Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Leif Kongskov Larsen"'
Autor:
Henrik H. Hansen, Rikke V. Grønlund, Tamara Baader-Pagler, Peter Haebel, Harald Tammen, Leif Kongskov Larsen, Jacob Jelsing, Niels Vrang, Thomas Klein
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Dipeptidyl peptidase IV (DPP-IV) inhibitors improve glycemic control by prolonging the action of glucagon-like peptide-1 (GLP-1). In contrast to GLP-1 analogues, DPP-IV inhibitors are weight-neutral. DPP-IV cleavage of PYY and NPY gives rise
Externí odkaz:
https://doaj.org/article/97a3ac05b965484c814efcbeef1dbf0b
Autor:
Sarah Juel Paulsen, Leif Kongskov Larsen, Gitte Hansen, Shekar Chelur, Philip Just Larsen, Niels Vrang
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88227 (2014)
Stimulation of the G protein coupled receptor GPR120 has been shown to have anti-inflammatory and insulin-sensitizing effects, to promote glucagon like peptide-1 (GLP-1) secretion, and to play a key role in sensing dietary fat and control energy bala
Externí odkaz:
https://doaj.org/article/27b213cc4d2845e2b6f2ee9334ff1d51
Publikováno v:
Journal of Anatomy. 217:624-630
The present study was initiated to improve our understanding of pancreatic beta-cell dynamics in male Zucker Diabetic Fatty (ZDF) rats and hence provide a framework for future diabetes studies in this animal model. Male ZDF rats from 6, 8, 10, 12, 14
Characterization of β-Cell Mass and Insulin Resistance in Diet-induced Obese and Diet-resistant Rats
Autor:
Kirsten Lykkegaard, Jacob Jelsing, Philip J. Larsen, Barry E. Levin, Andreas N. Madsen, Sarah Juel Paulsen, Leif Kongskov Larsen, Gitte Hansen, Niels Vrang
Publikováno v:
Obesity. 18:266-273
The selectively bred diet-induced obese (DIO) and diet-resistant (DR) rats represent a polygenetic animal model mimicking most clinical variables characterizing the human metabolic syndrome. When fed a high-energy (HE) diet DIO rats develop visceral
Autor:
Jacob Jelsing, Niels Vrang, Uwe Jansen, Sarah Juel Paulsen, Leif Kongskov Larsen, Bernhard Gerstmayer
Publikováno v:
Journal of Neuroscience Methods. 177:87-93
In order to identify novel genes involved in appetite and body weight regulation we have developed a microarray based method suitable for detecting small changes in gene expression in discrete groups of hypothalamic neurons. The method is based on a
Autor:
Per Sauerberg, Philip J. Larsen, Kirsten Lykkegaard, Karsten Wassermann, Erik M. Wulff, Jan Fleckner, Leif Kongskov Larsen
Publikováno v:
European Journal of Pharmacology. 596:173-179
Balaglitazone is a novel thiazolidinedione in clinical development for the treatment of type 2 diabetes. Common side effects associated with PPARgamma receptor agonists are weight gain, oedema and adipogenesis. Balaglitazone is a selective partial PP
Autor:
Peter Lommer Kristensen, Mads Tang-Christensen, Philip J. Larsen, Niels Vrang, Leif Kongskov Larsen
Publikováno v:
Brain Research. 965:45-50
Cocaine-amphetamine-regulated transcript (CART) is one of the most abundantly expressed mRNAs in the rat hypothalamus. CART mRNA expression in the arcuate nucleus has been shown to be regulated by leptin, and CART peptides have been implicated in fee
Autor:
Sarah Juel, Paulsen, Niels, Vrang, Leif Kongskov, Larsen, Philip Just, Larsen, Jacob, Jelsing
Publikováno v:
Journal of anatomy. 217(5)
The present study was initiated to improve our understanding of pancreatic beta-cell dynamics in male Zucker Diabetic Fatty (ZDF) rats and hence provide a framework for future diabetes studies in this animal model. Male ZDF rats from 6, 8, 10, 12, 14
Autor:
Morten A. Karsdal, Natasha Barascuk, R. Xing, Lars Melholt Rasmussen, Leif Kongskov Larsen, Yongsheng Cao, Dorthe Vang Larsen, Qiuju Zheng, Martin R. Larsen, Sanne Skovgård Veidal, J. Wang
Publikováno v:
Barascuk, N, Veidal, S S, Larsen, L, Larsen, D V, Larsen, M R, Wang, J, Zheng, Q, Xing, R, Cao, Y, Rasmussen, L M & Karsdal, M A 2010, ' A novel assay for extracellular matrix remodeling associated with liver fibrosis : An enzyme-linked immunosorbent assay (ELISA) for a MMP-9 proteolytically revealed neo-epitope of type III collagen ', Developments in Clinical Biochemistry, vol. 43, no. 10-11, pp. 899-904 . https://doi.org/10.1016/j.clinbiochem.2010.03.012
Accumulation of extracellular matrix (ECM) components and increased matrix-metalloprotease (MMPs) activity are hallmarks of fibrosis. We developed an ELISA for quantification of MMP-9 derived collagen type III (CO3) degradation.A monoclonal antibody
Autor:
P. Froguel, Yong Jun Liu, Kenneth Thirstrup, Leif Kongskov Larsen, Vincent Vatin, Lena M. S. Carlsson, Per Jacobson, Jens D. Mikkelsen, Hong-Wen Deng, Philip J. Larsen, Karina B. Cullberg, Mads Tang-Christensen, Jan Fahrenkrug, Niels Vrang, Lars Sjöström, Xiao-Gang Liu, David Meyre, Jacob Jelsing
Using restriction fragment differential display (RFDD) technology, we have identified the imprinted gene neuronatin (Nnat) as a hypothalamic target under the influence of leptin. Nnat mRNA expression is decreased in several key appetite regulatory hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2322079691b17ec62c9ca56b2147d3
https://europepmc.org/articles/PMC2921166/
https://europepmc.org/articles/PMC2921166/