Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Leigh A Knodler"'
Autor:
TuShun R Powers, Amanda L Haeberle, Alexander V Predeus, Disa L Hammarlöf, Jennifer A Cundiff, Zeus Saldaña-Ahuactzi, Karsten Hokamp, Jay C D Hinton, Leigh A Knodler
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009280 (2021)
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a zoonotic pathogen that causes diarrheal disease in humans and animals. During salmonellosis, S. Typhimurium colonizes epithelial cells lining the gastrointestinal tract. S. Typhimurium has
Externí odkaz:
https://doaj.org/article/d46ce7a9e66b41289c85e263789bfe2f
Autor:
Shauna M Crowley, Xiao Han, Joannie M Allaire, Martin Stahl, Isabella Rauch, Leigh A Knodler, Bruce A Vallance
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008498 (2020)
We investigated the role of the inflammasome effector caspases-1 and -11 during Salmonella enterica serovar Typhimurium infection of murine intestinal epithelial cells (IECs). Salmonella burdens were significantly greater in the intestines of caspase
Externí odkaz:
https://doaj.org/article/038531766fc4486bbc499e93c5ab38da
Autor:
Nicole Lau, Amanda L Haeberle, Brittany J O'Keeffe, Eleanor A Latomanski, Jean Celli, Hayley J Newton, Leigh A Knodler
Publikováno v:
PLoS Pathogens, Vol 15, Iss 7, p e1007959 (2019)
The enteric bacterial pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium), utilizes two type III secretion systems (T3SSs) to invade host cells, survive and replicate intracellularly. T3SS1 and its dedicated effector proteins are requir
Externí odkaz:
https://doaj.org/article/3a7d4c4d4d01451db86a16ce68ffaa89
Autor:
Johanna R Elfenbein, Leigh A Knodler, Ernesto S Nakayasu, Charles Ansong, Heather M Brewer, Lydia Bogomolnaya, L Garry Adams, Michael McClelland, Joshua N Adkins, Helene L Andrews-Polymenis
Publikováno v:
PLoS Genetics, Vol 11, Iss 9, p e1005472 (2015)
Multicopy single-stranded DNAs (msDNAs) are hybrid RNA-DNA molecules encoded on retroelements called retrons and produced by the action of retron reverse transcriptases. Retrons are widespread in bacteria but the natural function of msDNA has remaine
Externí odkaz:
https://doaj.org/article/a87cb4883dcb46eb9a2a9d8158edb4c2
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84681 (2014)
Within mammalian cells, Salmonella enterica serovar Typhimurium (S. Typhimurium) inhabits a membrane-bound vacuole known as the Salmonella-containing vacuole (SCV). We have recently shown that wild type S. Typhimurium also colonizes the cytosol of ep
Externí odkaz:
https://doaj.org/article/60d71e5bd63a4eb68c15c5c3c3f361a0
Autor:
Sebenzile Myeni, Robert Child, Tony W Ng, John J Kupko, Tara D Wehrly, Stephen F Porcella, Leigh A Knodler, Jean Celli
Publikováno v:
PLoS Pathogens, Vol 9, Iss 8, p e1003556 (2013)
The intracellular pathogenic bacterium Brucella generates a replicative vacuole (rBCV) derived from the endoplasmic reticulum via subversion of the host cell secretory pathway. rBCV biogenesis requires the expression of the Type IV secretion system (
Externí odkaz:
https://doaj.org/article/34971f7e393b47f89c27fac22e30ea47
Autor:
Stacey D Gilk, Diane C Cockrell, Courtney Luterbach, Bryan Hansen, Leigh A Knodler, J Antonio Ibarra, Olivia Steele-Mortimer, Robert A Heinzen
Publikováno v:
PLoS Pathogens, Vol 9, Iss 1, p e1003107 (2013)
Reports implicating important roles for cholesterol and cholesterol-rich lipid rafts in host-pathogen interactions have largely employed sterol sequestering agents and biosynthesis inhibitors. Because the pleiotropic effects of these compounds can co
Externí odkaz:
https://doaj.org/article/58d2e455e4dc4a53adb01f82ccccfb9c
Autor:
Kendal G Cooper, Seth Winfree, Preeti Malik-Kale, Carrie Jolly, Robin Ireland, Leigh A Knodler, Olivia Steele-Mortimer
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22260 (2011)
Salmonella enterica uses effector proteins translocated by a Type III Secretion System to invade epithelial cells. One of the invasion-associated effectors, SopB, is an inositol phosphatase that mediates sustained activation of the pro-survival kinas
Externí odkaz:
https://doaj.org/article/6527c50a98b84dc9b8ee975490bb9765
Publikováno v:
Mol Microbiol
Anti-bacterial autophagy, known as xenophagy, is a host innate immune response that targets invading pathogens for degradation. Some intracellular bacteria, such as the enteric pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium), utilis
Publikováno v:
Molecular microbiology. 118(4)
Salmonella enterica spp. produce siderophores to bind iron with high affinity and can also use three xenosiderophores secreted by other microorganisms, ferrichrome, coprogen, and ferrioxamine. Here we focused on FoxA, a TonB-dependent transporter of