Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Leigh Ann Burns Naas"'
Autor:
Douglas A. Keller, Arianna Bassan, Alexander Amberg, Leigh Ann Burns Naas, Jon Chambers, Kevin Cross, Frances Hall, Gloria D. Jahnke, Amarjit Luniwal, Serena Manganelli, Jordi Mestres, Amy L. Mihalchik-Burhans, David Woolley, Raymond R. Tice
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
In silico toxicology protocols are meant to support computationally-based assessments using principles that ensure that results can be generated, recorded, communicated, archived, and then evaluated in a uniform, consistent, and reproducible manner.
Externí odkaz:
https://doaj.org/article/662e50fa83754807891531c6e030ecd7
Autor:
Carrie McMahon, James L Trevaskis, Christoph Carter, Kevin Holsapple, Kirsten White, Moupali Das, Sean Collins, Hal Martin, Leigh Ann Burns-Naas
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0229617 (2020)
An increasing prevalence of overweight and obesity in people living with HIV has been associated with initiation of antiretroviral therapy with integrase strand transfer inhibitors (INSTIs). An off-target inhibition of the endogenous ligand binding t
Externí odkaz:
https://doaj.org/article/0df0eef0bcb74cc29fe1d69a6a77af46
Autor:
Shubha Bagrodia, Leigh Ann Burns-Naas, Cynthia L. Palmer, Shinji Yamazaki, Tod Smeal, Lisa D. Marroquin, Gabriel Troche, Winston Evering, Annette John-Baptiste, Wenyue Hu, Donald Wojciechowicz, Vince R. Torti
PDF file, 141K, Photographs of canine muzzles showing skin flushing following PF-04880594 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61562c2ac8f9673fec0772416b1013c
https://doi.org/10.1158/1535-7163.22497447
https://doi.org/10.1158/1535-7163.22497447
Autor:
Shubha Bagrodia, Leigh Ann Burns-Naas, Cynthia L. Palmer, Shinji Yamazaki, Tod Smeal, Lisa D. Marroquin, Gabriel Troche, Winston Evering, Annette John-Baptiste, Wenyue Hu, Donald Wojciechowicz, Vince R. Torti
PDF file, 75K, Body weight changes in nude mice administered RAF inhibitor (PF-04880594) are maintained in mice co-treated with MEK inhibitor (PD-0325901).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db70ae0a991103300fbe4c5905e2f65b
https://doi.org/10.1158/1535-7163.22497450
https://doi.org/10.1158/1535-7163.22497450
Autor:
Shubha Bagrodia, Leigh Ann Burns-Naas, Cynthia L. Palmer, Shinji Yamazaki, Tod Smeal, Lisa D. Marroquin, Gabriel Troche, Winston Evering, Annette John-Baptiste, Wenyue Hu, Donald Wojciechowicz, Vince R. Torti
Clinical trials of selective RAF inhibitors in patients with melanoma tumors harboring activated BRAFV600E have produced very promising results, and a RAF inhibitor has been approved for treatment of advanced melanoma. However, about a third of patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a4d07dbcb6946cf564cc5a49bca70c
https://doi.org/10.1158/1535-7163.c.6535623
https://doi.org/10.1158/1535-7163.c.6535623
Autor:
Shubha Bagrodia, Leigh Ann Burns-Naas, Cynthia L. Palmer, Shinji Yamazaki, Tod Smeal, Lisa D. Marroquin, Gabriel Troche, Winston Evering, Annette John-Baptiste, Wenyue Hu, Donald Wojciechowicz, Vince R. Torti
PDF file, 39K, Relationship between oral doses and average plasma concentrations of PD-0325901 in athymic nu/nu mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556345971e072ef862c9dc4beaaaf8d6
https://doi.org/10.1158/1535-7163.22497453.v1
https://doi.org/10.1158/1535-7163.22497453.v1
Autor:
Shubha Bagrodia, Leigh Ann Burns-Naas, Cynthia L. Palmer, Shinji Yamazaki, Tod Smeal, Lisa D. Marroquin, Gabriel Troche, Winston Evering, Annette John-Baptiste, Wenyue Hu, Donald Wojciechowicz, Vince R. Torti
PDF file, 66K.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506d7abfc15055ce5c5f19c73f418059
https://doi.org/10.1158/1535-7163.22497444.v1
https://doi.org/10.1158/1535-7163.22497444.v1
Autor:
April D Lake, Kevin Holsapple, Tanya McDonnell, Joseph C Arezzo, Ricardo Ramirez, Lindsay Gamelin, Mei Yu, Dylan Glatt, Ryan Dick, Xiaodong Xie, Regina Choy, Guofeng Cheng, Chin H Tay, Anne Chester, Darryl Kato, Leigh Ann Burns-Naas
Publikováno v:
Toxicological Sciences. 186:298-308
The nonclinical safety profile of GS-8873, a hepatitis B virus RNA transcript inhibitor was evaluated in rat and monkey 13-week toxicity studies with 8-week recovery phases. Vehicle or GS-8873 was dosed orally for 13 weeks at 2, 6, 20, and 60 mg/kg/d
Publikováno v:
International Journal of Toxicology. :109158182311718
Certification in toxicology remains a subject of interest to those in the field, as evidenced by the number of presentations at major meetings and publications in the past decade. In 2009, Brock and colleagues summarized the certifications available
Autor:
Leigh Ann Burns-Naas, Anne E. Chester, Ruth Roberts, Eric Paoli, Joy Y. Feng, Michael L. Mitchell, Mark Osier, Claire Sadler, Roman Sakowicz, Richard A. Campbell, Yili Xu, Phumzile Sikakana, Jianhong Wang
Publikováno v:
Roberts, R A, Campbell, R A, Sikakana, P, Sadler, C, Osier, M, Xu, Y, Feng, J Y, Mitchell, M, Sakowicz, R, Chester, A, Paoli, E, Wang, J & Burns-naas, L A 2021, ' Species-Specific Urothelial Toxicity With an Anti-HIV Noncatalytic Site Integrase Inhibitor (NCINI) Is Related to Unusual pH-Dependent Physicochemical Changes ', Toxicological Sciences, vol. 183, no. 1, pp. 105-116 . https://doi.org/10.1093/toxsci/kfab073
GS-9695 and GS-9822 are next-generation noncatalytic site integrase inhibitors (NCINIs) with significantly improved potency against human immunodeficiency virus compared with previous drugs such as BI-224436. Development stopped due to vacuolation of