Výsledky vyhledávání - "Leif K. Larsen"

Characterization of combined linagliptin and Y2R agonist treatment in diet-induced obese mice

Autor: Leif K. Larsen, Henrik H. Hansen, Jacob Jelsing, Harald Tammen, Niels Vrang, Peter W. Haebel, Rikke V. Grônlund, Thomas Klein, Tamara Baader-Pagler

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Dipeptidyl peptidase IV (DPP-IV) inhibitors improve glycemic control by prolonging the action of glucagon-like peptide-1 (GLP-1). In contrast to GLP-1 analogues, DPP-IV inhibitors are weight-neutral. DPP-IV cleavage of PYY and NPY gives rise to PYY3-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120fa05ea99ec2378256ffe043c674e3
https://pubmed.ncbi.nlm.nih.gov/33850212

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Insulin-like Growth Factor-1/Insulin Bypasses Pref-1/FA1-mediated Inhibition of Adipocyte Differentiation

Autor: Charlotte Harken Jensen, Hongbin Zhang, Leif K. Larsen, Susanne Mandrup, Børge Teisner, Elin Bachmann, Rasmus Koefoed Petersen, Jane Nøhr, Karsten Kristiansen

Publikováno v: Zhang, H, Nøhr, J, Jensen, C H, Petersen, R K, Bachmann, E, Teisner, B, Larsen, L K, Mandrup, S & Kristiansen, K 2003, ' Insulin like growth factor-1/insulin bypasses Pref-1/FA1-mediated inhibition of adipocyte differentiation ', Journal of Biological Chemistry, vol. 278, no. 23, pp. 20906-14 . https://doi.org/10.1074/jbc.M300022200

Pref-1 is a highly glycosylated Delta-like transmembrane protein containing six epidermal growth factor-like repeats in the extracellular domain. Pref-1 is abundantly expressed in preadipocytes, but expression is down-regulated during adipocyte diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e392914662b636723e55afbd65ca691
https://doi.org/10.1074/jbc.m300022200

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Genomic organization of the mouse peroxisome proliferator-activated receptor β/δ gene: alternative promoter usage and splicing yield transcripts exhibiting differential translational efficiency

Autor: Ez-Zoubir Amri, Leif K. Larsen, Karsten Kristiansen, Corinne Pacot, Susanne Mandrup

Publikováno v: Biochemical Journal. 366:767-775

Peroxisome proliferator-activated receptor (PPAR) beta/delta is ubiquitously expressed, but the level of expression differs markedly between different cell types. In order to determine the molecular mechanisms governing PPARbeta/delta gene expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c09c2fd45946bce234261475f45339
https://doi.org/10.1042/bj20011821

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The gene encoding the Acyl-CoA-binding protein is activated by peroxisome proliferator-activated receptor gamma through an intronic response element functionally conserved between humans and rodents

Autor: Susanne Mandrup, Leif K. Larsen, Maria Sandberg Boysen, Jane Nøhr, Søren Sindberg Jensen, Tatjana Albrektsen, Pia Kiilerich, Karsten Kristiansen, Luc E. G. Rietveld, Lars Grøntved, Jan Fleckner, Hendrik G. Stunnenberg, Torben Helledie

Publikováno v: Journal of Biological Chemistry, 277, 26821-26830
Journal of Biological Chemistry, 277, 30, pp. 26821-26830
Helledie, T, Grøntved, L, Jensen, S S, Kiilerich, P, Rietveld, L, Albrektsen, T, Boysen, M S, Nøhr, J, Larsen, L K, Fleckner, J, Stunnenberg, H G, Kristiansen, K & Mandrup, S 2002, ' The gene encoding the Acyl-CoA-binding protein is activated by peroxisome proliferator-activated receptor gamma through an intronic response element functionally conserved between humans and rodents. ', Journal of Biological Chemistry, vol. 277, no. 30, pp. 26821-30 . https://doi.org/10.1074/jbc.M111295200

Udgivelsesdato: 2002-Jul-26 The acyl-CoA-binding protein (ACBP) is a 10-kDa intracellular protein that specifically binds acyl-CoA esters with high affinity and is structurally and functionally conserved from yeast to mammals. In vitro studies indica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a17d1e1a4734972245b608b9f003149f
https://doi.org/10.1074/jbc.m111295200

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Expression of the Fatty Acid Receptor GPR120 in the Gut of Diet-Induced-Obese Rats and Its Role in GLP-1 Secretion

Autor: Niels Vrang, Philip J. Larsen, Shekar Siddalingaiah Chelur, Leif K. Larsen, Gitte Hansen, Sarah Juel Paulsen

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e88227 (2014)

Stimulation of the G protein coupled receptor GPR120 has been shown to have anti-inflammatory and insulin-sensitizing effects, to promote glucagon like peptide-1 (GLP-1) secretion, and to play a key role in sensing dietary fat and control energy bala

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04800cc6f2c6f4e4a651421cb533cee9
http://europepmc.org/articles/PMC3919739

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RIBOSOME SYNTHESIS IN TETRAHYMENA: A QUANTITATIVE ANALYSIS

Autor: Per Hove Andreasen, Leif K. Larsen, Karsten Kristiansen

Publikováno v: Larsen, L K, Andreasen, P H & Kristiansen, K 1999, ' Ribosome synthesis in T etrahymena : A quantitative analysis ', Cell Biology International, vol. 23, no. 11, pp. 729-738 . https://doi.org/10.1006/cbir.1999.0376

We have performed a detailed quantitative analysis of the transcription and accumulation of ribosomal RNA and ribosomal protein mRNA in the ciliated protozoan Tetrahymena thermophila during changes in growth conditions, and found that: (1) nutritiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102ce18de1ef20611a995a5daf2d249e
https://doi.org/10.1006/cbir.1999.0376

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CLONING AND CHARACTERIZATION OF THE GENE ENCODING THE HIGHLY EXPRESSED RIBOSOMAL PROTEIN L3 OF THE CILIATED PROTOZOANTETRAHYMENA THERMOPHILA . EVIDENCE FOR DIFFERENTIAL CODON USAGE IN HIGHLY EXPRESSED GENES

Autor: Henrik Nielsen, Lisbeth Palm, Karsten Kristiansen, Leif K. Larsen, Hanne Dreisig, Per Hove Andreasen, Jan Engberg

Publikováno v: Cell Biology International. 23:551-560

We have cloned and characterized the cDNA and the macronuclear genomic copy of the highly conserved ribosomal protein (r-protein) L3 of Tetrahymena thermophila. The r-protein L3 is encoded by a single copy gene interrupted by one intron. The organiza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1d8ce2016a9cd1a057a62cda4e2067
https://doi.org/10.1006/cbir.1999.0419

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Transcription in Vitro of Tetrahymena Class II and Class III Genes

Autor: Leif K. Larsen, Karsten Kristiansen

Publikováno v: Journal of Biological Chemistry. 270:7601-7608

A method for preparation of transcriptionally active nuclear extracts from the ciliated protozoan Tetrahymena thermophila is described. Cells were lysed in the presence of gum arabic, and nuclei were further purified in the presence of Ficoll 400. Hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b89a33e1592727204dade17c916ebf
https://doi.org/10.1074/jbc.270.13.7601

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Laser capture microdissection and quantitative-PCR analysis

Autor: Sarah J, Paulsen, Leif K, Larsen

Publikováno v: Methods in molecular biology (Clifton, N.J.). 789

Laser capture microdissection (LCM) provides an efficient and precise method for the sampling of single cells or subgroups of cells in heterogeneous tissues such as the brain. We have recently applied LCM coupled with microarray analysis for the exam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::afe2b156f318a5496bccc09a1a4368ae
https://pubmed.ncbi.nlm.nih.gov/21922404

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Laser Capture Microdissection and Quantitative-PCR Analysis

Autor: Sarah Juel Paulsen, Leif K. Larsen

Publikováno v: Methods in Molecular Biology ISBN: 9781617793097

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee669932278571c4b9757c538a9f01e8
https://doi.org/10.1007/978-1-61779-310-3_7

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