Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Leigh M. Marsh"'
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 16 (2023)
The pulmonary vasculature has been frequently overlooked in acute and chronic lung diseases, such as acute respiratory distress syndrome (ARDS), pulmonary fibrosis (PF), and chronic obstructive pulmonary disease (COPD). The primary emphasis in the ma
Externí odkaz:
https://doaj.org/article/9f86419b4baa4a8a9a38e9a7a3558ac3
Autor:
Slaven Crnkovic, Francesco Valzano, Elisabeth Fließer, Jürgen Gindlhuber, Helene Thekkekara Puthenparampil, Maria Basil, Mike P. Morley, Jeremy Katzen, Elisabeth Gschwandtner, Walter Klepetko, Edward Cantu, Heimo Wolinski, Horst Olschewski, Jörg Lindenmann, You-Yang Zhao, Edward E. Morrisey, Leigh M. Marsh, Grazyna Kwapiszewska
Publikováno v:
JCI Insight, Vol 7, Iss 20 (2022)
A central feature of progressive vascular remodeling is altered smooth muscle cell (SMC) homeostasis; however, the understanding of how different cell populations contribute to this process is limited. Here, we utilized single-cell RNA sequencing to
Externí odkaz:
https://doaj.org/article/44b0a9ebfeff415b9c53d340fe872d68
Autor:
Martin Zacharias, Karl Kashofer, Philipp Wurm, Peter Regitnig, Moritz Schütte, Margit Neger, Sandra Ehmann, Leigh M. Marsh, Grazyna Kwapiszewska, Martina Loibner, Anna Birnhuber, Eva Leitner, Andrea Thüringer, Elke Winter, Stefan Sauer, Marion J. Pollheimer, Fotini R. Vagena, Carolin Lackner, Barbara Jelusic, Lesley Ogilvie, Marija Durdevic, Bernd Timmermann, Hans Lehrach, Kurt Zatloukal, Gregor Gorkiewicz
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104926- (2022)
Summary: Secondary infections contribute significantly to covid-19 mortality but driving factors remain poorly understood. Autopsies of 20 covid-19 cases and 14 controls from the first pandemic wave complemented with microbial cultivation and RNA-seq
Externí odkaz:
https://doaj.org/article/3b9ab54a489a475a9778db17045793d4
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Natural killer (NK) cells play an important role in recognizing and killing pathogen-infected or malignant cells. Changes in their numbers or activation can contribute to several diseases and pathologies including systemic sclerosis (SSc), an autoimm
Externí odkaz:
https://doaj.org/article/3141d0b45b80470da533df5c6780bf7b
Autor:
Anna Birnhuber, Bakytbek Egemnazarov, Valentina Biasin, Ehsan Bonyadi Rad, Malgorzata Wygrecka, Horst Olschewski, Grazyna Kwapiszewska, Leigh M. Marsh
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-5 (2020)
Abstract Inhibitors of cyclin-dependent kinases 4/6 (CDK4/6) block cell cycle progression and are commonly used for treatment of several forms of cancer. Due to their anti-proliferative mode of action, we hypothesized that palbociclib could attenuate
Externí odkaz:
https://doaj.org/article/0a27b65be7534d0e94a7a82613d56f71
Autor:
Natalie Bordag, Valentina Biasin, Diana Schnoegl, Francesco Valzano, Katharina Jandl, Bence M. Nagy, Neha Sharma, Malgorzata Wygrecka, Grazyna Kwapiszewska, Leigh M. Marsh
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101819- (2020)
Summary: The bleomycin mouse model is the extensively used model to study pulmonary fibrosis; however, the inflammatory cell kinetics and their compartmentalization is still incompletely understood. Here we assembled historical flow cytometry data, t
Externí odkaz:
https://doaj.org/article/49deb8957ed3459c966b0f361a4ecc99
Autor:
Anna Gungl, Valentina Biasin, Jochen Wilhelm, Andrea Olschewski, Grazyna Kwapiszewska, Leigh M. Marsh
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Background: Asthma is a complex chronic inflammatory disease characterised by airway inflammation, remodelling and hyperresponsiveness (AHR). Members of the AP-1 transcription factor family play important roles in the activation of the immune system
Externí odkaz:
https://doaj.org/article/aa5dc9818d2c426f8b76b282d334be5d
Autor:
Csilla Fazakas, Chandran Nagaraj, Diana Zabini, Attila G. Végh, Leigh M. Marsh, Imola Wilhelm, István A. Krizbai, Horst Olschewski, Andrea Olschewski, Zoltán Bálint
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
The multi-kinase inhibitor dasatinib is used for treatment of imatinib-resistant chronic myeloid leukemia, but is prone to induce microvascular dysfunction. In lung this can manifest as capillary leakage with pleural effusion, pulmonary edema or even
Externí odkaz:
https://doaj.org/article/1e345bf8670542e8ba1aea20eb0a6393
Autor:
Katharina Jandl, Leigh M. Marsh, Ayse Ceren Mutgan, Slaven Crnkovic, Francesco Valzano, Diana Zabini, Julia Hoffmann, Vasile Foris, Elisabeth Gschwandtner, Walter Klepetko, Helmut Prosch, Holger Flick, Luka Brcic, Izidor Kern, Akos Heinemann, Horst Olschewski, Gabor Kovacs, Grazyna Kwapiszewska
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 207:796-798
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f23d86b5acf99b0f44ab75e60b50a68d
https://doi.org/10.1164/rccm.202212-2214le
https://doi.org/10.1164/rccm.202212-2214le
Autor:
Slaven Crnkovic, Sonja Rittchen, Katharina Jandl, Juergen Gindlhuber, Diana Zabini, Ayse Ceren Mutgan, Francesco Valzano, Panja M. Boehm, Konrad Hoetzenecker, Wolfgang Toller, Christine Veith, Akos Heinemann, Ralph T. Schermuly, Andrea Olschewski, Leigh M. Marsh, Grazyna Kwapiszewska
Publikováno v:
Hypertension. 80
Background: Smooth muscle cell (SMC) expansion is one key morphological hallmark of pathologically altered vasculature and a characteristic feature of pulmonary vascular remodeling in pulmonary hypertension. Normal embryonal vessel maturation require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5998efa6b0063822899ca403dfc2f806
https://doi.org/10.1161/hypertensionaha.122.19479
https://doi.org/10.1161/hypertensionaha.122.19479