Zobrazeno 1 - 10
of 670
pro vyhledávání: '"Leigh Brown, A"'
Autor:
Steven Weaver, Vanessa M. Dávila Conn, Daniel Ji, Hannah Verdonk, Santiago Ávila-Ríos, Andrew J. Leigh Brown, Joel O. Wertheim, Sergei L. Kosakovsky Pond
Publikováno v:
Frontiers in Bioinformatics, Vol 4 (2024)
Molecular surveillance of viral pathogens and inference of transmission networks from genomic data play an increasingly important role in public health efforts, especially for HIV-1. For many methods, the genetic distance threshold used to connect se
Externí odkaz:
https://doaj.org/article/4224de6e5bd44b569093ce7fd9f1f999
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-9 (2023)
Abstract TDP-43 is an RNA-binding protein with a crucial nuclear role in splicing, and mislocalises from the nucleus to the cytoplasm in a range of neurodegenerative disorders. TDP-43 proteinopathy spans a spectrum of incurable, heterogeneous, and in
Externí odkaz:
https://doaj.org/article/c2741b5e80194d549e3f338eb6ddeb60
Autor:
Heather E. Grant, Sunando Roy, Rachel Williams, Helena Tutill, Bridget Ferns, Patricia A. Cane, J. Wilson Carswell, Deogratius Ssemwanga, Pontiano Kaleebu, Judith Breuer, Andrew J. Leigh Brown
Publikováno v:
Retrovirology, Vol 19, Iss 1, Pp 1-10 (2022)
Abstract We present 109 near full-length HIV genomes amplified from blood serum samples obtained during early 1986 from across Uganda, which to our knowledge is the earliest and largest population sample from the initial phase of the HIV epidemic in
Externí odkaz:
https://doaj.org/article/b9ce012fa63f4886844455303bb654f5
Autor:
Urša Šušnjar, Neva Škrabar, Anna-Leigh Brown, Yasmine Abbassi, Hemali Phatnani, NYGC ALS Consortium, Andrea Cortese, Cristina Cereda, Enrico Bugiardini, Rosanna Cardani, Giovanni Meola, Michela Ripolone, Maurizio Moggio, Maurizio Romano, Maria Secrier, Pietro Fratta, Emanuele Buratti
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
The aetiology of the TDP-43 aggregation manifest itself in the muscle and neuronal cells. Here authors show cell-type characteristic functions of TDP43, reflected in aberrant splicing, likely contributing to disease development.
Externí odkaz:
https://doaj.org/article/a2a3e5c080324289af930097b013f70e
Autor:
Hassan W. Kayondo, Alfred Ssekagiri, Grace Nabakooza, Nicholas Bbosa, Deogratius Ssemwanga, Pontiano Kaleebu, Samuel Mwalili, John M. Mango, Andrew J. Leigh Brown, Roberto A. Saenz, Ronald Galiwango, John M. Kitayimbwa
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-20 (2021)
Abstract Background Host population structure is a key determinant of pathogen and infectious disease transmission patterns. Pathogen phylogenetic trees are useful tools to reveal the population structure underlying an epidemic. Determining whether a
Externí odkaz:
https://doaj.org/article/f921303b4ec8402c97778b1b59c8ee53
Autor:
Ainur Sanaubarova, Emma Pujol-Hodge, Natalya Dzissyuk, Philippe Lemey, Sten H. Vermund, Andrew J. Leigh Brown, Syed Ali
Publikováno v:
Viruses, Vol 15, Iss 7, p 1407 (2023)
HIV incidence in Kazakhstan increased by 73% between 2010 and 2020, with an estimated 35,000 people living with HIV (PLHIV) in 2020. The development of antiretroviral drug resistance is a major threat to effective antiretroviral therapy (ART), yet st
Externí odkaz:
https://doaj.org/article/9f048c23a3d8434fbc83390d5e5ff673
Autor:
Nitin Roper, Moises J. Velez, Alberto Chiappori, Yoo Sun Kim, Jun S. Wei, Sivasish Sindiri, Nobuyuki Takahashi, Deborah Mulford, Suresh Kumar, Kris Ylaya, Christopher Trindade, Irena Manukyan, Anna-Leigh Brown, Jane B. Trepel, Jung-Min Lee, Stephen Hewitt, Javed Khan, Anish Thomas
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Immune checkpoint blockade (ICB) benefits only a small subset of patients with small cell lung cancer (SCLC) and the mechanisms driving benefit are poorly understood. Here, the authors show that elevated Notch signaling predicts clinical benefit in I
Externí odkaz:
https://doaj.org/article/14cd7395b4e240a6a4c5e9753ff63101
Autor:
Oliver T. Stirrup, Caroline A. Sabin, Andrew N. Phillips, Ian Williams, Duncan Churchill, Anna Tostevin, Teresa Hill, David T. Dunn, David Asboe, Anton Pozniak, Patricia Cane, David Chadwick, Duncan Clark, Simon Collins, Valerie Delpech, Samuel Douthwaite, David Dunn, Esther Fearnhill, Kholoud Porter, Oliver Stirrup, Christophe Fraser, Anna Maria Geretti, Rory Gunson, Antony Hale, Stéphane Hué, Linda Lazarus, Andrew Leigh-Brown, Tamyo Mbisa, Nicola Mackie, Chloe Orkin, Eleni Nastouli, Deenan Pillay, Andrew Phillips, Caroline Sabin, Erasmus Smit, Kate Templeton, Peter Tilston, Erik Volz, Hongyi Zhang, Keith Fairbrother, Justine Dawkins, Siobhan O’Shea, Jane Mullen, Alison Cox, Richard Tandy, Tracy Fawcett, Mark Hopkins, Clare Booth, Lynne Renwick, Matthias L. Schmid, Brendan Payne, Jonathan Hubb, Simon Dustan, Stuart Kirk, Amanda Bradley-Stewart, Sophie Jose, Alicia Thornton, Susie Huntington, Adam Glabay, Shaadi Shidfar, Janet Lynch, James Hand, Carl de Souza, Nicky Perry, Stuart Tilbury, Elaney Youssef, Brian Gazzard, Mark Nelson, Tracey Mabika, Sundhiya Mandalia, Jane Anderson, Sajid Munshi, Frank Post, Ade Adefisan, Chris Taylor, Zachary Gleisner, Fowzia Ibrahim, Lucy Campbell, Kirsty Baillie, Richard Gilson, Nataliya Brima, Jonathan Ainsworth, Achim Schwenk, Sheila Miller, Chris Wood, Margaret Johnson, Mike Youle, Fiona Lampe, Colette Smith, Rob Tsintas, Clinton Chaloner, Samantha Hutchinson, John Walsh, Nicky Mackie, Alan Winston, Jonathan Weber, Farhan Ramzan, Mark Carder, Clifford Leen, Alan Wilson, Sheila Morris, Mark Gompels, Sue Allan, Adrian Palfreeman, Adam Lewszuk, Stephen Kegg, Akin Faleye, Victoria Ogunbiyi, Sue Mitchell, Phillip Hay, Christian Kemble, Fabiola Martin, Sarah Russell-Sharpe, Janet Gravely, Sris Allan, Andrew Harte, Anjum Tariq, Hazel Spencer, Ron Jones, Jillian Pritchard, Shirley Cumming, Claire Atkinson, Dushyant Mital, Veronica Edgell, Juli Allen, Andy Ustianowski, Cynthia Murphy, Ilise Gunder, Roy Trevelion, Abdel Babiker
Publikováno v:
Journal of Virus Eradication, Vol 5, Iss 4, Pp 204-211 (2019)
Objectives: The aim of this study was to investigate associations between baseline characteristics and CD4 cell count response on first-line antiretroviral therapy and risk of virological failure (VF) with or without drug resistance. Methods: We cond
Externí odkaz:
https://doaj.org/article/b685ef625be34b15b9ad4ef446718de6
Autor:
Oliver Ratmann, M. Kate Grabowski, Matthew Hall, Tanya Golubchik, Chris Wymant, Lucie Abeler-Dörner, David Bonsall, Anne Hoppe, Andrew Leigh Brown, Tulio de Oliveira, Astrid Gall, Paul Kellam, Deenan Pillay, Joseph Kagaayi, Godfrey Kigozi, Thomas C. Quinn, Maria J. Wawer, Oliver Laeyendecker, David Serwadda, Ronald H. Gray, Christophe Fraser, PANGEA Consortium and Rakai Health Sciences Program
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Here, Ratmann et al. show how viral deep sequencing data can be used to reconstruct HIV-1 transmission networks and to infer the direction of transmission in these networks.
Externí odkaz:
https://doaj.org/article/8e75db6f112d4dba8e390f4974b4825a
Autor:
Emma Pujol-Hodge, Jesus F. Salazar-Gonzalez, Deogratius Ssemwanga, Edwin D. Charlebois, James Ayieko, Heather E. Grant, Teri Liegler, Katherine E. Atkins, Pontiano Kaleebu, Moses R. Kamya, Maya Petersen, Diane V. Havlir, Andrew J. Leigh Brown
Publikováno v:
Viruses, Vol 14, Iss 8, p 1673 (2022)
The Sustainable East Africa Research in Community Health (SEARCH) trial was a universal test-and-treat (UTT) trial in rural Uganda and Kenya, aiming to lower regional HIV-1 incidence. Here, we quantify breakthrough HIV-1 transmissions occurring durin
Externí odkaz:
https://doaj.org/article/3a26563fb65c4816806f3378346885d5