Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Leif Nørskov-Lauritsen"'
Autor:
Peter Thygesen, Charlotta G. Folkesson, Charlotte Wiberg, Henrik S. Ramírez-Andersen, Mats Reslow, Jens Buchardt, Per Franklin Nielsen, Xin Zhao, Nils Langeland Johansen, Johannes Josef Fels, Chen Jianhe, Leif Nørskov-Lauritsen, Christian Rischel, Xia Wenjuan, Jing Su, Carsten Behrens
Publikováno v:
Bioconjugate Chemistry. 29:3129-3143
The present work describes a series of human growth hormone (hGH) albumin binder conjugates with an extended in vivo half-life. A broad range of different conjugates were studied by varying the albumin binder structure and conjugation site. Conjugate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82348c015bc30de66842f2cd5ec1fd9
https://doi.org/10.1021/acs.bioconjchem.8b00463
https://doi.org/10.1021/acs.bioconjchem.8b00463
Autor:
Christian Rischel, Henrik Sune Andersen, Johannes Josef Fels, Leif Nørskov-Lauritsen, Nils Langeland Johansen, Carsten Behrens, Peter Thygesen
Publikováno v:
Growth hormoneIGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 35
Somapacitan is an albumin-binding growth hormone derivative intended for once weekly administration, currently in clinical development for treatment of adult as well as juvenile GH deficiency. Nonclinical in vivo pharmacological characterisation of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33145513196dfaf7048536431e7ccd55
https://pubmed.ncbi.nlm.nih.gov/28595133
https://pubmed.ncbi.nlm.nih.gov/28595133
Autor:
Gunnar Houen, Phaedria M. St. Hilaire, Martin Lund, Leif Nørskov-Lauritsen, N. Johan V. Lindgren, Per-Erik Gustavsson, Roice Michael, Line Naomi Lund, Arne Staby
Publikováno v:
Lund, L N, Gustavsson, P E, Michael, R, Lindgren, J, Norskov-Lauritsen, L, Lund, M, Houen, G, Staby, A & St Hilaire, P M 2012, ' Novel peptide ligand with high binding capacity for antibody purification ', Journal of Chromatography A, vol. 1225, pp. 158-167 . https://doi.org/10.1016/j.chroma.2011.12.074
Small synthetic ligands for protein purification have become increasingly interesting with the growing need for cheap chromatographic materials for protein purification and especially for the purification of monoclonal antibodies (mAbs). Today, Prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d356e9bc8cef7e9490a8df0e43f3d7
https://doi.org/10.1016/j.chroma.2011.12.074
https://doi.org/10.1016/j.chroma.2011.12.074
Autor:
Jinchao Zhang, Yun Liu, Sean Hu, Jens Breinholt, Wei Guo, Leif Christensen, Tengkun Li, Jingyuan Zhang, Jingjing Mao, Wei Gong, Jianhe Chen, Svetlana Panina, Lingyun Wang, Leif Nørskov-Lauritsen, Meng Kong, Zibing Liu, Qinhong Ma
Publikováno v:
Protein Engineering Design and Selection. 24:855-860
Prolactin (PRL), a potent growth stimulator of the mammary epithelium, has been suggested to be a factor contributing to the development and progression of breast and prostate cancer. Several PRL receptor (PRLR) antagonists have been identified in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39455ac8ff4d26b1133903d256bdfef4
https://doi.org/10.1093/protein/gzr047
https://doi.org/10.1093/protein/gzr047
Autor:
Jakob E. Rasmussen, Christine B. Schiødt, Søren F. Christensen, Leif Nørskov-Lauritsen, Morten Meldal, Phaedria M. St. Hilaire, Knud J. Jensen
Publikováno v:
Angewandte Chemie. 122:3555-3558
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d313a2ab9941a27547ceac6199d81331
https://doi.org/10.1002/ange.200906602
https://doi.org/10.1002/ange.200906602
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1525-1528
Using a virtual screening strategy based on a methodology derived from the CATS molecular descriptor, a novel compound class with inhibitory activity against the GSK-3 enzyme was identified through scaffold hopping. These compounds were readily synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a25ebd2eeb1f42f4f7e352f2d246538
https://doi.org/10.1016/s0960-894x(02)00169-5
https://doi.org/10.1016/s0960-894x(02)00169-5
Autor:
Leif Nørskov-Lauritsen, Jakob E. Rasmussen, Soren Christensen, Phaedria M. St. Hilaire, Knud J. Jensen, Christine Bruun Schiødt, Morten Meldal
Publikováno v:
Angewandte Chemie (International ed. in English). 49(20)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09f3f3549f7a9e05b2268161f4224e8
https://pubmed.ncbi.nlm.nih.gov/20301150
https://pubmed.ncbi.nlm.nih.gov/20301150
Autor:
Nikos G. Oikonomakos, Marit Kristiansen, Leif Nørskov-Lauritsen, Loranne Agius, C. Tiraidis, Claus U. Jessen, Demetres D. Leonidas, Spyros E. Zographos
Publikováno v:
Journal of Medicinal Chemistry 49:19(Sep2006):5687-5701
Iminosugars DAB (5), isofagomine (9), and several N-substituted derivatives have been identified as potent inhibitors of liver glycogen phosphorylase a (IC(50) = 0.4-1.2 microM) and of basal and glucagon-stimulated glycogenolysis (IC(50) = 1-3 microM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6825eb06d94aec99a3f6b46470f41cb4
http://helios-eie.ekt.gr/EIE/handle/10442/7969
http://helios-eie.ekt.gr/EIE/handle/10442/7969
Autor:
Kent Bondensgaard, Leif Nørskov-Lauritsen, Peter Becker, Kasper D. Rand, L. Anders Svensson, Jens Breinholt, Morten Jonas Maltesen, Mette Dahl Andersen, Leif Christensen
Publikováno v:
The Journal of biological chemistry. 283(27)
The crystal structure of the complex between an N-terminally truncated G129R human prolactin (PRL) variant and the extracellular domain of the human prolactin receptor (PRLR) was determined at 2.5A resolution by x-ray crystallography. This structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2730b724aaf25284719e6715fbcb7f
https://pubmed.ncbi.nlm.nih.gov/18467331
https://pubmed.ncbi.nlm.nih.gov/18467331
Publikováno v:
Tetrahedron. 37:3671-3679
The photoelectron (PE) spectrum of cis-1,4,5,8-tetraoxadecalin exhibits in contrast to most polyoxa compounds an extremely well resolved low energy pan due to large ‘through-bond’ interactions between the oxygen lone pairs and the ideally oriente
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::599f201e2ee58a68e5b24de877239d67
https://doi.org/10.1016/s0040-4020(01)98897-0
https://doi.org/10.1016/s0040-4020(01)98897-0