Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Leigh Ann Burns Naas"'
Autor:
Arianna Bassan, Ronald Steigerwalt, Douglas Keller, Lisa Beilke, Paul M. Bradley, Frank Bringezu, William J. Brock, Leigh Ann Burns-Naas, Jon Chambers, Kevin Cross, Michael Dorato, Rosalie Elespuru, Douglas Fuhrer, Frances Hall, Jim Hartke, Gloria D. Jahnke, Felix M. Kluxen, Eric McDuffie, Friedemann Schmidt, Jean-Pierre Valentin, David Woolley, Doris Zane, Glenn J. Myatt
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
The ICH S1B carcinogenicity global testing guideline has been recently revised with a novel addendum that describes a comprehensive integrated Weight of Evidence (WoE) approach to determine the need for a 2-year rat carcinogenicity study. In the pres
Externí odkaz:
https://doaj.org/article/3419c3b90a414f7aafa8e7a2a11aedc0
Autor:
Douglas A. Keller, Arianna Bassan, Alexander Amberg, Leigh Ann Burns Naas, Jon Chambers, Kevin Cross, Frances Hall, Gloria D. Jahnke, Amarjit Luniwal, Serena Manganelli, Jordi Mestres, Amy L. Mihalchik-Burhans, David Woolley, Raymond R. Tice
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
In silico toxicology protocols are meant to support computationally-based assessments using principles that ensure that results can be generated, recorded, communicated, archived, and then evaluated in a uniform, consistent, and reproducible manner.
Externí odkaz:
https://doaj.org/article/662e50fa83754807891531c6e030ecd7
Autor:
Carrie McMahon, James L Trevaskis, Christoph Carter, Kevin Holsapple, Kirsten White, Moupali Das, Sean Collins, Hal Martin, Leigh Ann Burns-Naas
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0229617 (2020)
An increasing prevalence of overweight and obesity in people living with HIV has been associated with initiation of antiretroviral therapy with integrase strand transfer inhibitors (INSTIs). An off-target inhibition of the endogenous ligand binding t
Externí odkaz:
https://doaj.org/article/0df0eef0bcb74cc29fe1d69a6a77af46
Autor:
Shubha Bagrodia, Leigh Ann Burns-Naas, Cynthia L. Palmer, Shinji Yamazaki, Tod Smeal, Lisa D. Marroquin, Gabriel Troche, Winston Evering, Annette John-Baptiste, Wenyue Hu, Donald Wojciechowicz, Vince R. Torti
PDF file, 141K, Photographs of canine muzzles showing skin flushing following PF-04880594 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61562c2ac8f9673fec0772416b1013c
https://doi.org/10.1158/1535-7163.22497447
https://doi.org/10.1158/1535-7163.22497447
Autor:
Shubha Bagrodia, Leigh Ann Burns-Naas, Cynthia L. Palmer, Shinji Yamazaki, Tod Smeal, Lisa D. Marroquin, Gabriel Troche, Winston Evering, Annette John-Baptiste, Wenyue Hu, Donald Wojciechowicz, Vince R. Torti
PDF file, 75K, Body weight changes in nude mice administered RAF inhibitor (PF-04880594) are maintained in mice co-treated with MEK inhibitor (PD-0325901).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db70ae0a991103300fbe4c5905e2f65b
https://doi.org/10.1158/1535-7163.22497450
https://doi.org/10.1158/1535-7163.22497450
Autor:
Shubha Bagrodia, Leigh Ann Burns-Naas, Cynthia L. Palmer, Shinji Yamazaki, Tod Smeal, Lisa D. Marroquin, Gabriel Troche, Winston Evering, Annette John-Baptiste, Wenyue Hu, Donald Wojciechowicz, Vince R. Torti
Clinical trials of selective RAF inhibitors in patients with melanoma tumors harboring activated BRAFV600E have produced very promising results, and a RAF inhibitor has been approved for treatment of advanced melanoma. However, about a third of patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a4d07dbcb6946cf564cc5a49bca70c
https://doi.org/10.1158/1535-7163.c.6535623
https://doi.org/10.1158/1535-7163.c.6535623
Autor:
Shubha Bagrodia, Leigh Ann Burns-Naas, Cynthia L. Palmer, Shinji Yamazaki, Tod Smeal, Lisa D. Marroquin, Gabriel Troche, Winston Evering, Annette John-Baptiste, Wenyue Hu, Donald Wojciechowicz, Vince R. Torti
PDF file, 39K, Relationship between oral doses and average plasma concentrations of PD-0325901 in athymic nu/nu mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556345971e072ef862c9dc4beaaaf8d6
https://doi.org/10.1158/1535-7163.22497453.v1
https://doi.org/10.1158/1535-7163.22497453.v1
Autor:
Shubha Bagrodia, Leigh Ann Burns-Naas, Cynthia L. Palmer, Shinji Yamazaki, Tod Smeal, Lisa D. Marroquin, Gabriel Troche, Winston Evering, Annette John-Baptiste, Wenyue Hu, Donald Wojciechowicz, Vince R. Torti
PDF file, 66K.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506d7abfc15055ce5c5f19c73f418059
https://doi.org/10.1158/1535-7163.22497444.v1
https://doi.org/10.1158/1535-7163.22497444.v1
Autor:
April D Lake, Kevin Holsapple, Tanya McDonnell, Joseph C Arezzo, Ricardo Ramirez, Lindsay Gamelin, Mei Yu, Dylan Glatt, Ryan Dick, Xiaodong Xie, Regina Choy, Guofeng Cheng, Chin H Tay, Anne Chester, Darryl Kato, Leigh Ann Burns-Naas
Publikováno v:
Toxicological Sciences. 186:298-308
The nonclinical safety profile of GS-8873, a hepatitis B virus RNA transcript inhibitor was evaluated in rat and monkey 13-week toxicity studies with 8-week recovery phases. Vehicle or GS-8873 was dosed orally for 13 weeks at 2, 6, 20, and 60 mg/kg/d
Publikováno v:
International Journal of Toxicology. :109158182311718
Certification in toxicology remains a subject of interest to those in the field, as evidenced by the number of presentations at major meetings and publications in the past decade. In 2009, Brock and colleagues summarized the certifications available