmentation. Formation of pathological and functional amyloidogenic substrates can require precursor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2968026497eb4de7c1830e27d133da9
https://europepmc.org/articles/PMC3696817/