CCL2-Mediated Stromal Interactions Drive Macrophage Polarization to Increase Breast Tumorigenesis

Autor: Maddison Archer, Sarah M. Bernhardt, Leigh J. Hodson, Lucy Woolford, Mark Van der Hoek, Pallave Dasari, Andreas Evdokiou, Wendy V. Ingman

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7385

CCL2 is an inflammatory cytokine that regulates macrophage activity and is implicated in increased mammographic density and early breast tumorigenesis. The role of CCL2 in mediating stromal interactions that contribute to breast tumorigenesis has yet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304251ff74fd64bbd3ad1713c45c95da

Foxp3 heterozygosity does not overtly affect mammary gland development during puberty or the oestrous cycle in mice

Autor: Andreas Evdokiou, Wendy V. Ingman, Leigh J. Hodson, Vahid Atashgaran, Pallave Dasari, Simon C. Barry

Publikováno v: Reproduction, fertility, and development. 32(8)

Female mice heterozygous for a genetic mutation in transcription factor forkhead box p3 (Foxp3) spontaneously develop mammary cancers; however, the underlying mechanism is not well understood. We hypothesised that increased cancer susceptibility is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5542336925e787c6f278f8d7422016c6
https://pubmed.ncbi.nlm.nih.gov/32389178

Hormonal regulation of the cytokine microenvironment in the mammary gland

Autor: Pallave Dasari, David J. Sharkey, Effarina Noordin, Danielle J. Glynn, Leigh J. Hodson, Peck Y. Chin, Andreas Evdokiou, Sarah A. Robertson, Wendy V. Ingman

Publikováno v: Journal of reproductive immunology. 106

The mammary gland is a unique organ that undergoes hormone-driven developmental changes over the course of the ovarian cycle during adult life. Macrophages play a role in regulating cellular turnover in the mammary gland and may affect cancer suscept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797f06b7d6845185e4a68e2191f9cf90
https://pubmed.ncbi.nlm.nih.gov/25138705

Dual roles for macrophages in ovarian cycle-associated development and remodelling of the mammary gland epithelium

Autor: Leigh J. Hodson, Sarah A. Robertson, Angela C.L. Chua, Wendy V. Ingman, Lachlan M. Moldenhauer

Publikováno v: Development (Cambridge, England). 137(24)

Each ovarian cycle, the mammary gland epithelium rotates through a sequence of hormonally regulated cell proliferation, differentiation and apoptosis. These studies investigate the role of macrophages in this cellular turnover. Macrophage populations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc9d11f00bcbe18b514e068f9c842e1
https://pubmed.ncbi.nlm.nih.gov/21068060

CCL2-driven inflammation increases mammary gland stromal density and cancer susceptibility in a transgenic mouse model

Autor: Andreas Evdokiou, Xuan Sun, Danielle J. Glynn, Wendy V. Ingman, Leigh J. Hodson, Cecilia Huo, Kara L. Britt, Lucy Woolford, Sarah A. Robertson, Erik W. Thompson, Jeffrey W. Pollard

Publikováno v: Breast Cancer Research : BCR
Sun, X, Glynn, D J, Hodson, L J, Huo, C, Britt, K, Thompson, E, Evdokiou, A, Pollard, J, Robertson, S A & Ingman, W V 2017, ' CCL2-driven inflammation increases mammary gland stromal density and cancer susceptibility in a transgenic mouse model. ', Breast Cancer Research . https://doi.org/10.1186/s13058-016-0796-z

Background Macrophages play diverse roles in mammary gland development and breast cancer. CC-chemokine ligand 2 (CCL2) is an inflammatory cytokine that recruits macrophages to sites of injury. Although CCL2 has been detected in human and mouse mammar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562200fcefefd211b13b3d75f528099a