Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Leigh E Wicki-Stordeur"'
Publikováno v:
Channels, Vol 17, Iss 1 (2023)
ABSTRACTMany neurological conditions exhibit synaptic impairments, suggesting mechanistic convergence. Additionally, the pannexin 1 (PANX1) channel and signaling scaffold is linked to several of these neurological conditions and is an emerging regula
Externí odkaz:
https://doaj.org/article/dd54ed127c554e1f90dbb9206c3133fb
Publikováno v:
Neural Regeneration Research, Vol 11, Iss 10, Pp 1540-1544 (2016)
We recently reported that targeted deletion of Pannexin 1 in neural precursor cells of the ventricular zone impairs the maintenance of these cells in healthy and stroke-injured brain. Here we frame this exciting new finding in the context of our prev
Externí odkaz:
https://doaj.org/article/a20f181a9d8f4ba0a800e7d1f6402239
Publikováno v:
Trends in neurosciences. 45(9)
Astrocytes play crucial roles in regulating brain circuit formation and physiology. Recent technological advances have revealed unprecedented levels of astrocyte diversity encompassing molecular, morphological, and functional differences. This divers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980068daa708e68894540ec26b66c709
https://pubmed.ncbi.nlm.nih.gov/35879116
https://pubmed.ncbi.nlm.nih.gov/35879116
Autor:
Nicholas L. Weilinger, Leigh E. Wicki-Stordeur, Christopher J. Groten, Jeffrey M. LeDue, Kristopher T. Kahle, Brian A. MacVicar
Publikováno v:
Cell Reports. 41:111556
Intracellular chloride ion concentration ([Cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9d854e22f3971d81932c52cde41c5f
https://doi.org/10.1016/j.celrep.2022.111556
https://doi.org/10.1016/j.celrep.2022.111556
The Pannexin 1 (Panx1) channel-forming protein is enriched in the central nervous system, and has been associated with several critical neurodevelopmental and plasticity functions; these include dendritic spine formation, neuronal network development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f06c7c3dde50949e552b14e34a3f257b
https://doi.org/10.1101/801563
https://doi.org/10.1101/801563
Autor:
Sarah N. Ebert, Juan C. Sanchez-Arias, Leigh E. Wicki-Stordeur, Anna L. Epp, Andrew K. J. Boyce, Leigh Anne Swayne
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
The Pannexin 1 (Panx1) ion and metabolite channel is expressed in a wide variety of cells where it regulates a number of cell behaviours including proliferation and differentiation. Panx1 is expressed on the cell surface as well as intracellular memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c235320a95ed173dc7f236b55f138e7
http://europepmc.org/articles/PMC6611761
http://europepmc.org/articles/PMC6611761
Autor:
Leigh Anne Swayne, Brian A. MacVicar, Leigh E. Wicki-Stordeur, Emma van der Slagt, Rebecca C. Candlish, Juan C. Sanchez Arias, Praveen P.N. Rao, Irina Paci
Publikováno v:
Cell Calcium. 90:102253
A new study by Yang and colleagues has revealed that TNF-alpha regulates PANX1 levels through an NF-kB-dependent mechanism in human endothelial cells. PANX1 modulates Ca2+ influx contributing to IL-1beta production independent of purinergic signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9700d6cce6c73f088de3881c3f7c64
https://doi.org/10.1016/j.ceca.2020.102253
https://doi.org/10.1016/j.ceca.2020.102253
Autor:
Xiaoxue Xu, Leigh E. Wicki-Stordeur, Juan C. Sanchez-Arias, Mei Liu, Maria S. Weaver, Catherine S. W. Choi, Leigh A. Swayne
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience
Neurite formation relies on finely-tuned control of the cytoskeleton. Here we identified a novel protein-protein interaction between the ion and metabolite channel protein Pannexin 1 (Panx1) and collapsin response mediator protein 2 (Crmp2), a positi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7e25e77ddcaa028aec7883506b4dce
http://journal.frontiersin.org/article/10.3389/fncel.2018.00124/full
http://journal.frontiersin.org/article/10.3389/fncel.2018.00124/full
Publikováno v:
Biochemical Journal. 470:319-330
The ubiquitous pannexin 1 (Panx1) ion- and metabolite-permeable channel mediates the release of ATP, a potent signalling molecule. In the present study, we provide striking evidence that ATP, in turn, stimulates internalization of Panx1 to intracellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058474c7e7f5e98bbc4962bc19845cbf
https://doi.org/10.1042/bj20141551
https://doi.org/10.1042/bj20141551
Publikováno v:
Channels. 8:110-117
Pannexins (Panxs) are a multifaceted family of ion and metabolite channels that play key roles in a number of physiological and pathophysiological settings. These single membrane large-pore channels exhibit a variety of tissue, cell type, and subcell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b504a360e85e5b97999abfe4ea19ab28
https://doi.org/10.4161/chan.27287
https://doi.org/10.4161/chan.27287