Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Leila, Malik"'
Autor:
Thomas Hoeg-Jensen, Lasse Sander Dreyer, Leila Malik, Rasmus Høiberg-Nielsen, Jesper Nygaard, Lise Arleth
Publikováno v:
Molecular Pharmaceutics. 17:2809-2820
B29Ne-lithocholyl-γ-l-βGlu-desB30 human insulin [NN344] belongs to a group of insulins with fatty acid or sterol modifications. These insulin analogues have been found to form subcutaneous depots upon injection and hereby have a protracted release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcd5aa2aca0fe15a6d06f2e89877822
https://doi.org/10.1021/acs.molpharmaceut.0c00112
https://doi.org/10.1021/acs.molpharmaceut.0c00112
Autor:
Jesper Nygaard, Werner Streicher, Leila Malik, Knud J. Jensen, Niels Johan Christensen, Lise Arleth, Peter W. Thulstrup
Publikováno v:
Journal of Peptide Science. 19:283-292
alpha-Helical coiled coil structures, which are noncovalently associated heptad repeat peptide sequences, are ubiquitous in nature. Similar amphipathic repeat sequences have also been found in helix-containing proteins and have played a central role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c5595a6040bb3adaa2a3d6912f03532
https://doi.org/10.1002/psc.2497
https://doi.org/10.1002/psc.2497
Publikováno v:
Chem. Soc. Rev.. 41:1826-1844
The highly refined organic chemistry in solid-phase synthesis has made it the method of choice not only to assemble peptides but also small proteins - mainly on a laboratory scale but increasingly also on an industrial scale. While conductive heating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70704eef89c7c9ded880a204defd0efe
https://doi.org/10.1039/c1cs15214a
https://doi.org/10.1039/c1cs15214a
Autor:
Knud J. Jensen, Thomas Hoeg-Jensen, Jesper Nygaard, Leila Malik, Lise Arleth, Rasmus Høiberg-Nielsen
Publikováno v:
Langmuir. 28:593-603
The self-assembly of biopharmaceutical peptides into multimeric, nanoscale objects, as well as their disassembly to monomers, is central for their mode of action. Here, we describe a bioorthogonal strategy, using a non-native recognition principle, f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b66a670fe7961da3a883000fff80c4a
https://doi.org/10.1021/la203042c
https://doi.org/10.1021/la203042c
Publikováno v:
Journal of Peptide Science. 16:506-512
Precise microwave heating has emerged as a valuable method to aid solid-phase peptide synthesis (SPPS). New methods and reliable protocols, as well as their embodiment in automated instruments, are required to fully use this potential. Here we descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6b080e241769515fcea20e403899832
https://doi.org/10.1002/psc.1269
https://doi.org/10.1002/psc.1269
Autor:
Knud J. Jensen, Peter W. Thulstrup, Lise Arleth, Werner Streicher, Leila Malik, Birthe B. Kragelund, Jesper Nygaard, Heike I. Rösner, Charlotte Madsen, Rasmus Høiberg-Nielsen, Niels J. Cristensen
Publikováno v:
Chembiochem : a European journal of chemical biology. 16(13)
De novo design and chemical synthesis of proteins and of other artificial structures that mimic them is a central strategy for understanding protein folding and for accessing proteins with new functions. We have previously described carbohydrates tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec19ee004235bc75eaebdcd3a380c61
https://pubmed.ncbi.nlm.nih.gov/26147795
https://pubmed.ncbi.nlm.nih.gov/26147795
Autor:
Leila Malik, Knud J. Jensen
Publikováno v:
ChemInform. 46
Fast and precise heating by microwave irradiation during solid-phase peptide synthesis (SPPS) can reduce reaction times as well as provide better purities and greater yields for the synthesis of difficult peptides. Microwave- assisted SPPS has proven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c76fa1a84aa9db28c34660ab5406bebf
https://doi.org/10.1002/chin.201521279
https://doi.org/10.1002/chin.201521279
Autor:
Kenji C Nishihara, Klaus Albertshofer, Brett P. Monia, Eric E. Swayze, Martin Maier, Leila Malik, Andrew M. Siwkowski, C. Frank Bennett, Anne B. Eldrup, Edward Wancewicz, Garth A. Kinberger, Richard S. Geary, Christine Esau, Richard H. Griffey, Muthiah Manoharan, Tanya Watanabe
Publikováno v:
Journal of Medicinal Chemistry. 48:6741-6749
Improving cellular uptake and biodistribution remains one of the major obstacles for a successful and broad application of peptide nucleic acids (PNAs) as antisense therapeutics. Recently, we reported the identification and functional characterizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99435f07c1247e482294ae1976ff9413
https://doi.org/10.1021/jm050490b
https://doi.org/10.1021/jm050490b
Autor:
Steven S. Carroll, Sanjib Bera, David B. Olsen, Renee Hrin, Joanne E. Tomassini, Malcolm MacCoss, Daniel R. McMasters, Balkrishen Bhat, Michael D. Miller, Leila Malik, Anne B. Eldrup, William A. Schleif, Greg Moyer
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:6237-6247
1,3-Dioxolane and 1,3-oxathiolane nucleoside analogs play an important role in anti-viral and anti-neoplastic chemotherapy. We report here the synthesis of 2-hydroxymethyl-5-methyl-1,3-dioxolanylpurine nucleosides from 4-acetoxy-2-(benzyloxymethyl)-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238bab08e1dc51f83c063d82bcbbcfd9
https://doi.org/10.1016/j.bmc.2004.08.054
https://doi.org/10.1016/j.bmc.2004.08.054
Autor:
Brett P. Monia, Edward Wancewicz, Leila Malik, Martin Maier, Anne B. Eldrup, C. Frank Bennett, Christine Esau, Klaus Albertshofer, Andrew M. Siwkowski
Publikováno v:
Nucleic Acids Research. 32:2695-2706
Cognate recognition between the CD40 receptor and its ligand, CD154, is thought to play a central role in the initiation and propagation of immune responses. We describe the specific down regulation of cell surface associated CD40 protein expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00938a99b5d71f7fdaa4c0e1ab67d9eb
https://doi.org/10.1093/nar/gkh584
https://doi.org/10.1093/nar/gkh584