Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Leigh Nicholson"'
1
Akademický článek
Standardisation of flow cytometry for whole blood immunophenotyping of islet transplant and transplant clinical trial recipients.
Autor: Elvira Jimenez Vera, Yi Vee Chew, Leigh Nicholson, Heather Burns, Patricia Anderson, Hsiao-Ting Chen, Lindy Williams, Karen Keung, Negar Talaei Zanjani, Suat Dervish, Ellis Patrick, Xin Maggie Wang, Shounan Yi, Wayne Hawthorne, Stephen Alexander, Philip J O'Connell, Min Hu
Publikováno v: PLoS ONE, Vol 14, Iss 5, p e0217163 (2019)
Understanding the immunological phenotype of transplant recipients is important to improve outcomes and develop new therapies. Immunophenotyping of whole peripheral blood (WPB) by flow cytometry is a rapid method to obtain large amounts of data relat
Externí odkaz: https://doaj.org/article/a1e416a56f2c4bc2993941ecd793b207
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2
Post‐transplant cyclophosphamide limits reactive donor T cells and delays the development of graft‐versus‐host disease in a humanized mouse model
Autor: Katrina M. Bird, Sam R. Adhikary, Leigh Nicholson, Ronald Sluyter, Peter Cuthbertson, Chloe Sligar, Philip J. O'Connell, Stephen I. Alexander, Min Hu, Debbie Watson
Publikováno v: Immunology
Graft‐versus‐host disease (GVHD) is a major complication of allogeneic haematopoietic stem cell transplantation (allo‐HSCT) that develops when donor T cells in the graft become reactive against the host. Post‐transplant cyclophosphamide (PTCy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74b8e74538fe7e6ab91745857646a63
https://doi.org/10.1111/imm.13374
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3
Low-Dose Interleukin-2 Combined With Rapamycin Led to an Expansion of CD4+CD25+FOXP3+ Regulatory T Cells and Prolonged Human Islet Allograft Survival in Humanized Mice
Autor: Karen Keung, Yi Vee Chew, Yi Wen Qian, Philip J. O'Connell, Wayne J. Hawthorne, Shounan Yi, Debbie Watson, Natasha M. Rogers, Lindy Williams, Stephen I. Alexander, David Liuwantara, Min Hu, Heather Burns, Leigh Nicholson, Elvira Jimenez Vera
Publikováno v: Diabetes. 69:1735-1748
Islet transplantation is an emerging therapy for type 1 diabetes and hypoglycemic unawareness. However, a key challenge for islet transplantation is cellular rejection and the requirement for long-term immunosuppression. In this study, we established
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::509ef85afda9ec5108ccd030c2de2b58
https://doi.org/10.2337/db19-0525
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4
Advanced molecular pathology for rare tumours: a national feasibility study and model for centralised medulloblastoma diagnostics
Autor: Janet C. Lindsey, Edward C. Schwalbe, Stephen Crosier, Nick Bown, Sarah Leigh Nicholson, Barry Pizer, Daniel Williamson, Amanda Smith, Simon Bailey, Steven C. Clifford, Abhijit Joshi, Thomas S. Jacques, Debbie Hicks, Antony Michalski, Stephen B. Wharton, Gavin Cuthbert
Publikováno v: Neuropathology and Applied Neurobiology
Aims Application of advanced molecular pathology in rare tumours is hindered by low sample numbers, access to specialised expertise/technologies and tissue/assay QC and rapid reporting requirements. We assessed the feasibility of co‐ordinated real
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41858bc08691790bb15c3655b2645fab
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6
Key driver genes as potential therapeutic targets in renal allograft rejection
Autor: Li Li, Karen L. Keung, Leigh Nicholson, Madhav C. Menon, Min Hu, Elvira Jimenez-Vera, Stephen I. Alexander, Barbara Murphy, Weijia Zhang, Philip J. O'Connell, Zhengzi Yi, Chengguo Wei, Bo Lu
Publikováno v: JCI Insight
Acute rejection (AR) in renal transplantation is an established risk factor for reduced allograft survival. Molecules with regulatory control among immune pathways of AR that are inadequately suppressed, despite standard-of-care immunosuppression, co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e22229535756641ccc5ae638deca615b
https://doi.org/10.1172/jci.insight.136220
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7
Akademický článek
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8
Low-Dose Interleukin-2 Combined With Rapamycin Led to an Expansion of CD4
Autor: Min, Hu, Wayne J, Hawthorne, Leigh, Nicholson, Heather, Burns, Yi Wen, Qian, David, Liuwantara, Elvira, Jimenez Vera, Yi Vee, Chew, Lindy, Williams, Shounan, Yi, Karen, Keung, Debbie, Watson, Natasha, Rogers, Stephen I, Alexander, Philip J, O'Connell
Publikováno v: Diabetes. 69(8)
Islet transplantation is an emerging therapy for type 1 diabetes and hypoglycemic unawareness. However, a key challenge for islet transplantation is cellular rejection and the requirement for long-term immunosuppression. In this study, we established
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::808f9acc8e502bd270c57f91f878f158
https://pubmed.ncbi.nlm.nih.gov/32381646
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9
Standardisation of flow cytometry for whole blood immunophenotyping of islet transplant and transplant clinical trial recipients
Autor: Yi Vee Chew, Xin Maggie Wang, Shounan Yi, Lindy Williams, Stephen I. Alexander, Karen Keung, Heather Burns, Patricia Anderson, Wayne J. Hawthorne, Negar Talaei Zanjani, Leigh Nicholson, Min Hu, Elvira Jimenez Vera, Ellis Patrick, Hsiao-Ting Chen, Philip J. O'Connell, Suat Dervish
Publikováno v: PLoS ONE
PLoS ONE, Vol 14, Iss 5, p e0217163 (2019)
Understanding the immunological phenotype of transplant recipients is important to improve outcomes and develop new therapies. Immunophenotyping of whole peripheral blood (WPB) by flow cytometry is a rapid method to obtain large amounts of data relat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e8bff75112b7e526bc3b577883a259
https://pubmed.ncbi.nlm.nih.gov/31116766
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