Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Leigh Ann Burns"'
Autor:
Arianna Bassan, Ronald Steigerwalt, Douglas Keller, Lisa Beilke, Paul M. Bradley, Frank Bringezu, William J. Brock, Leigh Ann Burns-Naas, Jon Chambers, Kevin Cross, Michael Dorato, Rosalie Elespuru, Douglas Fuhrer, Frances Hall, Jim Hartke, Gloria D. Jahnke, Felix M. Kluxen, Eric McDuffie, Friedemann Schmidt, Jean-Pierre Valentin, David Woolley, Doris Zane, Glenn J. Myatt
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
The ICH S1B carcinogenicity global testing guideline has been recently revised with a novel addendum that describes a comprehensive integrated Weight of Evidence (WoE) approach to determine the need for a 2-year rat carcinogenicity study. In the pres
Externí odkaz:
https://doaj.org/article/3419c3b90a414f7aafa8e7a2a11aedc0
Autor:
Douglas A. Keller, Arianna Bassan, Alexander Amberg, Leigh Ann Burns Naas, Jon Chambers, Kevin Cross, Frances Hall, Gloria D. Jahnke, Amarjit Luniwal, Serena Manganelli, Jordi Mestres, Amy L. Mihalchik-Burhans, David Woolley, Raymond R. Tice
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
In silico toxicology protocols are meant to support computationally-based assessments using principles that ensure that results can be generated, recorded, communicated, archived, and then evaluated in a uniform, consistent, and reproducible manner.
Externí odkaz:
https://doaj.org/article/662e50fa83754807891531c6e030ecd7
Autor:
Carrie McMahon, James L Trevaskis, Christoph Carter, Kevin Holsapple, Kirsten White, Moupali Das, Sean Collins, Hal Martin, Leigh Ann Burns-Naas
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0229617 (2020)
An increasing prevalence of overweight and obesity in people living with HIV has been associated with initiation of antiretroviral therapy with integrase strand transfer inhibitors (INSTIs). An off-target inhibition of the endogenous ligand binding t
Externí odkaz:
https://doaj.org/article/0df0eef0bcb74cc29fe1d69a6a77af46
Akademický článek
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Autor:
Shubha Bagrodia, Leigh Ann Burns-Naas, Cynthia L. Palmer, Shinji Yamazaki, Tod Smeal, Lisa D. Marroquin, Gabriel Troche, Winston Evering, Annette John-Baptiste, Wenyue Hu, Donald Wojciechowicz, Vince R. Torti
PDF file, 141K, Photographs of canine muzzles showing skin flushing following PF-04880594 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61562c2ac8f9673fec0772416b1013c
https://doi.org/10.1158/1535-7163.22497447
https://doi.org/10.1158/1535-7163.22497447
Autor:
Shubha Bagrodia, Leigh Ann Burns-Naas, Cynthia L. Palmer, Shinji Yamazaki, Tod Smeal, Lisa D. Marroquin, Gabriel Troche, Winston Evering, Annette John-Baptiste, Wenyue Hu, Donald Wojciechowicz, Vince R. Torti
PDF file, 75K, Body weight changes in nude mice administered RAF inhibitor (PF-04880594) are maintained in mice co-treated with MEK inhibitor (PD-0325901).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db70ae0a991103300fbe4c5905e2f65b
https://doi.org/10.1158/1535-7163.22497450
https://doi.org/10.1158/1535-7163.22497450
Autor:
Shubha Bagrodia, Leigh Ann Burns-Naas, Cynthia L. Palmer, Shinji Yamazaki, Tod Smeal, Lisa D. Marroquin, Gabriel Troche, Winston Evering, Annette John-Baptiste, Wenyue Hu, Donald Wojciechowicz, Vince R. Torti
Clinical trials of selective RAF inhibitors in patients with melanoma tumors harboring activated BRAFV600E have produced very promising results, and a RAF inhibitor has been approved for treatment of advanced melanoma. However, about a third of patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a4d07dbcb6946cf564cc5a49bca70c
https://doi.org/10.1158/1535-7163.c.6535623
https://doi.org/10.1158/1535-7163.c.6535623
Autor:
Shubha Bagrodia, Leigh Ann Burns-Naas, Cynthia L. Palmer, Shinji Yamazaki, Tod Smeal, Lisa D. Marroquin, Gabriel Troche, Winston Evering, Annette John-Baptiste, Wenyue Hu, Donald Wojciechowicz, Vince R. Torti
PDF file, 39K, Relationship between oral doses and average plasma concentrations of PD-0325901 in athymic nu/nu mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556345971e072ef862c9dc4beaaaf8d6
https://doi.org/10.1158/1535-7163.22497453.v1
https://doi.org/10.1158/1535-7163.22497453.v1
Autor:
Shubha Bagrodia, Leigh Ann Burns-Naas, Cynthia L. Palmer, Shinji Yamazaki, Tod Smeal, Lisa D. Marroquin, Gabriel Troche, Winston Evering, Annette John-Baptiste, Wenyue Hu, Donald Wojciechowicz, Vince R. Torti
PDF file, 66K.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506d7abfc15055ce5c5f19c73f418059
https://doi.org/10.1158/1535-7163.22497444.v1
https://doi.org/10.1158/1535-7163.22497444.v1
Autor:
April D Lake, Kevin Holsapple, Tanya McDonnell, Joseph C Arezzo, Ricardo Ramirez, Lindsay Gamelin, Mei Yu, Dylan Glatt, Ryan Dick, Xiaodong Xie, Regina Choy, Guofeng Cheng, Chin H Tay, Anne Chester, Darryl Kato, Leigh Ann Burns-Naas
Publikováno v:
Toxicological Sciences. 186:298-308
The nonclinical safety profile of GS-8873, a hepatitis B virus RNA transcript inhibitor was evaluated in rat and monkey 13-week toxicity studies with 8-week recovery phases. Vehicle or GS-8873 was dosed orally for 13 weeks at 2, 6, 20, and 60 mg/kg/d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72019e0b0b0a251453a80ddac1615d2b
https://doi.org/10.1093/toxsci/kfac009
https://doi.org/10.1093/toxsci/kfac009