Variations of SOST mRNA expression in human bone are associated with DNA polymorphism and DNA methylation in the SOST gene

Autor: Diana Zelenika, Frédéric Jehan, Valérie Geoffroy, Anne Boland, Agnès Ostertag, Leila Lhaneche, Didier Hannouche, Bente L. Langdahl, Aline Domingues, Martine Cohen-Solal, Jannie Dahl Hald, Marc Delepine, Marie-Christine de Vernejoul, Torben Harsløf

Publikováno v: Lhaneche, L, Domingues, A, Hannouche, D, Delepine, M, Zelenika, D, Boland, A, Ostertag, A, Cohen-Solal, M, Langdahl, B L, Harsløf, T, de Vernejoul, M-C, Geoffroy, V & Jehan, F 2016, ' Variations of SOST mRNA expression in human bone are associated with DNA polymorphism and DNA methylation in the SOST gene ', Bone, vol. 92, pp. 107-115 . https://doi.org/10.1016/j.bone.2016.08.004

SOST encodes sclerostin, an inhibitor of bone formation that antagonizes canonical Wnt signaling. Variations of SOST expression have an impact on bone mineral density (BMD) and bone strength. We hypothesized that genetic and epigenetic DNA modificati

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https://pubmed.ncbi.nlm.nih.gov/27519970