Výsledky vyhledávání - "Leijiane F. Sousa"

Akademický článek

Diversity of Phospholipases A2 from Bothrops atrox Snake Venom: Adaptive Advantages for Snakes Compromising Treatments for Snakebite Patients

Autor: Leijiane F. Sousa, Amanda P. Freitas, Bruna L. Cardoso, Tiago H. M. Del-Rei, Vanessa A. Mendes, Daniele P. Oréfice, Marisa M. T. Rocha, Benedito C. Prezoto, Ana M. Moura-da-Silva

Publikováno v: Toxins, Vol 14, Iss 8, p 543 (2022)

The evolution of snake venoms resulted in multigene toxin families that code for structurally similar isoforms eventually harboring distinct functions. PLA2s are dominant toxins in viper venoms, and little is known about the impact of their diversity

Externí odkaz: https://doaj.org/article/0503a86b0db448c2b3f4ddb153bde8f5

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Akademický článek

Coagulotoxicity of Bothrops (Lancehead Pit-Vipers) Venoms from Brazil: Differential Biochemistry and Antivenom Efficacy Resulting from Prey-Driven Venom Variation

Autor: Leijiane F. Sousa, Christina N. Zdenek, James S. Dobson, Bianca op den Brouw, Francisco C. P. Coimbra, Amber Gillett, Tiago H. M. Del-Rei, Hipócrates de M. Chalkidis, Sávio Sant’Anna, Marisa M. Teixeira-da-Rocha, Kathleen Grego, Silvia R. Travaglia Cardoso, Ana M. Moura da Silva, Bryan G. Fry

Publikováno v: Toxins, Vol 10, Iss 10, p 411 (2018)

Lancehead pit-vipers (Bothrops genus) are an extremely diverse and medically important group responsible for the greatest number of snakebite envenomations and deaths in South America. Bothrops atrox (common lancehead), responsible for majority of sn

Externí odkaz: https://doaj.org/article/ec065dbcb46d43d9b3acf7458af218be

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Functional variability of Bothrops atrox venoms from three distinct areas across the Brazilian Amazon and consequences for human envenomings

Autor: Tiago H. M. Del-Rei, Sávio Stefanini Sant'Anna, Kathleen Fernandes Grego, Ana Maria Moura-da-Silva, Hipócrates de Menezes Chalkidis, Silvia Regina Travaglia-Cardoso, Luciana A. Freitas-de-Sousa, Marisa Maria Teixeira da Rocha, Leijiane F. Sousa

Publikováno v: Toxicon. 164:61-70

Variability in the composition of snake venoms occurs in different taxa and is usually correlated to snake fitness. Here, we compared B. atrox venoms from three different geographic regions across the Brazilian Amazon and found remarkable functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d945f11383909a122c2505e7ab93dd
https://doi.org/10.1016/j.toxicon.2019.04.001

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Akademický článek

Functional variability of snake venom metalloproteinases: adaptive advantages in targeting different prey and implications for human envenomation.

Autor: Juliana L Bernardoni, Leijiane F Sousa, Luciana S Wermelinger, Aline S Lopes, Benedito C Prezoto, Solange M T Serrano, Russolina B Zingali, Ana M Moura-da-Silva

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e109651 (2014)

Snake venom metalloproteinases (SVMPs) are major components in most viperid venoms that induce disturbances in the hemostatic system and tissues of animals envenomated by snakes. These disturbances are involved in human pathology of snake bites and a

Externí odkaz: https://doaj.org/article/19e19f63d5534dd381636d6e49d4fa98

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Akademický článek

Comparison of phylogeny, venom composition and neutralization by antivenom in diverse species of bothrops complex.

Autor: Leijiane F Sousa, Carolina A Nicolau, Pedro S Peixoto, Juliana L Bernardoni, Sâmella S Oliveira, José Antonio Portes-Junior, Rosa Helena V Mourão, Isa Lima-dos-Santos, Ida S Sano-Martins, Hipócrates M Chalkidis, Richard H Valente, Ana M Moura-da-Silva

Publikováno v: PLoS Neglected Tropical Diseases, Vol 7, Iss 9, p e2442 (2013)

In Latin America, Bothrops snakes account for most snake bites in humans, and the recommended treatment is administration of multispecific Bothrops antivenom (SAB--soro antibotrópico). However, Bothrops snakes are very diverse with regard to their v

Externí odkaz: https://doaj.org/article/c881e9b5ad7b4cecba8796c5c078211c

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Differential coagulotoxicity of metalloprotease isoforms from Bothrops neuwiedi snake venom and consequent variations in antivenom efficacy

Autor: Ana Maria Moura-da-Silva, Mônica Lopes-Ferreira, Juliana L. Bernardoni, Leijiane F. Sousa, Francisco C. P. Coimbra, Christina N. Zdenek, Bryan G. Fry, Amber Gillett, James Dobson

Publikováno v: Toxicology letters. 333

Bothrops (lance-head pit vipers) venoms are rich in weaponised metalloprotease enzymes (SVMP). These toxic enzymes are structurally diverse and functionally versatile. Potent coagulotoxicity is particularly important for prey capture (via stroke-indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4acc9e59d02d62c453c990cee795a277
https://pubmed.ncbi.nlm.nih.gov/32841740

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Pets in peril: The relative susceptibility of cats and dogs to procoagulant snake venoms

Autor: Ana Maria Moura da Silva, Luke Allen, Bryan G. Fry, Joshua Llinas, Christina N. Zdenek, Leijiane F. Sousa, Nathan Dunstan, James Dobson

Publikováno v: Comparative biochemistry and physiology. Toxicologypharmacology : CBP. 236

Snakebite is a common occurrence for pet cats and dogs worldwide and can be fatal. In Australia the eastern brown snake (Pseudonaja textilis) is responsible for an estimated 76% of reported snakebite cases to domestic pets nationally each year, with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af856db858f518c7fa1bc038170bf84d
https://pubmed.ncbi.nlm.nih.gov/32376497

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Functional proteomic analyses of Bothrops atrox venom reveals phenotypes associated with habitat variation in the Amazon

Autor: Ana Maria Moura-da-Silva, Milton Y. Nishiyama, Carolina A. Nicolau, José Antonio Portes-Junior, Richard H. Valente, Hipócrates de Menezes Chalkidis, Leijiane F. Sousa, Juliana L. Bernardoni, Diana R. Amazonas, Rosa Helena Veras Mourão, Luciana A. Freitas-de-Sousa

Publikováno v: Journal of Proteomics. 159:32-46

Venom variability is commonly reported for venomous snakes including Bothrops atrox. Here, we compared the composition of venoms from B. atrox snakes collected at Amazonian conserved habitats (terra-firme upland forest and varzea) and human modified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f4458bbcd925ec782a7c4db7a81be0
https://doi.org/10.1016/j.jprot.2017.03.003

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