Výsledky vyhledávání - "Leigh C. Murphy"

Akademický článek

Paracrine Crosstalk between Fibroblasts and ER+ Breast Cancer Cells Creates an IL1β-Enriched Niche that Promotes Tumor Growth

Autor: Sumanta Chatterjee, Vasudeva Bhat, Alexei Berdnikov, Jiahui Liu, Guihua Zhang, Edward Buchel, Janice Safneck, Aaron J. Marshall, Leigh C. Murphy, Lynne-Marie Postovit, Afshin Raouf

Publikováno v: iScience, Vol 19, Iss , Pp 388-401 (2019)

Summary: Breast cancer-induced activated fibroblasts support tumor progression. However, the role of normal fibroblasts in tumor progression remains controversial. In this study, we used modified patient-derived organoid cultures and demonstrate that

Externí odkaz: https://doaj.org/article/e2ec1c1892864a9d9d4ce305d8e93e07

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Akademický článek

A robust cell culture system for large scale feeder cell-free expansion of human breast epithelial progenitors

Autor: Sumanta Chatterjee, Pratima Basak, Edward Buchel, Leigh C. Murphy, Afshin Raouf

Publikováno v: Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-10 (2018)

Abstract Background Normal human breast epithelial cells are maintained by the proliferation and differentiation of different human breast epithelial progenitors (HBEPs). However, these progenitor subsets can only be obtained at low frequencies, limi

Externí odkaz: https://doaj.org/article/e8a123df9e3e442cabc3ef51483fa0db

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Akademický článek

Breast Cancers Activate Stromal Fibroblast-Induced Suppression of Progenitors in Adjacent Normal Tissue

Autor: Sumanta Chatterjee, Pratima Basak, Edward Buchel, Janice Safneck, Leigh C. Murphy, Michael Mowat, Sam K. Kung, Peter Eirew, Connie J. Eaves, Afshin Raouf

Publikováno v: Stem Cell Reports, Vol 10, Iss 1, Pp 196-211 (2018)

Summary: Human breast cancer cells are known to activate adjacent “normal-like” cells to enhance their own growth, but the cellular and molecular mechanisms involved are poorly understood. We now show by both phenotypic and functional measurement

Externí odkaz: https://doaj.org/article/cb6ea7e92cf84eb1ab188f9e5865042d

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