Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Leigh Ann Perkins"'
Controlled Clinical Trial of Dichloroacetate for Treatment of Congenital Lactic Acidosis in Children
Autor:
Janet H. Silverstein, Richard E. Neiberger, Douglas W. Theriaque, Alan D. Hutson, Robin L. Gilmore, Jonathan J. Shuster, Douglas S. Kerr, Paul R. Carney, Eileen M. Fennell, Albert L. Shroads, Leigh Ann Perkins, George N. Henderson, Ronald G. Quisling, Natalia M. Felitsyn, S. Terri Bunch, Melvin Greer, Carie L. Barnes, Ralph G. O'Brien, Edward Valenstein, Peter W. Stacpoole
Publikováno v:
Pediatrics. 117:1519-1531
OBJECTIVE. Open-label studies indicate that oral dichloroacetate (DCA) may be effective in treating patients with congenital lactic acidosis. We tested this hypothesis by conducting the first double-blind, randomized, control trial of DCA in this dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ad86cb1ca492ff04a9f55cd183b5d5
https://doi.org/10.1542/peds.2005-1226
https://doi.org/10.1542/peds.2005-1226
Autor:
Edward Valenstein, Richard E. Neiberger, Leigh Ann Perkins, David E. Stickler, Jonathan J. Shuster, Douglas W. Theriaque, Peter W. Stacpoole, Paul R. Carney
Publikováno v:
Pediatric Neurology. 34:127-131
Peripheral neuropathy is an underrecognized but common occurrence in genetic mitochondrial disorders. To gain insight into the frequency and clinical presentation of this complication, nerve conduction studies were performed on 43 subjects with conge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86abc1ca6fe2ca1216e6ad45811bd60c
https://doi.org/10.1016/j.pediatrneurol.2005.08.006
https://doi.org/10.1016/j.pediatrneurol.2005.08.006
Autor:
Richard E. Neiberger, Peter W. Stacpoole, Glen E. Duncan, Douglas W. Theriaque, Leigh Ann Perkins
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 89:1733-1738
We determined acute and chronic effects of dichloroacetate (DCA) on maximal (MAX) and submaximal (SUB) exercise responses in patients with abnormal mitochondrial energetics. Subjects (n = 9) completed a MAX treadmill bout 1 h after ingesting 25 mg/kg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f58cfa6d01450a9539402e35f3ede7
https://doi.org/10.1210/jc.2003-031684
https://doi.org/10.1210/jc.2003-031684
Autor:
Leigh Ann Perkins, Alan D. Hutson, Peter W. Stacpoole, Douglas W. Theriaque, Richard E. Neiberger, Jaime C. George
Publikováno v:
American Journal of Kidney Diseases. 39:12-23
Congenital lactic acidoses (CLAs) constitute a group of rare inborn errors of mitochondrial metabolism in which cellular energy failure is the defining biochemical abnormality. We report the principal manifestations of renal dysfunction in 35 childre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27988a738cf75fa61f18e65f9308412
https://doi.org/10.1053/ajkd.2002.29872
https://doi.org/10.1053/ajkd.2002.29872
Autor:
Melvin Greer, Leigh Ann Perkins, Ronald G. Quisling, Richard E. Neiberger, Alan D. Hutson, Peter W. Stacpoole, S.T. Bunch
Publikováno v:
The Journal of Pediatrics. 134:99-102
In 27 of 28 children with congenital lactic acidosis, cerebrospinal fluid lactate was higher than venous blood lactate. The mean +/- SEM difference between these variables was 2.4 +/- 0.3 mmol/L (P =.0001). Girls or patients with pyruvate dehydrogena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e15d92ae139242c26541c8462dc7b50
https://doi.org/10.1016/s0022-3476(99)70379-3
https://doi.org/10.1016/s0022-3476(99)70379-3
Publikováno v:
Pediatric neurosurgery. 45(5)
Background/Aims: Chiari II malformation represents a group of developmental abnormalities involving the caudal displacement of the cervicomedullary junction, pons, fourth ventricle, and medulla. This constellation of malformations is strongly associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c6dce1c09dc2093b1c5a774abcd42a2
https://pubmed.ncbi.nlm.nih.gov/19907196
https://pubmed.ncbi.nlm.nih.gov/19907196
Autor:
David W. Pincus, Mark A. Clayman, Leigh Ann Perkins, M. Brent Seagle, Gregory J. A. Murad, Sno E. White
Publikováno v:
Neurosurgical focus. 19(6)
ObjectThe goal of the craniofacial surgeon has always been the correction of form and function with prevention of associated morbidity and death. Through the pioneering work of Jimenez and Barone, minimally invasive approaches to the surgical correct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dccaad8527e7f8431af3e276a67b9063
https://pubmed.ncbi.nlm.nih.gov/16398483
https://pubmed.ncbi.nlm.nih.gov/16398483
Autor:
Roderick Stallworth, Leigh Ann Perkins, Lawrence Johnston, Michael Tinker, Luke Schutzenhofer, Sandra Blalock, Janet Sisk, Katherine Mims
Publikováno v:
36th Structures, Structural Dynamics and Materials Conference.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e42586b3abe67dd5eb5bb7ccfec03341
https://doi.org/10.2514/6.1995-1473
https://doi.org/10.2514/6.1995-1473
Publikováno v:
Medicine & Science in Sports & Exercise. 35:S97
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8f0686694a0fd3b224ed34ac96a579c
https://doi.org/10.1097/00005768-200305001-00535
https://doi.org/10.1097/00005768-200305001-00535
Publikováno v:
Pediatric Neurosurgery; Dec2009, Vol. 45 Issue 5, p337-344, 8p, 8 Black and White Photographs