Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Leif S. Ludwig"'
Autor:
Laleh Haghverdi, Leif S. Ludwig
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 13-25 (2023)
Summary: The concept of cell fate relates to the future identity of a cell, and its daughters, which is obtained via cell differentiation and division. Understanding, predicting, and manipulating cell fate has been a long-sought goal of developmental
Externí odkaz:
https://doaj.org/article/53eecb7e73bb4e48b00b2e0385d558ae
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background Exogenous cDNA introduced into an experimental system, either intentionally or accidentally, can appear as added read coverage over that gene in next-generation sequencing libraries derived from this system. If not properly recogn
Externí odkaz:
https://doaj.org/article/e63abeda4c1d400b9d4b0c88a680ac57
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/8407a96a3e8543acad2e7e5aab34ec15
Autor:
John P. Ray, Carl G. de Boer, Charles P. Fulco, Caleb A. Lareau, Masahiro Kanai, Jacob C. Ulirsch, Ryan Tewhey, Leif S. Ludwig, Steven K. Reilly, Drew T. Bergman, Jesse M. Engreitz, Robbyn Issner, Hilary K. Finucane, Eric S. Lander, Aviv Regev, Nir Hacohen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
While genome-wide association studies have yielded thousands of trait-associated loci, identifying causal variants remains challenging. Here, the authors perform seven genomics assays in various cell types to prioritize genetic variants in the TNFAIP
Externí odkaz:
https://doaj.org/article/1ebe14a757924ee7b684604e682e0db0
Autor:
Leif S. Ludwig, Caleb A. Lareau, Erik L. Bao, Satish K. Nandakumar, Christoph Muus, Jacob C. Ulirsch, Kaitavjeet Chowdhary, Jason D. Buenrostro, Narla Mohandas, Xiuli An, Martin J. Aryee, Aviv Regev, Vijay G. Sankaran
Publikováno v:
Cell Reports, Vol 27, Iss 11, Pp 3228-3240.e7 (2019)
Summary: Human erythropoiesis serves as a paradigm of physiologic cellular differentiation. This process is also of considerable interest for better understanding anemias and identifying new therapies. Here, we apply deep transcriptomic and accessibl
Externí odkaz:
https://doaj.org/article/6398f2df4d4c4128b606c247249494a4
Autor:
Leif S. Ludwig, Laleh Haghverdi
Publikováno v:
Stem Cell Reports. 18:13-25
Publikováno v:
Nature Immunology. 23:1551-1563
Clonal expansion of cells with somatically diversified receptors and their long-term maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied pathogen-specific adaptation within the innate immune system, tracking natural kille
Autor:
Catherine J. Wu, Vijay G. Sankaran, Kenneth J. Livak, Donna S. Neuberg, Matthew S. Davids, Jennifer R. Brown, Thomas J. Kipps, Laura Z. Rassenti, Gad Getz, Laxmi Parida, Ignaty Leshchiner, Dimitri Livitz, Wandi Zhang, Shuqiang Li, Teddy Huang, Erin M. Parry, Leif S. Ludwig, Caleb Lareau, Satyen H. Gohil, Livius Penter
Supplementary methods, Table S1, supplementary figures 1-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d52d9b72b2b9e5d0415753d8671c867
https://doi.org/10.1158/2159-8290.22540460
https://doi.org/10.1158/2159-8290.22540460
Autor:
Catherine J. Wu, Vijay G. Sankaran, Kenneth J. Livak, Donna S. Neuberg, Matthew S. Davids, Jennifer R. Brown, Thomas J. Kipps, Laura Z. Rassenti, Gad Getz, Laxmi Parida, Ignaty Leshchiner, Dimitri Livitz, Wandi Zhang, Shuqiang Li, Teddy Huang, Erin M. Parry, Leif S. Ludwig, Caleb Lareau, Satyen H. Gohil, Livius Penter
While cancers evolve during disease progression and in response to therapy, temporal dynamics remain difficult to study in humans due to the lack of consistent barcodes marking individual clones in vivo. We employ mitochondrial single-cell assay for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86139f03544b393591f7c2c3283b6642
https://doi.org/10.1158/2159-8290.c.6549383.v1
https://doi.org/10.1158/2159-8290.c.6549383.v1
Autor:
Catherine J. Wu, Vijay G. Sankaran, Kenneth J. Livak, Donna S. Neuberg, Matthew S. Davids, Jennifer R. Brown, Thomas J. Kipps, Laura Z. Rassenti, Gad Getz, Laxmi Parida, Ignaty Leshchiner, Dimitri Livitz, Wandi Zhang, Shuqiang Li, Teddy Huang, Erin M. Parry, Leif S. Ludwig, Caleb Lareau, Satyen H. Gohil, Livius Penter
Supplementary Table 2 - %CLL cells marked by mtDNA mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01087b1fa6a13288b212d154de9e3e44
https://doi.org/10.1158/2159-8290.22540457
https://doi.org/10.1158/2159-8290.22540457