Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Leigh A. Jania"'
Autor:
John N Snouwaert, Leigh A Jania, Trang Nguyen, David R Martinez, Alexandra Schäfer, Nicholas J Catanzaro, Kendra L Gully, Ralph S Baric, Mark Heise, Martin T Ferris, Elizabeth Anderson, Katia Pressey, Jacob A Dillard, Sharon Taft-Benz, Victoria K Baxter, Jenny P-Y Ting, Beverly H Koller
Publikováno v:
PLoS Pathogens, Vol 19, Iss 2, p e1011168 (2023)
Angiotensin-converting enzyme 2 (ACE2), part of the renin-angiotensin system (RAS), serves as an entry point for SARS-CoV-2, leading to viral proliferation in permissive cell types. Using mouse lines in which the Ace2 locus has been humanized by synt
Externí odkaz:
https://doaj.org/article/75be0b479d294111a5b725cdfbedb42c
Autor:
Kelsey A Behrens, Leigh A Jania, John N Snouwaert, MyTrang Nguyen, Sheryl S Moy, Andrey P Tikunov, Jeffrey M Macdonald, Beverly H Koller
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225449 (2019)
Environmental and endogenous electrophiles cause tissue damage through their high reactivity with endogenous nucleophiles such as DNA, proteins, and lipids. Protection against damage is mediated by glutathione (GSH) conjugation, which can occur spont
Externí odkaz:
https://doaj.org/article/3bfefc70a31c4aed8966846980f44286
Autor:
Beverly H, Koller, John N, Snouwaert, Christelle, Douillet, Leigh A, Jania, Hisham, El-Masri, David J, Thomas, Miroslav, Stýblo
Publikováno v:
Environmental Health Perspectives
Chronic exposure to inorganic arsenic (iAs) is a significant public health problem. Methylation of iAs by arsenic methyltransferase (AS3MT) controls iAs detoxification and modifies risks of iAs-induced diseases. Mechanisms underlying these diseases h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84f12148974255887dea82fe737434fe
https://pubmed.ncbi.nlm.nih.gov/33054428
https://pubmed.ncbi.nlm.nih.gov/33054428
Autor:
John N. Snouwaert, Miroslav Stýblo, Beverly H. Koller, David J. Thomas, Christelle Douillet, Leigh A. Jania, Hisham A. El-Masri
Publikováno v:
Environmental Health Perspectives. 128
Background: Chronic exposure to inorganic arsenic (iAs) is a significant public health problem. Methylation of iAs by arsenic methyltransferase (AS3MT) controls iAs detoxification and modifies risk...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a489b20dcbf050140f5ffc6c9fa06b40
https://doi.org/10.1289/ehp6943
https://doi.org/10.1289/ehp6943
Autor:
Beverly H. Koller, Christian Melander, Roberta J. Melander, Leigh A. Jania, William T. Barker
Publikováno v:
Chem Biol Drug Des
The mounting threat of multi-drug-resistant (MDR) bacteria places a tremendous strain on the antimicrobial clinical arsenal, forcing physicians to revert to near-obsolete antibiotics to treat otherwise intractable infections. Antibiotic adjuvant ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d9d82bef3234920bf6bd6e11c4ed4b
https://pubmed.ncbi.nlm.nih.gov/32562384
https://pubmed.ncbi.nlm.nih.gov/32562384
Autor:
Christian Melander, Akash Basak, Tyler A. Hendricks, Leigh A. Jania, Patrick M. O'Connor, Santiana A. Marrujo, William T. Barker, Roberta J. Melander, Beverly H. Koller, Ansley M Nemeth, Ashley E. Sullivan, Alexander W. Weig
Publikováno v:
ChemMedChem
Infections caused by multi-drug resistant (MDR) bacteria, particularly Gram-negative bacteria, are an escalating global health threat. Often clinicians are forced to administer the last resort antibiotic colistin, however colistin resistance is becom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514bab61b6d0093a10fe6b352dc148ab
https://pubmed.ncbi.nlm.nih.gov/31756025
https://pubmed.ncbi.nlm.nih.gov/31756025
Autor:
Sara M Brackett, William T. Barker, Robert K. Ernst, Courtney E. Chandler, Ansley M Nemeth, Akash Basak, Beverly H. Koller, Christian Melander, Roberta J. Melander, William J. Zuercher, Leigh A. Jania
Publikováno v:
ACS Infect Dis
Kinase inhibitors comprise a diverse cohort of chemical scaffolds that are active in multiple biological systems. Currently, thousands of eukaryotic kinase inhibitors are commercially available, have well-characterized targets, and often carry pharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d295f6b49242c0c0a1a0f946e8dfb2
https://pubmed.ncbi.nlm.nih.gov/31434474
https://pubmed.ncbi.nlm.nih.gov/31434474
Autor:
Roberta J. Melander, Christian Melander, Bradley M. Minrovic, Leigh A. Jania, Veronica B Hubble, Beverly H. Koller, William T. Barker
Publikováno v:
ACS Med Chem Lett
[Image: see text] Antibiotic resistance has significantly increased since the beginning of the 21st century. Currently, the polymyxin colistin is typically viewed as the antibiotic of last resort for the treatment of multidrug resistant Gram-negative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03dda8bfdd139e1b625ff6b1786b3cb4
https://pubmed.ncbi.nlm.nih.gov/31098007
https://pubmed.ncbi.nlm.nih.gov/31098007
Autor:
Sheryl S. Moy, MyTrang Nguyen, Beverly H. Koller, Kelsey A. Behrens, Leigh A. Jania, John N. Snouwaert, Jeffrey M. Macdonald, Andrey P. Tikunov
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225449 (2019)
PLoS ONE
PLoS ONE
Environmental and endogenous electrophiles cause tissue damage through their high reactivity with endogenous nucleophiles such as DNA, proteins, and lipids. Protection against damage is mediated by glutathione (GSH) conjugation, which can occur spont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6243cc0daad65a3ecac909614ab293c3
https://doaj.org/article/3bfefc70a31c4aed8966846980f44286
https://doaj.org/article/3bfefc70a31c4aed8966846980f44286
Autor:
John N. Snouwaert, Beverly H. Koller, Damaris N Lorenzo, Fernando Pardo-Manuel de Villena, Rachel J. Church, Matthew L. Wheeler, Leigh A. Jania, Andrew Saintsing, Diane Armao, Piotr A. Mieczkowski, Sheryl S. Moy, My Trang Nguyen
Publikováno v:
Cell reports. 24(5)
Summary Lysosomes play a critical role in maintenance of the integrity of neuronal function, and mutations in genes that contribute to lysosome formation, transport, and activity are associated with neurodegenerative disorders. Recently, the multisub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed3dcfab1212ac5d94457b88776e6b5
https://pubmed.ncbi.nlm.nih.gov/30185380
https://pubmed.ncbi.nlm.nih.gov/30185380