C2-Symmetric Amino Acid Amide-Derived Organocatalysts

Autor: Zahraa S. Al-Taie, Simon J. Coles, Aileen Congreve, Dylan Ford, Lucy Green, Peter N. Horton, Leigh F. Jones, Pippa Kett, Rolf Kraehenbuehl, Patrick J. Murphy, Graham J. Tizzard, Niles B. Willmore, Oliver T. Wright

Publikováno v: Reactions, Vol 5, Iss 3, Pp 567-586 (2024)

N-alkylated C2-symmetric amino acid amide derivatives were shown to catalyse the Michael addition of 2-hydroxy-1,4-napthoquinone to β-nitrostyrene, achieving a maximum ee of 44%. The corresponding trifluoroacetic acid salts also catalysed the aldol

Externí odkaz: https://doaj.org/article/2e058adf8e1e4961b8135f679ae6da19

Cyclic guanidine containing amino acids that promote glucocerebrosidase

Autor: Zahraa S. Al-Taie, Barbara Bartholomew, Simon J. Coles, Daniel M. Evans, Jackie Hollinshead, Leigh F. Jones, Rolf Kraehenbuehl, Patrick J. Murphy, Robert J. Nash, Yana B. Penkova, Graham J. Tizzard

Publikováno v: Tetrahedron. 123:132959

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ae8825247718ad47f611b3c884876d
https://doi.org/10.1016/j.tet.2022.132959

N-carbamate protected amino acid derived guanidine organocatalysts

Autor: Richard Froom, Patrick J. Murphy, Laura Bischoff, Mari E. Gibbard, Leigh F. Jones, Frank F. J. de Kleijne, Joseph M. Anderson, Emma C. Thompson, Simon J. Coles, Jeppe Christensen, Zahraa S. Al-Taie

Publikováno v: Tetrahedron. 89:132093

We report the preparation of a range of N-protected amino acid derived guanidine organocatalysts and their application to the Michael addition of 2-hydroxy-1,4-napthoquinone to β-nitrostyrene, achieving a maximum ee of 26%. Whilst these catalysts ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c140b899cdd9cba653ec1e15f514f4c
https://doi.org/10.1016/j.tet.2021.132093

Elucidating cylindrospermopsin toxicity via synthetic analogues: An in vitro approach

Autor: Oksana Horyn, Piotr Rzymski, Inna M. Sokolova, Simon J. Coles, Leigh F. Jones, Jeppe Christensen, Patrick J. Murphy, Daniel M. Evans, J.C. Hughes, Halina Falfushynska

Publikováno v: Chemosphere. 234

Cylindrospermopsin (CYN) is an alkaloid biosynthesized by selected cyanobacteria, the cyto- and genotoxic properties of which have been studied extensively by in vitro and in vivo experimental models. Various studies have separately established the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7768ea0a9cb9b3eb710af336fb78d7e7
https://pubmed.ncbi.nlm.nih.gov/31207420

Crowding out: ligand modifications and their structure directing effects on brucite-like {M x (μ 3 -OH) y } (M = Co( ii ), Ni( ii )) core growth within polymetallic cages

Autor: Leigh F. Jones, Helen M. O'Connor, Mateusz B. Pitak, Mari E. Slater-Parry, Anne-Laure Barra, Wim T. Klooster, Simon J. Coles, Joshua M. Howells, James P. Durrant, Peter N. Horton, Euan K. Brechin

Publikováno v: Dalton Transactions
Dalton Transactions, Royal Society of Chemistry, 2019, 48 (4), pp.1477-1488. ⟨10.1039/c8dt04229b⟩
Slater-Parry, M E, Durrant, J P, Howells, J M, Pitak, M B, Horton, P N, Klooster, W T, Coles, S J, O'Connor, H M, Brechin, E K, Barra, A-L & Jones, L F 2019, ' Crowding out : ligand modifications and their structure directing effects on brucite-like {M-x((3)-OH)(y)} (M = Co(ii), Ni(ii)) core growth within polymetallic cages ', Dalton Transactions, vol. 48, no. 4, pp. 1477-1488 . https://doi.org/10.1039/C8DT04229B

International audience; Previous employment of the ligands 2-methoxy-6-[(methylimino)methyl]phenol (L1H) and 2-methoxy-6-[(phenylimino)methyl]phenol (L2H) has resulted in the self-assembly of pseudo metallocalix[6]arene complexes of general formulae:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3bbea1637440523bc1982498111966
https://hal.archives-ouvertes.fr/hal-01980935