Výsledky vyhledávání - "Leila Robinson"

Determining How Stem‐loop Structure Thermodynamic Stability Influences Frameshift Efficiency at the HTLV‐1 gag‐pro Frameshift Site

Autor: Mary Soliman, Leila Robinson, Madison Maille, Carolyn Egekeze, Rebecca Salamon, Kathryn D. Mouzakis

Publikováno v: The FASEB Journal. 36

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fe5e44949a3b68311f4562dec5352bf
https://doi.org/10.1096/fasebj.2022.36.s1.l6403

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Abstract 3479: UBTF tandem duplications (UBTF-TD) in childhood AML: Enrichment in FLT3-ITD and association with clinical outcome

Autor: Leila Robinson, Amanda Leonti, Todd A. Alonzo, Yi-Cheng Wang, Michele S. Redell, Rhonda E. Ries, Jenny L. Smith, Tiffany A. Hylkema, Quy Le, E Anders Kolb, Richard Aplenc, Xiaotu Ma, Jeffrey Klco, Katherine Tarlock, Soheil Meshinchi

Publikováno v: Cancer Research. 82:3479-3479

Childhood AML is an aggressive disease with high rates of failures and poor survival. We have demonstrated that the molecular landscape of AML in children is distinct, and co-occurrence of variants modulate outcomes. Recent discovery of tandem duplic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa72585cddb97002712373552f59cd3e
https://doi.org/10.1158/1538-7445.am2022-3479

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Biology and Clinical Implications of Complex Landscape of Cooperating Events in FLT3-ITD Acute Myeloid Leukemia

Autor: E. Anders Kolb, Quy Le, Xiaotu Ma, Jenny L. Smith, Richard Aplenc, Todd A. Alonzo, Tiffany A. Hylkema, Jessica A. Pollard, Katherine Tarlock, Leila Robinson, Yi-Cheng Wang, Amanda R. Leonti, Robert B. Gerbing, Rhonda E. Ries, Soheil Meshinchi

Publikováno v: Blood. 138:3454-3454

FLT3-ITD mutations are among the most common somatic mutations in acute myeloid leukemia (AML) and are important in prognostic determination as well as therapeutic allocation. Recent studies have demonstrated improved outcomes with the addition of FL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9fccd8dbd1a4e6e605101d677c284175
https://doi.org/10.1182/blood-2021-153703

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KMT2A Partial Tandem Duplications (KMT2A-PTD) Is a Rare, but Recurrent Genomic Event in Childhood AML and Associated with High Rate of Co-Occurring FLT3 Mutations

Autor: Soheil Meshinchi, Richard Aplenc, Danielle C. Kirkey, Anders Kolb, Quang Tran, Xiaotu Ma, Yanling Liu, Amanda R. Leonti, Todd A. Alonzo, Jenny L. Smith, Quy Le, Rhonda E. Ries, Jessica A. Pollard, Leila Robinson, Katherine Tarlock, Yi-Cheng Wang

Publikováno v: Blood. 138:609-609

KMT2A partial tandem duplication (KMT2A-PTD), characterized by a large internal duplication spanning 6-8 exons, has been documented in adult AML with a prevalence of 3-10% and is associated with poor outcomes. Despite the high prevalence of KTM2A fus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::297f3e4523c21e5198ba74c403161fcc
https://doi.org/10.1182/blood-2021-147565

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