Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Leif S, Ludwig"'
Autor:
Laleh Haghverdi, Leif S. Ludwig
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 13-25 (2023)
Summary: The concept of cell fate relates to the future identity of a cell, and its daughters, which is obtained via cell differentiation and division. Understanding, predicting, and manipulating cell fate has been a long-sought goal of developmental
Externí odkaz:
https://doaj.org/article/53eecb7e73bb4e48b00b2e0385d558ae
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background Exogenous cDNA introduced into an experimental system, either intentionally or accidentally, can appear as added read coverage over that gene in next-generation sequencing libraries derived from this system. If not properly recogn
Externí odkaz:
https://doaj.org/article/e63abeda4c1d400b9d4b0c88a680ac57
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/8407a96a3e8543acad2e7e5aab34ec15
Autor:
John P. Ray, Carl G. de Boer, Charles P. Fulco, Caleb A. Lareau, Masahiro Kanai, Jacob C. Ulirsch, Ryan Tewhey, Leif S. Ludwig, Steven K. Reilly, Drew T. Bergman, Jesse M. Engreitz, Robbyn Issner, Hilary K. Finucane, Eric S. Lander, Aviv Regev, Nir Hacohen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
While genome-wide association studies have yielded thousands of trait-associated loci, identifying causal variants remains challenging. Here, the authors perform seven genomics assays in various cell types to prioritize genetic variants in the TNFAIP
Externí odkaz:
https://doaj.org/article/1ebe14a757924ee7b684604e682e0db0
Publikováno v:
Blood Advances, Vol 3, Iss 24, Pp 4161-4165 (2019)
Abstract: Our ability to track cellular dynamics in humans over time in vivo has been limited. Here, we demonstrate how somatic mutations in mitochondrial DNA (mtDNA) can be used to longitudinally track the dynamic output of hematopoietic stem and pr
Externí odkaz:
https://doaj.org/article/fd9f1c9dac164f5bab902e1cc11c0d62
Autor:
Leif S. Ludwig, Laleh Haghverdi
Publikováno v:
Stem Cell Reports. 18:13-25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93ced5512c26269d0c290a2f0119b79b
https://doi.org/10.1016/j.stemcr.2022.12.003
https://doi.org/10.1016/j.stemcr.2022.12.003
Publikováno v:
Nature Immunology. 23:1551-1563
Clonal expansion of cells with somatically diversified receptors and their long-term maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied pathogen-specific adaptation within the innate immune system, tracking natural kille
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a65ad7aa0d1a7b9682969c00d554ad
https://doi.org/10.1038/s41590-022-01327-7
https://doi.org/10.1038/s41590-022-01327-7
Autor:
Leif S. Ludwig, Caleb A. Lareau, Erik L. Bao, Satish K. Nandakumar, Christoph Muus, Jacob C. Ulirsch, Kaitavjeet Chowdhary, Jason D. Buenrostro, Narla Mohandas, Xiuli An, Martin J. Aryee, Aviv Regev, Vijay G. Sankaran
Publikováno v:
Cell Reports, Vol 27, Iss 11, Pp 3228-3240.e7 (2019)
Summary: Human erythropoiesis serves as a paradigm of physiologic cellular differentiation. This process is also of considerable interest for better understanding anemias and identifying new therapies. Here, we apply deep transcriptomic and accessibl
Externí odkaz:
https://doaj.org/article/6398f2df4d4c4128b606c247249494a4
Autor:
Satish K Nandakumar, Sean K McFarland, Laura M Mateyka, Caleb A Lareau, Jacob C Ulirsch, Leif S Ludwig, Gaurav Agarwal, Jesse M Engreitz, Bartlomiej Przychodzen, Marie McConkey, Glenn S Cowley, John G Doench, Jaroslaw P Maciejewski, Benjamin L Ebert, David E Root, Vijay G Sankaran
Publikováno v:
eLife, Vol 8 (2019)
Genome-wide association studies (GWAS) have identified thousands of variants associated with human diseases and traits. However, the majority of GWAS-implicated variants are in non-coding regions of the genome and require in depth follow-up to identi
Externí odkaz:
https://doaj.org/article/09881636b6d7446194ad63718568b54a
Autor:
Catherine J. Wu, Vijay G. Sankaran, Kenneth J. Livak, Donna S. Neuberg, Matthew S. Davids, Jennifer R. Brown, Thomas J. Kipps, Laura Z. Rassenti, Gad Getz, Laxmi Parida, Ignaty Leshchiner, Dimitri Livitz, Wandi Zhang, Shuqiang Li, Teddy Huang, Erin M. Parry, Leif S. Ludwig, Caleb Lareau, Satyen H. Gohil, Livius Penter
Supplementary methods, Table S1, supplementary figures 1-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d52d9b72b2b9e5d0415753d8671c867
https://doi.org/10.1158/2159-8290.22540460
https://doi.org/10.1158/2159-8290.22540460
