Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Leila Akkari"'
Autor:
Christel F. A. Ramirez, Daniel Taranto, Masami Ando-Kuri, Marnix H. P. de Groot, Efi Tsouri, Zhijie Huang, Daniel de Groot, Roelof J. C. Kluin, Daan J. Kloosterman, Joanne Verheij, Jing Xu, Serena Vegna, Leila Akkari
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Myeloid cells are abundant and plastic immune cell subsets in the liver, to which pro-tumorigenic, inflammatory and immunosuppressive roles have been assigned in the course of tumorigenesis. Yet several aspects underlying their dynamic alter
Externí odkaz:
https://doaj.org/article/8fdb0db866fb4b6fba788951b3b0d68b
Autor:
Antonio Mulero‐Sánchez, Christel F. A. Ramirez, Aimée duChatinier, Hui Wang, Sofie J. I. Koomen, Ji‐Ying Song, Marnix H. P. deGroot, Cor Lieftink, Astrid Bosma, Artur Burylo, Olaf vanTellingen, Roderick L. Beijersbergen, Cun Wang, Leila Akkari, René Bernards, Sara Mainardi
Publikováno v:
Molecular Oncology, Vol 17, Iss 6, Pp 964-980 (2023)
Liver cancer is the fourth most common cause of cancer‐related death worldwide, with hepatocellular carcinoma (HCC) being the main primary malignancy affecting the liver. Unfortunately, there are still limited therapeutic options for HCC, and even
Externí odkaz:
https://doaj.org/article/127c0b27e58a4e90916c39f950995ed1
Autor:
Mueez Waqar, Federico Roncaroli, Ibrahim Djoukhadar, Leila Akkari, Claire O'Leary, Lauren Hewitt, Gabriella Forte, Richard Jackson, Eline Hessen, Lisa Withington, William Beasley, Jenny Richardson, Christopher Golby, Philip Whitehurst, Rovel Colaco, Matthew Bailey, Konstantina Karabatsou, Pietro I. D'Urso, Catherine McBain, David J. Coope, Gerben R. Borst
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 39, Iss , Pp 100585- (2023)
Background: Glioblastoma is a high-grade aggressive neoplasm whose outcomes have not changed in decades. In the current treatment pathway, tumour growth continues and remains untreated for several weeks post-diagnosis. Intensified upfront therapy cou
Externí odkaz:
https://doaj.org/article/a0c1d9a40fee4794b2b2595cd357ed30
Ras/MAPK signalling intensity defines subclonal fitness in a mouse model of hepatocellular carcinoma
Autor:
Anthony Lozano, Francois-Régis Souche, Carine Chavey, Valérie Dardalhon, Christel Ramirez, Serena Vegna, Guillaume Desandre, Anaïs Riviere, Amal Zine El Aabidine, Philippe Fort, Leila Akkari, Urszula Hibner, Damien Grégoire
Publikováno v:
eLife, Vol 12 (2023)
Quantitative differences in signal transduction are to date an understudied feature of tumour heterogeneity. The MAPK Erk pathway, which is activated in a large proportion of human tumours, is a prototypic example of distinct cell fates being driven
Externí odkaz:
https://doaj.org/article/a6847e4afd534521b7463f84208c628a
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Tumor-associated macrophages (TAMs) are a major component of the tumor immune microenvironment (TIME) and are associated with a poor prognostic factor in several cancers. TAMs promote tumor growth by facilitating immunosuppression, angiogenesis, and
Externí odkaz:
https://doaj.org/article/b4e7477ff3b7496b8b0c2e3a21ae32a5
Autor:
Anna Prudova, Vasilena Gocheva, Ulrich auf dem Keller, Ulrich Eckhard, Oakley C. Olson, Leila Akkari, Georgina S. Butler, Nikolaus Fortelny, Philipp F. Lange, Jennifer C. Mark, Johanna A. Joyce, Christopher M. Overall
Publikováno v:
Cell Reports, Vol 16, Iss 6, Pp 1762-1773 (2016)
Deregulated cathepsin proteolysis occurs across numerous cancers, but in vivo substrates mediating tumorigenesis remain ill-defined. Applying 8-plex iTRAQ terminal amine isotopic labeling of substrates (TAILS), a systems-level N-terminome degradomics
Externí odkaz:
https://doaj.org/article/175b1854b1184aa8a8318d1d641e7b94
Autor:
Yannick Simonin, Serena Vegna, Leila Akkari, Damien Grégoire, Etienne Antoine, Jacques Piette, Nicolas Floc'h, Patrice Lassus, Guann-Yi Yu, Arielle R Rosenberg, Michael Karin, David Durantel, Urszula Hibner
Publikováno v:
PLoS Pathogens, Vol 9, Iss 3, p e1003234 (2013)
Exposure to hepatitis C virus (HCV) typically results in chronic infection that leads to progressive liver disease ranging from mild inflammation to severe fibrosis and cirrhosis as well as primary liver cancer. HCV triggers innate immune signaling w
Externí odkaz:
https://doaj.org/article/aba6c2c467324ee39aea21eea458e347
Autor:
Nicolas Floc'h, Jakub Kolodziejski, Leila Akkari, Yannick Simonin, Stéphane Ansieau, Alain Puisieux, Urszula Hibner, Patrice Lassus
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72490 (2013)
Expression of developmental genes Twist1 and Twist2 is reactivated in many human tumors. Among their oncogenic activities, induction of epithelial to mesenchymal transition is believed to increase cell motility and invasiveness and may be related to
Externí odkaz:
https://doaj.org/article/b2d23ee5fc534f148181b316840bb382
Autor:
Luuk van Hooren, Shanna M. Handgraaf, Daan J. Kloosterman, Elham Karimi, Lotte W.H.G. van Mil, Awa A. Gassama, Beatriz Gomez Solsona, Marnix H. P. de Groot, Dieta Brandsma, Daniela F. Quail, Logan A. Walsh, Gerben R. Borst, Leila Akkari
Publikováno v:
Nature Cancer. 4:665-681
Glioblastomas are aggressive primary brain tumors with an inherent resistance to T cell-centric immunotherapy due to their low mutational burden and immunosuppressive tumor microenvironment. Here we report that fractionated radiotherapy of preclinica
Autor:
Elham Karimi, Miranda W. Yu, Sarah M. Maritan, Lucas J. M. Perus, Morteza Rezanejad, Mark Sorin, Matthew Dankner, Parvaneh Fallah, Samuel Doré, Dongmei Zuo, Benoit Fiset, Daan J. Kloosterman, LeeAnn Ramsay, Yuhong Wei, Stephanie Lam, Roa Alsajjan, Ian R. Watson, Gloria Roldan Urgoiti, Morag Park, Dieta Brandsma, Donna L. Senger, Jennifer A. Chan, Leila Akkari, Kevin Petrecca, Marie-Christine Guiot, Peter M. Siegel, Daniela F. Quail, Logan A. Walsh
Publikováno v:
Nature. 614:555-563
Single-cell technologies have enabled the characterization of the tumour microenvironment at unprecedented depth and have revealed vast cellular diversity among tumour cells and their niche. Anti-tumour immunity relies on cell–cell relationships wi