Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Leigh Ford"'
Autor:
Erin Tay, Tri-Hung Nguyen, Leigh Ford, Hywel D. Williams, Hassan Benameur, Peter J. Scammells, Christopher J. H. Porter
Publikováno v:
Pharmaceutics, Vol 12, Iss 1, p 17 (2019)
Lipid based formulations (LBFs) are commonly employed to enhance the absorption of highly lipophilic, poorly water-soluble drugs. However, the utility of LBFs can be limited by low drug solubility in the formulation. Isolation of ionizable drugs as l
Externí odkaz:
https://doaj.org/article/074cf2e8c38941079d00125509fd46b4
Autor:
Marisa N. Spann, Jessica L. Wisnowski, Christopher D. Smyser, Brittany Howell, Douglas C. Dean, Banu Ahtam, Wei Gao, Hao Huang, Mary Beth Nebel, Elizabeth S. Norton, Minhui Ouyang, Vidya Rajagopalan, Tracy Riggins, Zeynep M. Saygin, Lisa Scott, Moriah E. Thomason, Lauren S. Wakschlag, Sahar Ahmad, Ezra Aydin, A. James Barkovich, Evelyn Berger-Jenkins, Johanna Brick, Lindsay C. Bowman, M. Catalina Camacho, Claudia Lugo-Candelas, Rhodri Cusack, Jessica DuBois, Alexander J. Dufford, Jed T. Elison, Cameron T. Ellis, Silvina L. Ferradal, Courtney Filippi, Aiden Leigh Ford, Mahshid Fouladivanda, Nadine Gaab, Dawn Gano, Melanie Ganz-Benjaminsen, Simona Ghetti, Orit Ariel Glenn, Maria Jose Castro Gomez, Alice Graham, Cassandra L. Hendrix, Cristin M. Holland, Kathryn Humphreys, Marta Korom, Heather L. Kosakowski, Gang Li, Angela Gigliotti Manessis, Saara Nolvi, Roberta Pineda, Angeliki Pollatou, Caroline Rae, Jerod M. Rasmussen, Dustin Scheinost, Sara Shultz, Cristina Simon-Martinez, Kathrine Skak Madsen, Sooyeon Sung, Chad M. Sylvester, Ted K. Turesky, Kelly A. Vaughn, Lauren Wagner, Li Wang, Fleur L. Warton, Sylia Wilson, Pia Wintermark, Ye Wu, Pew-Thian Yap, Tristan S. Yates, Elizabeth Yen, Xi Yu, Hongtu Zhu, Lilla Zöllei
Publikováno v:
Biol Psychiatry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f790365eee46363fac600a485cd60e
https://doi.org/10.1016/j.biopsych.2022.09.025
https://doi.org/10.1016/j.biopsych.2022.09.025
Autor:
Colin W. Pouton, Shadabul Haque, Endri Kastrati, Vincent Jannin, Mitchell P. McInerney, David K. Chalmers, Karen M. Corbett, Christopher J.H. Porter, Leigh Ford, Hassan Benameur, Hywel David Williams, Dallas B. Warren
Publikováno v:
Pharmaceutical Research. 38:1531-1547
Molecular dynamics (MD) simulations provide an in silico method to study the structure of lipid-based formulations (LBFs) and the incorporation of poorly water-soluble drugs within such formulations. In order to validate the ability of MD to effectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0808af6cfd8a6e523d490d015ec480b6
https://doi.org/10.1007/s11095-021-03099-5
https://doi.org/10.1007/s11095-021-03099-5
Autor:
Philip E. Thompson, Hywel David Williams, Peter J. Scammells, Shadabul Haque, Mitchell P. McInerney, Peng Li, Hassan Benameur, Vincent Jannin, Christopher J.H. Porter, Colin W. Pouton, Leigh Ford
Publikováno v:
Pharmaceutical Research. 38:1125-1137
Successful oral peptide delivery faces two major hurdles: low enzymatic stability in the gastro-intestinal lumen and poor intestinal membrane permeability. While lipid-based formulations (LBF) have the potential to overcome these barriers, effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b12d9de7c2a9f94d3ad127d5c492292
https://doi.org/10.1007/s11095-021-03063-3
https://doi.org/10.1007/s11095-021-03063-3
Autor:
Anthony Lai, Nathania Leong, Dan Zheng, Leigh Ford, Tri-Hung Nguyen, Hywel D. Williams, Hassan Benameur, Peter J. Scammells, Christopher J. H. Porter
Publikováno v:
Pharmaceutical research. 39(10)
Purpose The use of ionic liquids (ILs) in drug delivery has focused attention on non-toxic IL counterions. Cationic lipids can be used to form ILs with weakly acidic drugs to enhance drug loading in lipid-based formulations (LBFs). However, cationic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ae245050bd09dece5c257e8b4eb275
https://pubmed.ncbi.nlm.nih.gov/35661084
https://pubmed.ncbi.nlm.nih.gov/35661084
Autor:
Colin W. Pouton, Amali G. Guruge, David K. Chalmers, Dallas B. Warren, Hywel David Williams, Vincent Jannin, Hassan Benameur, Leigh Ford
Publikováno v:
Molecular pharmaceutics. 18(12)
Type III lipid-based formulations (LBFs) combine poorly water-soluble drugs with oils, surfactants, and cosolvents to deliver the drugs into the systemic circulation. However, the solubility of the drug can be influenced by the colloidal phases forme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e60a711d2e0f31d059c5a5f6fd9dd26
https://pubmed.ncbi.nlm.nih.gov/34807627
https://pubmed.ncbi.nlm.nih.gov/34807627
Publikováno v:
Journal of medicinal chemistry. 64(18)
Cyclosporins are natural or synthetic undecapeptides with a wide range of actual and potential pharmaceutical applications. Several members of the cyclosporin compound family have remarkably high passive membrane permeabilities that are not well-desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d71ab3c3db68db699eb6d1a2c44cf9
https://pubmed.ncbi.nlm.nih.gov/34478303
https://pubmed.ncbi.nlm.nih.gov/34478303
Autor:
Guixian Hu, Annabel Igonin, Leigh Ford, Peter J. Scammells, Paolo Botti, Hywel David Williams, Zhenhua Shan, Michael M. Morgen, Hassan Benameur, Christopher J.H. Porter, Colin W. Pouton
Publikováno v:
Advanced Drug Delivery Reviews. 142:75-90
Lipid-based formulations (LBF) are widely used by industry and accepted by the regulatory authorities for oral drug delivery in the pharmaceutical and consumer healthcare market. Innovation in the LBF field is however needed in order to meet the dema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07125d6941f0a73eeb79b839bd7ae3ef
https://doi.org/10.1016/j.addr.2019.05.008
https://doi.org/10.1016/j.addr.2019.05.008
Autor:
Hassan Benameur, Christopher J.H. Porter, Leigh Ford, Erin Tay, Hywel David Williams, Peter J. Scammells, Tri-Hung Nguyen
Publikováno v:
RSC advances. 10(22)
Lipid based formulations (LBFs) are extensively utilised as an enabling technology in drug delivery. The use of ionic liquids (ILs) or lipophilic salts (LS) in drug delivery has also garnered considerable interest due to unique solubility properties.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd891cc97a080e235355429a65bcaf7
https://pubmed.ncbi.nlm.nih.gov/35492138
https://pubmed.ncbi.nlm.nih.gov/35492138
Autor:
Hassan Benameur, Tri-Hung Nguyen, Christopher J.H. Porter, Hywel David Williams, Leigh Ford, Erin Tay, Peter J. Scammells
Publikováno v:
Pharmaceutics, Vol 12, Iss 1, p 17 (2019)
Pharmaceutics
Volume 12
Issue 1
Pharmaceutics
Volume 12
Issue 1
Lipid based formulations (LBFs) are commonly employed to enhance the absorption of highly lipophilic, poorly water-soluble drugs. However, the utility of LBFs can be limited by low drug solubility in the formulation. Isolation of ionizable drugs as l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f69643d2ca0c13d2f9cc43d1412fe4f
https://www.mdpi.com/1999-4923/12/1/17
https://www.mdpi.com/1999-4923/12/1/17