Type 2 diabetes and obesity induce similar transcriptional reprogramming in human myocytes

Autor: Leif Väremo, Tora Ida Henriksen, Camilla Scheele, Christa Broholm, Maria Pedersen, Mathias Uhlén, Bente Klarlund Pedersen, Jens Nielsen

Publikováno v: Genome Medicine, Vol 9, Iss 1, Pp 1-12 (2017)

Abstract Background Skeletal muscle is one of the primary tissues involved in the development of type 2 diabetes (T2D). The close association between obesity and T2D makes it difficult to isolate specific effects attributed to the disease alone. Ther

Externí odkaz: https://doaj.org/article/a3a7569f082e465e906b6429196810e6

Six Tissue Transcriptomics Reveals Specific Immune Suppression in Spleen by Dietary Polyunsaturated Fatty Acids.

Autor: Sara L Svahn, Leif Väremo, Britt G Gabrielsson, Eduard Peris, Intawat Nookaew, Louise Grahnemo, Ann-Sofie Sandberg, Ingrid Wernstedt Asterholm, John-Olov Jansson, Jens Nielsen, Maria E Johansson

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0155099 (2016)

Dietary polyunsaturated fatty acids (PUFA) are suggested to modulate immune function, but the effects of dietary fatty acids composition on gene expression patterns in immune organs have not been fully characterized. In the current study we investiga

Externí odkaz: https://doaj.org/article/31dcd3413e304c0cb68aa1d7777a400b

Metabolome dynamics of diapause in the butterfly

Autor: Philipp, Lehmann, Peter, Pruisscher, Vladimír, Koštál, Martin, Moos, Petr, Šimek, Sören, Nylin, Rasmus, Agren, Leif, Väremo, Christer, Wiklund, Christopher W, Wheat, Karl, Gotthard

Publikováno v: The Journal of experimental biology. 221(Pt 2)

Diapause is a deep resting stage facilitating temporal avoidance of unfavourable environmental conditions, and is used by many insects to adapt their life cycle to seasonal variation. Although considerable work has been invested in trying to understa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f514aa0d04b3357af9b8c82555d2de1
https://pubmed.ncbi.nlm.nih.gov/29180603

Type 2 diabetes and obesity induce similar transcriptional reprogramming in human myocytes

Autor: Bente Klarlund Pedersen, Mathias Uhlén, Christa Broholm, Tora Ida Henriksen, Leif Väremo, Camilla Scheele, Maria Pedersen, Jens Nielsen

Publikováno v: Väremo, L, Henriksen, T I, Scheele, C, Broholm, C, Pedersen, M, Uhlén, M, Pedersen, B K & Nielsen, J 2017, ' Type 2 diabetes and obesity induce similar transcriptional reprogramming in human myocytes ', Genome Medicine, vol. 9, 47 . https://doi.org/10.1186/s13073-017-0432-2
Genome Medicine, Vol 9, Iss 1, Pp 1-12 (2017)
Genome Medicine

Background Skeletal muscle is one of the primary tissues involved in the development of type 2 diabetes (T2D). The close association between obesity and T2D makes it difficult to isolate specific effects attributed to the disease alone. Therefore, he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d18f022a8c54499bbca2db60b6ea7843
https://curis.ku.dk/portal/da/publications/type-2-diabetes-and-obesity-induce-similar-transcriptional-reprogramming-in-human-myocytes(872f928f-ec92-4b43-a43f-32bbd44f33ca).html

BioMet Toolbox 2.0: genome-wide analysis of metabolism and omics data

Autor: Jens Nielsen, Manuel Garcia-Albornoz, Avlant Nilsson, Intawat Nookaew, Subazini Thankaswamy-Kosalai, Leif Väremo

Publikováno v: Nucleic Acids Research
Europe PubMed Central
Nucleic Acids Research (0305-1048) vol.42(2014)

Analysis of large data sets using computational and mathematical tools have become a central part of biological sciences. Large amounts of data are being generated each year from different biological research fields leading to a constant development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131f1514bc736d7fdfe0e4c5c7e41d64
https://doi.org/10.1093/nar/gku371