Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Leigh A. Stoddart"'
Autor:
Emanuela Talamonti, Jelena Davegardh, Anastasia Kalinovich, Sten M.M. van Beek, Nodi Dehvari, Carina Halleskog, Hamza M. Bokhari, Dana S. Hutchinson, Seungmin Ham, Laura J. Humphrys, Nicola C. Dijon, Aikaterini Motso, Anna Sandstrom, Evelyn Zacharewicz, Ilga Mutule, Edgars Suna, Jana Spura, Karolina Ditrychova, Leigh A. Stoddart, Nicholas D. Holliday, Shane C. Wright, Volker M. Lauschke, Soren Nielsen, Camilla Scheele, Elizabeth Cheesman, Joris Hoeks, Peter Molenaar, Roger J. Summers, Benjamin Pelcman, Gopala K. Yakala, Tore Bengtsson
Publikováno v:
Molecular Metabolism, Vol 85, Iss , Pp 101931- (2024)
Objective: Simultaneous activation of β2- and β3-adrenoceptors (ARs) improves whole-body metabolism via beneficial effects in skeletal muscle and brown adipose tissue (BAT). Nevertheless, high-efficacy agonists simultaneously targeting these recept
Externí odkaz:
https://doaj.org/article/3d4a3a5490234ea7a397025d54414624
Autor:
Maria Augusta Arruda, Leigh A. Stoddart, Karolina Gherbi, Stephen J. Briddon, Barrie Kellam, Stephen J. Hill
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Recent advances in fluorescent ligand technology have enabled the study of G protein-coupled receptors in their native environment without the need for genetic modification such as addition of N-terminal fluorescent or bioluminescent tags. Here, we h
Externí odkaz:
https://doaj.org/article/a982dff703144b3f8a179f1e9b559184
Autor:
Sebastian Dekkers, Birgit Caspar, Joëlle Goulding, Nicholas D. Kindon, Laura E. Kilpatrick, Leigh A. Stoddart, Stephen J. Briddon, Barrie Kellam, Stephen J. Hill, Michael J. Stocks
Publikováno v:
Journal of Medicinal Chemistry. 66:5208-5222
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b89cd26eb4c4320286aeef5ab7453f1c
https://doi.org/10.1021/acs.jmedchem.3c00151
https://doi.org/10.1021/acs.jmedchem.3c00151
Autor:
Zhi Yuan, Kok, Leigh A, Stoddart, Sarah J, Mistry, Tamara A M, Mocking, Henry F, Vischer, Rob, Leurs, Stephen J, Hill, Shailesh N, Mistry, Barrie, Kellam
Publikováno v:
Journal of medicinal chemistry. 65(12)
The histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7280e0a0c9c4e28233b053dc813a0673
https://pubmed.ncbi.nlm.nih.gov/35734860
https://pubmed.ncbi.nlm.nih.gov/35734860
Autor:
Anh Nguyen, Stephen J. Hill, Eleonora Comeo, Peter J. Scammells, Leigh A. Stoddart, Michelle L. Halls, Nicholas D Kindon, Mark Soave, Cameron J. Nowell, Barrie Kellam, Jonathan M. White, Phuc N. H. Trinh, Lauren T. May
Publikováno v:
Journal of Medicinal Chemistry. 64:6670-6695
The adenosine A1 receptor (A1AR) is a G-protein-coupled receptor (GPCR) that provides important therapeutic opportunities for a number of conditions including congestive heart failure, tachycardia, and neuropathic pain. The development of A1AR-select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::943d2ba5ca01da830c950a86cefcf592
https://doi.org/10.1021/acs.jmedchem.0c02067
https://doi.org/10.1021/acs.jmedchem.0c02067
Autor:
Mark Soave, Laura E. Kilpatrick, Stephen J. Hill, Joelle Goulding, Leigh A. Stoddart, Carl W. White, Stephen J. Briddon
Publikováno v:
The Febs Journal
G protein‐coupled receptors (GPCRs) are the largest family of membrane receptors and major targets for FDA‐approved drugs. The ability to quantify GPCR expression and ligand binding characteristics in different cell types and tissues is therefore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4bcfa6da43077b77ca345698a1f3dc8
https://doi.org/10.1111/febs.15729
https://doi.org/10.1111/febs.15729
Publikováno v:
Br J Pharmacol
In recent years, several novel aspects of GPCR pharmacology have been described, which are thought to play a role in determining the in vivo efficacy of a compound. Fluorescent ligands have been used to study many of these, which have also required t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3fd83d36c5f9a0f3c1d0c89ddc0cc2
https://doi.org/10.1111/bph.14953
https://doi.org/10.1111/bph.14953
Autor:
Romez Uddin, Mark Wheatley, Stephen J. Hill, Stephen J. Briddon, Leigh A. Stoddart, Joelle Goulding, David R. Poyner, Rachael L. Grime
Publikováno v:
Nanoscale. 12:11518-11525
The fundamental importance of membrane proteins in cellular processes has driven a marked increase in the use of membrane mimetic approaches for studying and exploiting these proteins. Nano-encapsulation strategies which preserve the native lipid bil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c562d9b2668337cd6112eea7a6926555
https://doi.org/10.1039/d0nr01060j
https://doi.org/10.1039/d0nr01060j
Autor:
Stephen J. Hill, Leigh A. Stoddart, Peter J. Scammells, Eleonora Comeo, Laura E. Kilpatrick, Mark Soave, Nicholas D Kindon, Barrie Kellam
Publikováno v:
Journal of Medicinal Chemistry. 63:2656-2672
Among class A G protein-coupled receptors (GPCR), the human adenosine A2A receptor (hA2AAR) remains an attractive drug target. However, translation of A2AAR ligands into the clinic has proved chall...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8416a4d002aa32fbdef7bc13f40e6483
https://doi.org/10.1021/acs.jmedchem.9b01856
https://doi.org/10.1021/acs.jmedchem.9b01856
Publikováno v:
The international journal of biochemistrycell biology. 146
Fluorescence correlation spectroscopy (FCS) is a quantitative spectroscopy technique which could potentially increase throughput and sensitivity of screening for ligand, substrate and inhibitor binding to membrane proteins in solution. However, the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98015b1f3768c86664c4e90ee5cf3ac1
https://pubmed.ncbi.nlm.nih.gov/35390493
https://pubmed.ncbi.nlm.nih.gov/35390493