Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Leigh A. Swayne"'
Autor:
Xiaoxue Xu, Leigh E. Wicki-Stordeur, Juan C. Sanchez-Arias, Mei Liu, Maria S. Weaver, Catherine S. W. Choi, Leigh A. Swayne
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Neurite formation relies on finely-tuned control of the cytoskeleton. Here we identified a novel protein-protein interaction between the ion and metabolite channel protein Pannexin 1 (Panx1) and collapsin response mediator protein 2 (Crmp2), a positi
Externí odkaz:
https://doaj.org/article/32350df21d5741dbaff2471394c10375
Autor:
Leigh A. Swayne, Andrew K. J. Boyce
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Pannexin 1 (Panx1) channels are widely recognized for their role in ATP release, and as follows, their function is closely tied to that of ATP-activated P2X7 purinergic receptors (P2X7Rs). Our recent work has shown that extracellular ATP induces clus
Externí odkaz:
https://doaj.org/article/221fa5a55e5c45139193c26a5e921c33
Publikováno v:
Channels, Vol 17, Iss 1 (2023)
ABSTRACTMany neurological conditions exhibit synaptic impairments, suggesting mechanistic convergence. Additionally, the pannexin 1 (PANX1) channel and signaling scaffold is linked to several of these neurological conditions and is an emerging regula
Externí odkaz:
https://doaj.org/article/dd54ed127c554e1f90dbb9206c3133fb
Autor:
Nicole S. York, Juan C. Sanchez-Arias, Alexa C. H. McAdam, Joel E. Rivera, Laura T. Arbour, Leigh Anne Swayne
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
The ANK2 gene encodes for ankyrin-B (ANKB), one of 3 members of the ankyrin family of proteins, whose name is derived from the Greek word for anchor. ANKB was originally identified in the brain (B denotes “brain”) but has become most widely known
Externí odkaz:
https://doaj.org/article/999eed3ba63d4704ad6e434ca89c1be3
Autor:
Juan C. Sanchez-Arias, Micaël Carrier, Simona D. Frederiksen, Olga Shevtsova, Chloe McKee, Emma van der Slagt, Elisa Gonçalves de Andrade, Hai Lam Nguyen, Penelope A. Young, Marie-Ève Tremblay, Leigh Anne Swayne
Publikováno v:
Frontiers in Neuroanatomy, Vol 15 (2021)
The ever-expanding availability and evolution of microscopy tools has enabled ground-breaking discoveries in neurobiology, particularly with respect to the analysis of cell-type density and distribution. Widespread implementation of many of the elega
Externí odkaz:
https://doaj.org/article/4b094bc79d59432e86e9ad5035daf280
Autor:
Karen V. Lithgow, Emily Tsao, Ethan Schovanek, Alloysius Gomez, Leigh Anne Swayne, Caroline E. Cameron
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Treponema pallidum subspecies pallidum, the causative agent of syphilis, traverses the vascular endothelium to gain access to underlying tissue sites. Herein, we investigate the mechanisms associated with T. pallidum traversal of endothelial barriers
Externí odkaz:
https://doaj.org/article/41389e2999cf459f9ab5ccc3962512a1
Autor:
Karen V. Lithgow, Brigette Church, Alloysius Gomez, Emily Tsao, Simon Houston, Leigh Anne Swayne, Caroline E. Cameron
Publikováno v:
mSphere, Vol 5, Iss 2 (2020)
ABSTRACT Treponema pallidum subsp. pallidum is the causative agent of syphilis, a human-specific sexually transmitted infection that causes a multistage disease with diverse clinical manifestations. Treponema pallidum undergoes rapid vascular dissemi
Externí odkaz:
https://doaj.org/article/57571949b48c4a86af8ec569bcdf5b56
Autor:
Juan C. Sanchez-Arias, Brant E. Isakson, Alexander W. Lohman, Silvia Penuela, Abigail G. Wolpe, Miranda E. Good, X. Michael Koval, Leigh Anne Swayne, Chen Seng Ng, Scott R. Johnstone, Victor E. Laubach
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology
Anatomy and Cell Biology Publications
Anatomy and Cell Biology Publications
Copyright © 2020 the American Physiological Society Pannexin 1 (PANX1) is a ubiquitously expressed, channel-forming protein found in a number of tissues throughout the body (e.g., lung, vasculature, liver, central nervous system, immune system) that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12a188afec7a7c70aa9377f0461004b
http://europepmc.org/articles/PMC7347959
http://europepmc.org/articles/PMC7347959
Publikováno v:
Biochemistry and Cell Biology. 98:299-306
Ankyrin-B (AnkB) is scaffolding protein that anchors integral membrane proteins to the cardiomyocyte cytoskeleton. We recently identified an AnkB variant, AnkB p.S646F (ANK2 c.1937 C>T) associated with a phenotype ranging from predisposition for card
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c427fe46c3ee40a52143b8ca6788d0
https://doi.org/10.1139/bcb-2019-0082
https://doi.org/10.1139/bcb-2019-0082
Publikováno v:
Trends in neurosciences. 45(9)
Astrocytes play crucial roles in regulating brain circuit formation and physiology. Recent technological advances have revealed unprecedented levels of astrocyte diversity encompassing molecular, morphological, and functional differences. This divers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980068daa708e68894540ec26b66c709
https://pubmed.ncbi.nlm.nih.gov/35879116
https://pubmed.ncbi.nlm.nih.gov/35879116