Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Leigang Jin"'
Autor:
Xiaoping Wu, Lai Yee Cheong, Lufengzi Yuan, Leigang Jin, Zixuan Zhang, Yang Xiao, Zhiguang Zhou, Aimin Xu, Ruby LC Hoo, Lingling Shu
Publikováno v:
Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024)
Abstract Type 1 diabetes (T1D) is a chronic disease characterized by self‐destruction of insulin‐producing pancreatic β cells by cytotoxic T cell activity. However, the pathogenic mechanism of T cell infiltration remains obscure. Recently, tissu
Externí odkaz:
https://doaj.org/article/2d1d40e92cea4a5db59baec244a2bdc8
Autor:
Zhe Huang, Hye Kyoung Sung, Xingqun Yan, Shiyu He, Leigang Jin, Qin Wang, Xuerui Wu, Henry H. Hsu, Angelica Pignalosa, Kathryn Crawford, Gary Sweeney, Aimin Xu
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 6, Pp n/a-n/a (2024)
Abstract Metabolic dysfunction‐associated steatohepatitis (MASH) is the severe form of non‐alcoholic fatty liver disease which has a high potential to progress to cirrhosis and hepatocellular carcinoma, yet adequate effective therapies are lackin
Externí odkaz:
https://doaj.org/article/c03d45ca6ff64906874b9a5986c035b2
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 3, Pp 432-444 (2024)
Abstract Regular exercise has both immediate and long-lasting benefits on cardiometabolic health, and has been recommended as a cornerstone of treatment in the management of diabetes and cardiovascular conditions. Exerkines, which are defined as humo
Externí odkaz:
https://doaj.org/article/102951de9141495e8f6183f9132940e5
Autor:
Lai Yee Cheong, Baile Wang, Qin Wang, Leigang Jin, Kelvin H. M. Kwok, Xiaoping Wu, Lingling Shu, Huige Lin, Sookja Kim Chung, Kenneth K. Y. Cheng, Ruby L. C. Hoo, Aimin Xu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Beiging and thermogenesis in white adipose tissue (WAT) is an important adaptive response to cold exposure, but how the brain senses cold and subsequently induces beiging remains unclear. Here, the authors show that sympathetic nerves stimulate lymph
Externí odkaz:
https://doaj.org/article/855172dea7104e12b8e6ff973eaba45e
Autor:
Kang Chen, Lai Yee Cheong, Yuan Gao, Yaming Zhang, Tianshi Feng, Qin Wang, Leigang Jin, Eric Honoré, Karen S. L. Lam, Weiping Wang, Xiaoyan Hui, Aimin Xu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Although thyroid hormone (TH) has anti-obesity potential, systemic administration of TH causes severe adverse effects without obvious weight loss. Here, the authors show that adipose tissue-targeted delivery of TH with liposomes is a safe and efficie
Externí odkaz:
https://doaj.org/article/a41188231e854b5bb69ffa79bdacf04d
Autor:
Yun-Tao Zhao, Haowen Yin, Chuanyin Hu, Jian Zeng, Shilin Zhang, Shaohong Chen, Wenjing Zheng, Mengjiao Li, Leigang Jin, You Liu, Wenjin Wu, Shucheng Liu
Publikováno v:
Frontiers in Nutrition, Vol 9 (2022)
Anxiety- and depression-like behavior following chemotherapy treatment occurs in cancer patients with high probability and no specific therapeutics are available for treatment and prevention of this complication. Here, tilapia skin peptides (TSP), a
Externí odkaz:
https://doaj.org/article/a9fa94d63a184ef49f60e53fec729895
Autor:
Leiluo Geng, Boya Liao, Leigang Jin, Zhe Huang, Chris R. Triggle, Hong Ding, Jialiang Zhang, Yu Huang, Zhuofeng Lin, Aimin Xu
Publikováno v:
Cell Reports, Vol 26, Iss 10, Pp 2738-2752.e4 (2019)
Summary: Exercise promotes adipose remodeling and improves obesity-induced metabolic disorders through mechanisms that remain obscure. Here, we identify the FGF21 signaling in adipose tissues as an obligatory molecular transducer of exercise conferri
Externí odkaz:
https://doaj.org/article/ef6f9a023b494ddab1778f292c0654e0
Publikováno v:
Diabetes & Metabolism Journal, Vol 40, Iss 1, Pp 22-31 (2016)
Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on energy metabolism and insulin sensitivity. Besides its antiobese and antidiabetic activity, FGF21 also possesses the protective effects against atherosclerosis. Ci
Externí odkaz:
https://doaj.org/article/6c48298940ad41919f5ed90b365a6fb4
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e94478 (2014)
BACKGROUND: Complement-C1q TNF-related protein 1 (CTRP1), a member of the CTRP superfamily, possesses anti-inflammatory and anti-diabetic effects in mice. However, the clinical relevance of CTRP1 has been seldom explored. The current study aimed to i
Externí odkaz:
https://doaj.org/article/0f27955186404209b304ad0548035d61
Autor:
Leping Zhao, Fan Wu, Leigang Jin, Tingting Lu, Lihui Yang, Xuebo Pan, Chuanfeng Shao, Xiaokun Li, Zhuofeng Lin
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87786 (2014)
BACKGROUND: Soluble C-X-C chemokine ligand 16 (CXCL16), a scavenger receptor for oxidized low density lipoprotein, has been shown to promote atherogenic effects in vivo and to predict long-term mortality in acute coronary syndrome. The aim of this st
Externí odkaz:
https://doaj.org/article/8791e372a68540a8b1a283c9c648f0b6