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pro vyhledávání: '"Leigh-Brown A"'
Autor:
Steven Weaver, Vanessa M. Dávila Conn, Daniel Ji, Hannah Verdonk, Santiago Ávila-Ríos, Andrew J. Leigh Brown, Joel O. Wertheim, Sergei L. Kosakovsky Pond
Publikováno v:
Frontiers in Bioinformatics, Vol 4 (2024)
Molecular surveillance of viral pathogens and inference of transmission networks from genomic data play an increasingly important role in public health efforts, especially for HIV-1. For many methods, the genetic distance threshold used to connect se
Externí odkaz:
https://doaj.org/article/4224de6e5bd44b569093ce7fd9f1f999
Akademický článek
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Autor:
Dellagrammaticas Demosthenes, Torgerson David, Gough Moira, Banning Adrian P, Rothwell Peter M, Lewis Steff C, Colam Bridget, Horrocks Michael, Bodenham Andrew, Gough Michael J, Leigh-Brown Anne, Liapis Christos, Warlow Charles
Publikováno v:
Trials, Vol 9, Iss 1, p 28 (2008)
Abstract Background Patients who have severe narrowing at or near the origin of the internal carotid artery as a result of atherosclerosis have a high risk of ischaemic stroke ipsilateral to the arterial lesion. Previous trials have shown that caroti
Externí odkaz:
https://doaj.org/article/b96f512a1b0b48ff994258f6db41d30c
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-9 (2023)
Abstract TDP-43 is an RNA-binding protein with a crucial nuclear role in splicing, and mislocalises from the nucleus to the cytoplasm in a range of neurodegenerative disorders. TDP-43 proteinopathy spans a spectrum of incurable, heterogeneous, and in
Externí odkaz:
https://doaj.org/article/c2741b5e80194d549e3f338eb6ddeb60
Publikováno v:
BMC Health Services Research, Vol 2, Iss 1, p 2 (2002)
Abstract Background Economic evaluations alongside clinical trials are becoming increasingly common. Cost data are often collected through the use of postal questionnaires; however, the accuracy of this method is uncertain. We compared postal questio
Externí odkaz:
https://doaj.org/article/b163c59756374359bf5a71b5f6ccdb9c
Autor:
Baxter, James *, Langhorne, Sarah, Shi, Ting, Tully, Damien C, Villabona-Arenas, Ch Julián, Hué, Stéphane, Albert, Jan, Leigh Brown, Andrew, Atkins, Katherine E
Publikováno v:
In The Lancet Microbe February 2023 4(2):e102-e112
Autor:
Heather E. Grant, Sunando Roy, Rachel Williams, Helena Tutill, Bridget Ferns, Patricia A. Cane, J. Wilson Carswell, Deogratius Ssemwanga, Pontiano Kaleebu, Judith Breuer, Andrew J. Leigh Brown
Publikováno v:
Retrovirology, Vol 19, Iss 1, Pp 1-10 (2022)
Abstract We present 109 near full-length HIV genomes amplified from blood serum samples obtained during early 1986 from across Uganda, which to our knowledge is the earliest and largest population sample from the initial phase of the HIV epidemic in
Externí odkaz:
https://doaj.org/article/b9ce012fa63f4886844455303bb654f5
Autor:
Urša Šušnjar, Neva Škrabar, Anna-Leigh Brown, Yasmine Abbassi, Hemali Phatnani, NYGC ALS Consortium, Andrea Cortese, Cristina Cereda, Enrico Bugiardini, Rosanna Cardani, Giovanni Meola, Michela Ripolone, Maurizio Moggio, Maurizio Romano, Maria Secrier, Pietro Fratta, Emanuele Buratti
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
The aetiology of the TDP-43 aggregation manifest itself in the muscle and neuronal cells. Here authors show cell-type characteristic functions of TDP43, reflected in aberrant splicing, likely contributing to disease development.
Externí odkaz:
https://doaj.org/article/a2a3e5c080324289af930097b013f70e
Autor:
Hassan W. Kayondo, Alfred Ssekagiri, Grace Nabakooza, Nicholas Bbosa, Deogratius Ssemwanga, Pontiano Kaleebu, Samuel Mwalili, John M. Mango, Andrew J. Leigh Brown, Roberto A. Saenz, Ronald Galiwango, John M. Kitayimbwa
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-20 (2021)
Abstract Background Host population structure is a key determinant of pathogen and infectious disease transmission patterns. Pathogen phylogenetic trees are useful tools to reveal the population structure underlying an epidemic. Determining whether a
Externí odkaz:
https://doaj.org/article/f921303b4ec8402c97778b1b59c8ee53
Autor:
Nitin Roper, Moises J. Velez, Alberto Chiappori, Yoo Sun Kim, Jun S. Wei, Sivasish Sindiri, Nobuyuki Takahashi, Deborah Mulford, Suresh Kumar, Kris Ylaya, Christopher Trindade, Irena Manukyan, Anna-Leigh Brown, Jane B. Trepel, Jung-Min Lee, Stephen Hewitt, Javed Khan, Anish Thomas
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Immune checkpoint blockade (ICB) benefits only a small subset of patients with small cell lung cancer (SCLC) and the mechanisms driving benefit are poorly understood. Here, the authors show that elevated Notch signaling predicts clinical benefit in I
Externí odkaz:
https://doaj.org/article/14cd7395b4e240a6a4c5e9753ff63101