Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Leigh A Knodler"'
Autor:
Xiao Han, Joannie M. Allaire, Shauna M. Crowley, Jocelyn J. Chan, Kelly Lau, Conghao Zhang, Simon A. Hirota, Kirk Bergstrom, Leigh A. Knodler, Bruce A. Vallance
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
The host restricts Salmonella enterica serovar Typhimurium infection of the gut via inflammasome-dependent sloughing of infected epithelial cells. Here we determined that concurrent caspase 1/11-dependent release of the goblet cell-derived mucin, Muc
Externí odkaz:
https://doaj.org/article/6c6253954466475d80d23564be718074
Autor:
TuShun R Powers, Amanda L Haeberle, Alexander V Predeus, Disa L Hammarlöf, Jennifer A Cundiff, Zeus Saldaña-Ahuactzi, Karsten Hokamp, Jay C D Hinton, Leigh A Knodler
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009280 (2021)
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a zoonotic pathogen that causes diarrheal disease in humans and animals. During salmonellosis, S. Typhimurium colonizes epithelial cells lining the gastrointestinal tract. S. Typhimurium has
Externí odkaz:
https://doaj.org/article/d46ce7a9e66b41289c85e263789bfe2f
Autor:
Shauna M Crowley, Xiao Han, Joannie M Allaire, Martin Stahl, Isabella Rauch, Leigh A Knodler, Bruce A Vallance
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008498 (2020)
We investigated the role of the inflammasome effector caspases-1 and -11 during Salmonella enterica serovar Typhimurium infection of murine intestinal epithelial cells (IECs). Salmonella burdens were significantly greater in the intestines of caspase
Externí odkaz:
https://doaj.org/article/038531766fc4486bbc499e93c5ab38da
Autor:
Nicole Lau, Amanda L Haeberle, Brittany J O'Keeffe, Eleanor A Latomanski, Jean Celli, Hayley J Newton, Leigh A Knodler
Publikováno v:
PLoS Pathogens, Vol 15, Iss 7, p e1007959 (2019)
The enteric bacterial pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium), utilizes two type III secretion systems (T3SSs) to invade host cells, survive and replicate intracellularly. T3SS1 and its dedicated effector proteins are requir
Externí odkaz:
https://doaj.org/article/3a7d4c4d4d01451db86a16ce68ffaa89
Publikováno v:
Mol Microbiol
Anti-bacterial autophagy, known as xenophagy, is a host innate immune response that targets invading pathogens for degradation. Some intracellular bacteria, such as the enteric pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium), utilis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f35b6f413c13e5bf00877623af90dc
https://doi.org/10.1111/mmi.14858
https://doi.org/10.1111/mmi.14858
Publikováno v:
mBio, Vol 8, Iss 6 (2017)
ABSTRACT The Salmonella invasion-associated type III secretion system (T3SS1) is an essential virulence factor required for entry into nonphagocytic cells and consequent uptake into a Salmonella-containing vacuole (SCV). While Salmonella is typically
Externí odkaz:
https://doaj.org/article/5e44cf00874b4077b493aa768ad1bc31
Publikováno v:
Molecular microbiology. 118(4)
Salmonella enterica spp. produce siderophores to bind iron with high affinity and can also use three xenosiderophores secreted by other microorganisms, ferrichrome, coprogen, and ferrioxamine. Here we focused on FoxA, a TonB-dependent transporter of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47db0442bbb91588a0b1d51e12ee454
https://pubmed.ncbi.nlm.nih.gov/35970762
https://pubmed.ncbi.nlm.nih.gov/35970762
Autor:
Johanna R Elfenbein, Leigh A Knodler, Ernesto S Nakayasu, Charles Ansong, Heather M Brewer, Lydia Bogomolnaya, L Garry Adams, Michael McClelland, Joshua N Adkins, Helene L Andrews-Polymenis
Publikováno v:
PLoS Genetics, Vol 11, Iss 9, p e1005472 (2015)
Multicopy single-stranded DNAs (msDNAs) are hybrid RNA-DNA molecules encoded on retroelements called retrons and produced by the action of retron reverse transcriptases. Retrons are widespread in bacteria but the natural function of msDNA has remaine
Externí odkaz:
https://doaj.org/article/a87cb4883dcb46eb9a2a9d8158edb4c2
Autor:
Kelsey A. Binder, Elizabeth Borghesan, Erin P. Smith, Jean Celli, Sebenzile K. Myeni, Leigh A. Knodler
Publikováno v:
EMBO Journal, 40(19). WILEY
The EMBO Journal
The EMBO Journal
Remodeling of host cellular membrane transport pathways is a common pathogenic trait of many intracellular microbes that is essential to their intravacuolar life cycle and proliferation. The bacterium Brucella abortus generates a host endoplasmic ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c94e19d793ee9e4ab94c55c7ff998c
https://doi.org/10.15252/embj.2021107664
https://doi.org/10.15252/embj.2021107664
Autor:
Joel Selkrig, Klemens Rottner, Olivia Steele-Mortimer, Cristina Viéitez, Leigh A. Knodler, Matthias Geyer, David W. Holden, Karoline Scholzen, Mikhail M. Savitski, Clement M. Potel, Keith C. Fernandez, Philipp Walch, Mandy Rettel, Frank Stein, Athanasios Typas
Publikováno v:
Cell host & microbe
United States
Cell Host Microbe
United States
Cell Host Microbe
SummaryIntracellular bacterial pathogens inject effector proteins into host cells to hijack diverse cellular processes and promote their survival and proliferation. To systematically map effector-host protein-protein interactions (PPIs) during infect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16df6f934d7f95802992b12a3031d53f
https://hdl.handle.net/10033/622977
https://hdl.handle.net/10033/622977
