Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Leila Reyes"'
Autor:
Leila Reyes, Manuel A. Sanchez-Garcia, Tyler Morrison, Andy J. M. Howden, Emily R. Watts, Simone Arienti, Pranvera Sadiku, Patricia Coelho, Ananda S. Mirchandani, Ailiang Zhang, David Hope, Sarah K. Clark, Jo Singleton, Shonna Johnston, Robert Grecian, Azin Poon, Sarah McNamara, Isla Harper, Max Head Fourman, Alejandro J. Brenes, Shalini Pathak, Amy Lloyd, Giovanny Rodriguez Blanco, Alex von Kriegsheim, Bart Ghesquiere, Wesley Vermaelen, Camila T. Cologna, Kevin Dhaliwal, Nik Hirani, David H. Dockrell, Moira K. B. Whyte, David Griffith, Doreen A. Cantrell, Sarah R. Walmsley
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus disease 2019 (COVID-19). Neutrophils play a key ro
Externí odkaz:
https://doaj.org/article/69dfb1e9146244cb9d8db5194cef99af
Autor:
Leila Reyes, Manuel A. Sanchez-Garcia, Tyler Morrison, Andy J. M. Howden, Emily R. Watts, Simone Arienti, Pranvera Sadiku, Patricia Coelho, Ananda S. Mirchandani, Ailiang Zhang, David Hope, Sarah K. Clark, Jo Singleton, Shonna Johnston, Robert Grecian, Azin Poon, Sarah McNamara, Isla Harper, Max Head Fourman, Alejandro J. Brenes, Shalini Pathak, Amy Lloyd, Giovanny Rodriguez Blanco, Alex von Kriegsheim, Bart Ghesquiere, Wesley Vermaelen, Camila T. Cologna, Kevin Dhaliwal, Nik Hirani, David H. Dockrell, Moira K. B. Whyte, David Griffith, Doreen A. Cantrell, Sarah R. Walmsley
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus disease 2019 (COVID-19). Neutrophils play a key ro
Externí odkaz:
https://doaj.org/article/fdf252eb205a4660a9cdfc932717fe99
Autor:
Ananda S. Mirchandani, Stephen J. Jenkins, Calum C. Bain, Manuel A. Sanchez-Garcia, Hannah Lawson, Patricia Coelho, Fiona Murphy, David M. Griffith, Ailiang Zhang, Tyler Morrison, Tony Ly, Simone Arienti, Pranvera Sadiku, Emily R. Watts, Rebecca. S. Dickinson, Leila Reyes, George Cooper, Sarah Clark, David Lewis, Van Kelly, Christos Spanos, Kathryn M. Musgrave, Liam Delaney, Isla Harper, Jonathan Scott, Nicholas J. Parkinson, Anthony J. Rostron, J. Kenneth Baillie, Sara Clohisey, Clare Pridans, Lara Campana, Philip Starkey Lewis, A. John Simpson, David H. Dockrell, Jürgen Schwarze, Nikhil Hirani, Peter J. Ratcliffe, Christopher W. Pugh, Kamil Kranc, Stuart J. Forbes, Moira K. B. Whyte, Sarah R. Walmsley
Publikováno v:
Mirchandani, A S, Jenkins, S J, Bain, C C, Sanchez Garcia, M A, Lawson, H, Coelho, P, Murphy, F, Griffith, D, Zhang, A, Morrison, T, Ly, T, Arienti, S, Sadiku, P, Watts, E R, Dickinson, R, Reyes, L, Cooper, G, Clark, S, Lewis, D, Kelly, V, Spanos, C, Musgrave, K M, Delaney, L, Harper, I, Scott, J, Parkinson, N, Rostron, A J, Baillie, J K, Clohisey, S, Pridans, C, Campana, L, Starkey Lewis, P, Simpson, A J, Dockrell, D H, Schwarze, J, Hirani, N, Ratcliffe, P J, Pugh, C W, Kranc, K, Forbes, S J, Whyte, M K B & Walmsley, S R 2022, ' Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation ', Nature Immunology . https://doi.org/0.1038/s41590-022-01216-z
Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, yet the resulting tissue hypoxia, and its impact on immune responses, is often neglected. In the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ab39b51379ba91e60afdc26dc1fbd1
https://doi.org/10.1038/s41590-022-01216-z
https://doi.org/10.1038/s41590-022-01216-z
Publikováno v:
Current Cardiology Reports. 24:445-461
Purpose of Review Exciting pre-clinical data presents pluripotent stem cell-derived cardiomyocytes (PSC-CM) as a novel therapeutic prospect following myocardial infarction, and worldwide clinical trials are imminent. However, despite notable advances
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa5cc02836f6defd2456d35f4d47b85
https://doi.org/10.1007/s11886-022-01666-9
https://doi.org/10.1007/s11886-022-01666-9
Autor:
Ananda S. Mirchandani, Stephen J. Jenkins, Calum C. Bain, Hannah Lawson, Patricia Coelho, Fiona Murphy, David Griffith, Ailiang Zhang, Manuel A. Sanchez-Garcia, Leila Reyes, Tyler Morrison, Simone Arienti, Pranvera Sadiku, Emily R. Watts, Rebecca. S. Dickinson, Sarah Clark, Tony Ly, David Lewis, Van Kelly, Christos Spanos, Kathryn M. Musgrave, Liam Delaney, Isla Harper, Jonathan Scott, Nicholas J. Parkinson, Anthony J. Rostron, Kenneth J Baillie, Sara Clohisey, Clare Pridans, Lara Campana, Philip Starkey-Lewis, A John Simpson, David Dockrell, Jurgen Schwarze, Nikhil Hirani, Peter J. Ratcliffe, Christopher W. Pugh, Kamil Kranc, Stuart J. Forbes, Moira K. Whyte, Sarah R. Walmsley
Acute Respiratory Distress Syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, has no cure. Hypoxemia is a defining feature, yet its impact on inflammation is often neglected. Patients with ARDS are monocytopenic early
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd0c7273ae0a2fc5433d47bed192db4f
https://doi.org/10.1101/2022.03.11.483935
https://doi.org/10.1101/2022.03.11.483935
Publikováno v:
Archives of Biochemistry and Biophysics. 665:132-142
Oxidative stress is a major hallmark of cardiac ischemia/reperfusion (I/R) injury, which is in part due to the release of the enzyme myeloperoxidase (MPO) from activated infiltrating leukocytes, and the subsequent production of the oxidants hypochlor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd778e896319e08becb25ac47943e76a
https://doi.org/10.1016/j.abb.2019.03.004
https://doi.org/10.1016/j.abb.2019.03.004
Autor:
Ananda S. Mirchandani, Stephen J. Jenkins, Calum C. Bain, Manuel A. Sanchez-Garcia, Hannah Lawson, Patricia Coelho, Fiona Murphy, David M. Griffith, Ailiang Zhang, Tyler Morrison, Tony Ly, Simone Arienti, Pranvera Sadiku, Emily R. Watts, Rebecca. S. Dickinson, Leila Reyes, George Cooper, Sarah Clark, David Lewis, Van Kelly, Christos Spanos, Kathryn M. Musgrave, Liam Delaney, Isla Harper, Jonathan Scott, Nicholas J. Parkinson, Anthony J. Rostron, J. Kenneth Baillie, Sara Clohisey, Clare Pridans, Lara Campana, Philip Starkey Lewis, A. John Simpson, David H. Dockrell, Jürgen Schwarze, Nikhil Hirani, Peter J. Ratcliffe, Christopher W. Pugh, Kamil Kranc, Stuart J. Forbes, Moira K. B. Whyte, Sarah R. Walmsley
Publikováno v:
Nature Immunology. 23:1394-1394
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bdb316411bc622d8d23464d169eacef
https://doi.org/10.1038/s41590-022-01286-z
https://doi.org/10.1038/s41590-022-01286-z
Autor:
Patrícia Coelho, Pranvera Sadiku, Alex von Kriegsheim, Leila Reyes, David H. Dockrell, Robert Grecian, Jordi Duran, Christopher J Graham, Simone Arienti, Abel Acosta-Sanchez, Veronica M. Dardé, Privjyot Jheeta, Ananda S. Mirchandani, Gordon G. Paterson, A. A. Roger Thompson, David Sammut, Tyler Morrison, Martin A. Bewley, Ailing Zhang, Joseph A Willson, Massimiliano Mazzone, Kenneth Baillie, Moira K. B. Whyte, Tobias Griessler, Sarah R. Walmsley, Emily R. Watts, Peter Carmeliet, Jessie-May Morgan, Eilise M. Ryan, John P. Thomson, Manuel A. Sanchez Garcia, Bart Ghesquière, Joan J. Guinovart, Richard R. Meehan, Gio Rodriguez-Blanco, Jason M. Young
Publikováno v:
Sadiku, P, Willson, J A, Ryan, E M, Sammut, D, Coelho, P, Watts, E R, Grecian, R, Young, J M, Bewley, M, Arienti, S, Mirchandani, A S, Sanchez Garcia, M A, Morrison, T, Zhang, A, Reyes, L, Griessler, T, Jheeta, P, Paterson, G G, Graham, C J, Thompson, J P, Baillie, K, Thompson, A A R, Morgan, J-M, Acosta-Sanchez, A, Dardé, V M, Duran, J, Guinovart, J J, Rodriguez-Blanco, G, Von Kriegsheim, A, Meehan, R R, Mazzone, M, Dockrell, D H, Ghesquiere, B, Carmeliet, P, Whyte, M K B & Walmsley, S R 2021, ' Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis ', Cell Metabolism, vol. 33, no. 2, pp. 411-423.e4 . https://doi.org/10.1016/j.cmet.2020.11.016
Cell Metabolism
Cell Metabolism
Summary Neutrophils can function and survive in injured and infected tissues, where oxygen and metabolic substrates are limited. Using radioactive flux assays and LC-MS tracing with U-13C glucose, glutamine, and pyruvate, we observe that neutrophils
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cad74cc910e5a97db33fae4b7012689
https://eprints.whiterose.ac.uk/169130/1/1-s2.0-S1550413120306513-main.pdf
https://eprints.whiterose.ac.uk/169130/1/1-s2.0-S1550413120306513-main.pdf
Autor:
Leila Reyes, Patrícia Coelho, Pranvera Sadiku, Tyler Morrison, Moira K. B. Whyte, Giulia Rinaldi, Simone Arienti, David H. Dockrell, Joseph A Willson, Sarah R. Walmsley
Publikováno v:
Blood
Willson, J A, Arienti, S, Sadiku, P, Reyes, L, Coelho, P, Morrison, T, Rinaldi, G, Dockrell, D H, Whyte, M K B & Walmsley, S R 2021, ' Neutrophil HIF-1α stabilisation is augmented by mitochondrial ROS produced via the glycerol 3-phosphate shuttle ', Blood . https://doi.org/10.1182/blood.2021011010
Willson, J A, Arienti, S, Sadiku, P, Reyes, L, Coelho, P, Morrison, T, Rinaldi, G, Dockrell, D H, Whyte, M K B & Walmsley, S R 2021, ' Neutrophil HIF-1α stabilisation is augmented by mitochondrial ROS produced via the glycerol 3-phosphate shuttle ', Blood . https://doi.org/10.1182/blood.2021011010
Neutrophils are predominantly glycolytic cells that derive little ATP from oxidative phosphorylation; however, they possess an extensive mitochondrial network and maintain a mitochondrial membrane potential. Although studies have shown neutrophils ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2a7e83827ebda2ac67ec90a4f68fb8
https://pubmed.ncbi.nlm.nih.gov/35024809
https://pubmed.ncbi.nlm.nih.gov/35024809
Autor:
Shalini Pathak, Emily R. Watts, Manuel A. Sanchez-Garcia, Ananda S. Mirchandani, Azin Poon, Camila Takeno Cologna, Max Head Fourman, Moira K. B. Whyte, David M Griffith, David Hope, Sarah McNamara, Sarah K. Clark, Andrew J. M. Howden, Gio Rodriguez Blanco, Alejandro Brenes, Doreen A. Cantrell, Amy Lloyd, Kevin Dhaliwal, Isla Harper, Ailiang Zhang, Alex von Kriegsheim, Pranvera Sadiku, Nik Hirani, Leila Reyes, Tyler Morrison, Wesley Vermaelen, Shonna Johnston, Simone Arienti, David H. Dockrell, Sarah R. Walmsley, Patrícia Coelho, Jo Singleton, Bart Ghesquière, Robert Grecian
SummaryUnderstanding the mechanisms by which infection with SARS-CoV-2 leads to acute respiratory distress syndrome (ARDS) is of significant clinical interest given the mortality associated with severe and critical coronavirus induced disease 2019 (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e7d5021cb67033540b4680668a75c93
https://doi.org/10.1101/2020.09.15.20195305
https://doi.org/10.1101/2020.09.15.20195305