Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Leigh D Church"'
Publikováno v:
Biologics: Targets & Therapy, Vol 2008, Iss Issue 4, Pp 733-742 (2008)
Leigh D Church1, Sinisa Savic2, Michael F McDermott21Department of Rheumatology, Division of Immunity, Infection and Inflammation, Institute for Biomedical Research, The University of Birmingham, Birmingham, UK; 2Section of Musculoskeletal Disease, L
Externí odkaz:
https://doaj.org/article/7c1d1dc2c87d46f3a90f0e2b1d4596ab
Autor:
Nicola J Gullick, Hayley G Evans, Leigh D Church, David M Jayaraj, Andrew Filer, Bruce W Kirkham, Leonie S Taams
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12516 (2010)
Power Doppler ultrasound (PDUS) is increasingly used to assess synovitis in Rheumatoid Arthritis (RA). Prior studies have shown correlations between PDUS scores and vessel counts, but relationships with T cell immunopathology have not been described.
Externí odkaz:
https://doaj.org/article/8bf2fbbdb4d44f78b810f2395009b904
Autor:
Laura J. Dickie, Dawn L. Cooper, Maya H Buch, Sinisa Savic, Rebeccah J. Mathews, Ann W. Morgan, Domini Bryer, Janina Geiler, C. Wong, Michael F. McDermott, Leigh D Church, Paul Emery, Lydia R. Coulthard
Publikováno v:
Clinical and Experimental Immunology. 170:36-46
Summary Anti-tumour necrosis factor (TNF) biologics have revolutionized therapy of rheumatoid arthritis (RA). We compared the effects of infliximab on numbers of circulating leucocyte subsets in early RA (disease/symptom duration of ≤1 year) and la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f6479900ce868e52db30436d810002
https://doi.org/10.1111/j.1365-2249.2012.04626.x
https://doi.org/10.1111/j.1365-2249.2012.04626.x
Autor:
Graham A. Hitman, Tom Pettersson, Michael F. McDermott, Margo Whiteford, Shane McKee, Peter D. Arkwright, Belinda Nedjai, Annamari Ranki, Susanna Stjernberg, Mark D. Turner, Philip N. Hawkins, Leigh D Church, Kirsten Minden
Publikováno v:
Cellular Immunology. 268:55-59
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an autosomal dominant autoinflammatory condition caused by mutations in the TNFRSF1A gene which encodes the tumor necrosis factor (TNF) receptor, TNFR1. We investigated the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619db7ab7af083b67deaf565ce84db1b
https://doi.org/10.1016/j.cellimm.2011.02.007
https://doi.org/10.1016/j.cellimm.2011.02.007
Autor:
Michael F. McDermott, Leigh D Church
Publikováno v:
Expert Review of Clinical Immunology. 6:831-841
The cryopyrin-associated periodic syndromes (CAPS) are a group of rare inherited inflammatory diseases associated with overproduction of IL-1β. Canakinumab, developed by Novartis AG (Basel, Switzerland), is an intravenously or subcutaneously adminis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4441eb07a27a96df9ff578881d38050b
https://doi.org/10.1586/eci.10.66
https://doi.org/10.1586/eci.10.66
Autor:
Rebeccah J. Mathews, Leigh D Church, Michael F. McDermott, Paul Emery, Laura J. Dickie, Lydia R. Coulthard
Publikováno v:
Rheumatology. 49:1466-1471
Objective. To determine whether vitamin D3 modulates monocytic expression of intracellular Toll-like receptors (TLRs) 3, 7 and 9. Methods. Human monocytes were isolated from peripheral blood and cultured with 100 nM vitamin D3 for 24, 48 and 72 h. Ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c05d69ba93f8d3474946e55b20d2899
https://doi.org/10.1093/rheumatology/keq124
https://doi.org/10.1093/rheumatology/keq124
Publikováno v:
Biologics: Targets & Therapy, Vol 2008, Iss Issue 4, Pp 733-742 (2008)
Biologics : Targets & Therapy
Scopus-Elsevier
Biologics : Targets & Therapy
Scopus-Elsevier
Leigh D Church1, Sinisa Savic2, Michael F McDermott21Department of Rheumatology, Division of Immunity, Infection and Inflammation, Institute for Biomedical Research, The University of Birmingham, Birmingham, UK; 2Section of Musculoskeletal Disease, L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046338168f14a9466f9c69e5ad02a441
http://www.dovepress.com/long-term-management-of-patients-with-cryopyrin-associated-periodic-sy-a2476
http://www.dovepress.com/long-term-management-of-patients-with-cryopyrin-associated-periodic-sy-a2476
Publikováno v:
Clinical and Experimental Immunology. 153:86-95
Summary Stimulation of T lymphocytes results in the calcium-dependent activation and repression of a large number of genes. However, the functional response made by different T cell subsets is heterogeneous, as their differentiation results in altera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7919b11bdbb68cc9d8d17cebef5327d9
https://doi.org/10.1111/j.1365-2249.2008.03677.x
https://doi.org/10.1111/j.1365-2249.2008.03677.x
Autor:
Elaine Baguley, Graham A. Hitman, Sinisa Savic, Bruce Hayward, Mark D. Turner, Sarah M Churchman, Paul Emery, Lydia R. Coulthard, Leigh D Church, Hock Chye Gooi, Philip Wood, Rebeccah J. Mathews, Micheal F. McDermott, Belinda Nedjai
Publikováno v:
Annals of the Rheumatic Diseases. 67:1589-1595
Objective: To characterise and investigate the functional consequences of a novel TNFRSF1A splice site mutation causing tumour necrosis factor receptor associated periodic syndrome (TRAPS) in a 16-year-old male patient and his mother. Methods: Mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de64bb7ddafd10f770885293cba6919f
https://doi.org/10.1136/ard.2007.078667
https://doi.org/10.1136/ard.2007.078667
Publikováno v:
Springer Seminars in Immunopathology. 27:494-508
The term auto-inflammatory disorders has been coined to describe a group of conditions characterized by spontaneously relapsing and remitting bouts of systemic inflammation without apparent involvement of antigen-specific T cells or significant produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c390af309ca1ff72d43e8246ab9a70
https://doi.org/10.1007/s00281-006-0015-6
https://doi.org/10.1007/s00281-006-0015-6