Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Leila, Gobejishvili"'
Autor:
Paula M. Chilton, Smita S. Ghare, Benjamin T. Charpentier, Scott A. Myers, Aakarsha V. Rao, Joseph F. Petrosino, Kristi L. Hoffman, John C. Greenwell, Neetu Tyagi, Jyotirmaya Behera, Yali Wang, Lucy J. Sloan, JingWen Zhang, Christopher B. Shields, Gregory E. Cooper, Leila Gobejishvili, Scott R. Whittemore, Craig J. McClain, Shirish S. Barve
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
Alterations in the gut-microbiome-brain axis are increasingly being recognized to be involved in Alzheimer’s disease (AD) pathogenesis. However, the functional consequences of enteric dysbiosis linking gut microbiota and brain pathology in AD progr
Externí odkaz:
https://doaj.org/article/68fececdccb84cc983088b9ee897f11c
Autor:
Mary Nancy Walter, Diego Montoya-Durango, Walter Rodriguez, Yali Wang, JingWen Zhang, Julia H. Chariker, Eric C. Rouchka, Claudio Maldonado, Anton Bennett, Craig James McClain, Shirish Barve, Leila Gobejishvili
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundIt is well established that females are more susceptible to the toxic effects of alcohol, although the exact mechanisms are still poorly understood. Previous studies noted that alcohol reduces the expression of mitogen-activated protein kin
Externí odkaz:
https://doaj.org/article/c2dc621737be44c5a622b0839e967c35
Autor:
Leila Gobejishvili, Vatsalya Vatsalya, Diana V. Avila, Yana B. Feygin, Craig J. McClain, Sriprakash Mokshagundam, Shirish Barve
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1227 (2024)
Background: Virtually the entire spectrum of liver disease is observed in association with type 2 diabetes mellitus (T2DM); indeed, T2DM is now the most common cause of liver disease in the U.S. We conducted a pilot study to investigate the relevance
Externí odkaz:
https://doaj.org/article/c61f484e543b4433bd2cec561bb67713
Autor:
Leila Gobejishvili
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/f703f006711c498e89b24297f1a80b87
Autor:
Diego Montoya-Durango, Mary Nancy Walter, Walter Rodriguez, Yali Wang, Julia H. Chariker, Eric C. Rouchka, Claudio Maldonado, Shirish Barve, Craig J. McClain, Leila Gobejishvili
Publikováno v:
Biology, Vol 12, Iss 10, p 1321 (2023)
Background: Cyclic nucleotides are second messengers, which play significant roles in numerous biological processes. Previous work has shown that cAMP and cGMP signaling regulates various pathways in liver cells, including Kupffer cells, hepatocytes,
Externí odkaz:
https://doaj.org/article/18569421050f4eb4885efe87cba9f9c4
Autor:
Hridgandh Donde, Smita Ghare, Swati Joshi-Barve, JingWen Zhang, Manicka V. Vadhanam, Leila Gobejishvili, Pawel Lorkiewicz, Sanjay Srivastava, Craig J. McClain, Shirish Barve
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 4, Pp 569-585 (2020)
Ethanol-mediated down-regulation of carnitine palmitoyltransferase-1 (CPT-1A) gene expression plays a major role in the development of hepatic steatosis; however, the underlying mechanisms are not completely elucidated. Tributyrin, a butyrate prodrug
Externí odkaz:
https://doaj.org/article/f3a042fee3bf4843a2824a67ecfa98b0
Autor:
Scott A. Myers, Leila Gobejishvili, Sujata Saraswat Ohri, C. Garrett Wilson, Kariena R. Andres, Amberly S. Riegler, Hridgandh Donde, Swati Joshi-Barve, Shirish Barve, Scott R. Whittemore
Publikováno v:
Neurobiology of Disease, Vol 124, Iss , Pp 353-363 (2019)
Emerging evidence links changes in the gut microbiome and intestinal barrier function to alterations in CNS function. We examined the role of endotoxin-responsive, cAMP-specific, Pde4 subfamily b (Pde4b) enzyme in gut dysbiosis induced neuro-inflamma
Externí odkaz:
https://doaj.org/article/5aac30fa5f7f4eeca98245bdc289a49d
Autor:
Richa Singhal, Hridgandh Donde, Smita Ghare, Kendall Stocke, Jingwein Zhang, Manicka Vadhanam, Sreelatha Reddy, Leila Gobejishvili, Paula Chilton, Swati Joshi-Barve, Wenke Feng, Craig McClain, Kristi Hoffman, Joseph Petrosino, Marius Vital, Shirish Barve
Publikováno v:
Gut Microbes, Vol 13, Iss 1 (2021)
Emerging research evidence has established the critical role of the gut-liver axis in the development of alcohol-associated liver disease (ALD). The present study employed 16S rRNA gene and whole genome shotgun (WGS) metagenomic analysis in combinati
Externí odkaz:
https://doaj.org/article/793e75a4ade442eb8e87286dac6041c2
Autor:
Dominique Z. Jones, M. Lee Schmidt, Suman Suman, Katharine R. Hobbing, Shirish S. Barve, Leila Gobejishvili, Guy Brock, Carolyn M. Klinge, Shesh N. Rai, Jong Park, Geoffrey J. Clark, Rajesh Agarwal, LaCreis R. Kidd
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-16 (2018)
Abstract Background Dysregulation of microRNA (miRNA) expression is associated with hallmarks of aggressive tumor phenotypes, e.g., enhanced cell growth, proliferation, invasion, and anchorage independent growth in prostate cancer (PCa). Methods Seru
Externí odkaz:
https://doaj.org/article/bfc4991aa79b45b7bd513dceb81c33ea
Autor:
Leila Gobejishvili, Walter E Rodriguez, Philip Bauer, Yali Wang, Chirag Soni, Todd Lydic, Shirish Barve, Craig McClain, Claudio Maldonado
Publikováno v:
Drug Design, Development and Therapy. 16:1301-1309
Leila Gobejishvili,1 Walter E Rodriguez,1 Philip Bauer,2 Yali Wang,1 Chirag Soni,2 Todd Lydic,3 Shirish Barve,1 Craig McClain,1 Claudio Maldonado4 1Department of Medicine, School of Medicine, University of Louisville, Louisville, KY, USA; 2Endoprotec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71458b66a22f770d02559f36a23e92f6
https://doi.org/10.2147/dddt.s355796
https://doi.org/10.2147/dddt.s355796